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Displaying results 8691 - 8700 of 10000 in total

Drug
Amedalin
go.drugbank.com/drugs/DB09188
Experimental
Amedalin is a selective norepinephrine reuptake inhibitor developed in the 1970s.
Synonyms: 3-methyl-3-(3-(methylamino)propyl)-1-phenyl-2-indolinone
Drug
Etoperidone
go.drugbank.com/drugs/DB09194
ApprovedWithdrawn
It is a phenylpiperazine-substituted triazole derivative with a composition that classifies it as an analog of tradozone and presents a similar pharmacological profile.
Categories: Heterocyclic Compounds, 1-Ring, Serotonin 5-HT2 Receptor Antagonists
Drug
Lobeglitazone
go.drugbank.com/drugs/DB09198
Investigational
Unlike [DB01132], which is a dual PPAR agonist at PPAR-alpha and PPAR-gamma, Lobeglitazone is a pure PPAR-alpha agonist.
Categories: Cytochrome P-450 Substrates, Cytochrome P-450 CYP1A2 Inhibitors
Drug
Ciglitazone
go.drugbank.com/drugs/DB09201
Experimental
Ciglitazone was never used as a medication, but it sparked interest in the effects of thiazolidinediones. … Ciglitazone is a potent and selective PPARγ ligand with an EC50 of 3.0 µM. It is also an anti-hyperglycemic agent in the ob/ob murine model in vivo.
Categories: Cytochrome P-450 Substrates, Cytochrome P-450 CYP2C8 Inhibitors
Drug
AS-8112
go.drugbank.com/drugs/DB09207
Experimental
AS-8112 is a synthetic compound that acts as a selective antagonist at the dopamine receptor subtypes D2 and D3, and the serotonin receptor 5-HT3.
Categories: Heterocyclic Compounds, 1-Ring
Drug
Droxicam
go.drugbank.com/drugs/DB09215
ApprovedWithdrawn
Droxicam is an oxicam non-steroidal anti-inflammatory drug and a prodrug of [DB00554].
Categories: Non COX-2 selective NSAIDS, Heterocyclic Compounds, 1-Ring
Drug
Tolfenamic acid
go.drugbank.com/drugs/DB09216
Approved
It is used in the UK as a treatment for migraine under the name of Clotam.[L1292] In the US, it presents a Status class I by the FDA. … Tolfenamic acid, with the formula N-(2-methyl-3-chlorphenyl)-anthranilic acid, is a nonsteroidal anti-inflammatory agent.
Categories: Cytochrome P-450 Substrates, Non COX-2 selective NSAIDSProducts: TOLFEDINE 4% W/V SOLUTION FOR INJECTION FOR DOGS AND CATS, Tolfine Solution for Injection 4.0% W/V
Drug
Blonanserin
go.drugbank.com/drugs/DB09223
Investigational
As a second-generation (atypical) antipsychotic, it is significantly more efficacious in the treatment of the negative symptoms of schizophrenia compared to first-generation (typical) antipsychotics.
Categories: Cytochrome P-450 Substrates, Heterocyclic Compounds, 1-Ring
Drug
Melperone
go.drugbank.com/drugs/DB09224
Investigational
Melperone has been used for a span of greater than 30 years in the European Union [L1316]. … Recently, it has been studied as a treatment of psychosis related to Parkinson's disease [L1316].
Categories: Cytochrome P-450 CYP2D6 Inhibitors, Cytochrome P-450 Enzyme InhibitorsProducts: MELPERON AL 25, MELPERON AL 100
Drug
Barnidipine
go.drugbank.com/drugs/DB09227
Investigational
after a 1-year and 2-year follow-up period in 91% of the patients who had an initial response to the drug [A7842]. … Compared to several other calcium antagonists which are racemates, the barnidipine compound consisting of a single enantiomer may offer a high degree of pharmacological selectivity [A31567].
Categories: Cytochrome P-450 Substrates, Heterocyclic Compounds, 1-Ring