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Displaying results 871 - 880 of 6947 in total
  1. Target

    Interleukin-21 receptor

    go.drugbank.com/bio_entities/BE0010657
    TargetHumans

    This is a receptor for interleukin-21

    Polypeptides: Interleukin-21 receptorSynonyms: IL-21 receptor, Novel interleukin receptor
  2. Target

    Neuromedin-B receptor

    go.drugbank.com/bio_entities/BE0013104
    TargetHumans

    Receptor for neuromedin-B (PubMed:1655761). … Plays a role in CSF1-induced proliferation of osteoclast precursors by contributing to the positive regulation of the expression of the CSF1 receptor CSF1R (By similarity)

    Polypeptides: Neuromedin-B receptorSynonyms: Neuromedin-B-preferring bombesin receptor
  3. Target

    Interleukin-23 receptor

    go.drugbank.com/bio_entities/BE0015564
    TargetHumans

    Associates with IL12RB1 to form the interleukin-23 receptor.

    Polypeptides: Interleukin-23 receptorSynonyms: IL-23 receptor
  4. Target

    Discoidin domain receptor

    go.drugbank.com/bio_entities/BE0027487
    TargetHumans

    It functions as a cell surface receptor for fibrillar collagen and regulates cell differentiation, remodeling of the extracellular matrix, cell migration and cell proliferation. … Tyrosine kinase that functions as a cell surface receptor for fibrillar collagen and regulates cell attachment to the extracellular matrix, remodeling of the extracellular matrix, cell migration, differentiation

    Polypeptides: Discoidin domain-containing receptor 2, Epithelial discoidin domain-containing receptor 1Synonyms: Discoidin domain receptor 2, Discoidin receptor tyrosine kinase
  5. Target

    Interleukin-2 receptor

    go.drugbank.com/bio_entities/BE0027978
    TargetHumans

    Receptor for interleukin-2. This beta subunit is involved in receptor mediated endocytosis and transduces the mitogenic signals of IL2. … Receptor for interleukin-2. The receptor is involved in the regulation of immune tolerance by controlling regulatory T cells (TREGs) activity.

    Polypeptides: Cytokine receptor common subunit gamma, Interleukin-2 receptor subunit alphaSynonyms: IL-2 receptor subunit gamma, IL-2 receptor subunit alpha
  6. Drug

    Defibrotide

    go.drugbank.com/drugs/DB04932
    ApprovedInvestigational

    Defibrotide is the sodium salt of a mixture of single-stranded oligodeoxyribonucleotides derived from porcine mucosal DNA. It has been shown to have antithrombotic, anti-inflammatory and anti-ischemic properties (but without associated s...

  7. Target

    Cannabinoid receptor 1

    go.drugbank.com/bio_entities/BE0000061
    TargetHumans

    G protein-coupled receptor for endogenous cannabinoids (eCBs), including N-arachidonoylethanolamide (also called anandamide or AEA) and 2-arachidonoylglycerol (2-AG), as well as phytocannabinoids, such

    Polypeptides: Cannabinoid receptor 1Function: cannabinoid receptor activity
  8. Target

    Cannabinoid receptor 2

    go.drugbank.com/bio_entities/BE0000095
    TargetHumans

    Heterotrimeric G protein-coupled receptor for endocannabinoid 2-arachidonoylglycerol mediating inhibition of adenylate cyclase.

    Polypeptides: Cannabinoid receptor 2Function: cannabinoid receptor activity
  9. Target

    Substance-P receptor

    go.drugbank.com/bio_entities/BE0000384
    TargetHumans

    Substance P binding to its receptor triggers G protein-coupled receptor signaling via activation of phosphatidylinositol hydrolysis by phospholipase C. … The rank order of affinity of this receptor to tachykinins is: substance P > neurokinin A/substance K > neurokinin B/neuromedin-K (PubMed:1718267).

    Polypeptides: Substance-P receptorSynonyms: NK-1 receptor, Tachykinin receptor 1
  10. Target

    Dopamine receptor D4

    go.drugbank.com/bio_entities/BE0000389
    TargetHumans

    G protein-coupled receptor for dopamine, a catecholamine neurotransmitter hormone that functions as the brain's 'reward chemical', driving motivation, reinforcement learning and pleasure (PubMed:16423344 … Dopamine receptors can be classified in two categories: (1) DRD4 (together with DRD2 and DRD3) is a D2-type receptor and is coupled to G(i)/G(o) G proteins, mediating inhibition of adenylate cyclase activity

    Polypeptides: Dopamine receptor D4Synonyms: Dopamine D4 receptor, D(2C) dopamine receptor