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Delamanid
go.drugbank.com/drugs/DB11637ApprovedInvestigationalIt is used in the treatment of multidrug-resistant and extensively drug-resistant tuberculosis (TB) in a combination regimen. … Multidrug-resistant tuberculosis may also require more than 2 years of chemotherapy and second-line therapies with narrow therapeutic index [A31968].
Categories: Cytochrome P-450 Substrates, Cytochrome P-450 CYP3A SubstratesSynonyms: (2R)-2-methyl-6-nitro-2-((4-(4-(4-(trifluoromethoxy)phenoxy)piperidin-1-yl)phenoxy)methyl)-2,3-dihydroimidazo(2,1-B)(1,3)oxazole, (R)-2-methyl-6-nitro-2-{4-[4-(4-trifluoromethoxyphenoxy)piperidin-1-yl]phenoxymethyl}-2,3-dihydroimidazo[2,1-b]oxazoleLersivirine
go.drugbank.com/drugs/DB11649InvestigationalLersivirine has been used in trials studying the treatment of HIV-1.
Categories: Heterocyclic Compounds, 1-RingTabalumab
go.drugbank.com/drugs/DB11657InvestigationalTabalumab has been used in trials studying the treatment of Autoimmune Disease, Rheumatoid Arthritis, Kidney Failure, Chronic, Connective Tissue Disease, and Systemic Lupus Erythematosus, among others.
Categories: B-Cell Activating Factor, antagonists & inhibitorsPictilisib
go.drugbank.com/drugs/DB11663InvestigationalPictilisib has been used in trials studying the treatment of Solid Cancers, Breast Cancer, Advanced Solid Tumours, Metastatic Breast Cancer, and Non-Hodgkin's Lymphoma, Solid Cancers, among others.
Categories: Heterocyclic Compounds, 1-Ring, Heterocyclic Compounds, 2-RingBMS-690514
go.drugbank.com/drugs/DB11665InvestigationalBMS-690514 has been investigated for the treatment of Breast Cancer.
Categories: Heterocyclic Compounds, 1-RingRadgocitabine
go.drugbank.com/drugs/DB11667Investigational2'-cyano-2'-deoxy-1-(beta-D-arabinofuranosyl)cytosine has been used in trials studying the treatment of Advanced Colorectal Cancer.
Categories: Heterocyclic Compounds, 1-RingSynonyms: 2'-cyano-2'-deoxy-1-(beta-D-arabinofuranosyl)cytosineGalidesivir
go.drugbank.com/drugs/DB11676Investigational[L12039,L12084] Phase 1 clinical trials have begun to determine the safety of this drug in humans. … [L12042] Because of its activity against other coronaviruses, it may be studied as a potential therapy for COVID-19.
Categories: Heterocyclic Compounds, 1-Ring, Heterocyclic Compounds, 2-RingSynonyms: Immucillin A, Immucillin-ATriheptanoin
go.drugbank.com/drugs/DB11677ApprovedInvestigationalTriheptanoin is a source of heptanoate fatty acids, which can be metabolized without the enzymes of long chain fatty acid oxidation.
Pavinetant
go.drugbank.com/drugs/DB11692InvestigationalPavinetant has been used in trials studying the basic science and treatment of Safety and Schizophrenia.
Categories: Heterocyclic Compounds, 2-Ring, Receptors, Neurokinin-3, antagonists & inhibitorsVoclosporin
go.drugbank.com/drugs/DB11693ApprovedInvestigationalWithin 10 years of being diagnosed with SLE, 5-20% of those suffering from LN develop end-stage kidney disease, a fatal condition. … LN is a significant cause of renal failure, morbidity, and death in patients with SLE.
Categories: P-glycoprotein inhibitors, P-glycoprotein substrates