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Displaying results 871 - 880 of 1804 in total
  1. Target

    Tyrosine-protein kinase transmembrane receptor ROR2

    go.drugbank.com/bio_entities/BE0010827
    TargetHumans

    May act as a receptor for wnt ligand WNT5A which may result in the inhibition of WNT3A-mediated signaling (PubMed:25029443) … Tyrosine-protein kinase receptor which may be involved in the early formation of the chondrocytes. It seems to be required for cartilage and growth plate development (By similarity).

    Polypeptides: Tyrosine-protein kinase transmembrane receptor ROR2Synonyms: Neurotrophic tyrosine kinase, receptor-related 2
  2. Target

    Killer cell immunoglobulin-like receptor 2DL2

    go.drugbank.com/bio_entities/BE0010848
    TargetHumans

    Receptor on natural killer (NK) cells for HLA-Cw1, 3, 7, and 8 allotypes. Inhibits the activity of NK cells thus preventing cell lysis

    Polypeptides: Killer cell immunoglobulin-like receptor 2DL2Synonyms: p58 NK receptor CL-43, p58 natural killer cell receptor clone CL-43
  3. Target

    Killer cell immunoglobulin-like receptor 3DL2

    go.drugbank.com/bio_entities/BE0010849
    TargetHumans

    Receptor on natural killer (NK) cells and T cells for MHC class I molecules (PubMed:24018270, PubMed:28636952). … Acts as a receptor on astrocytes for HLA-F. Through interaction with HLA-F, may protect motor neurons from astrocyte-induced toxicity (PubMed:26928464)

    Polypeptides: Killer cell immunoglobulin-like receptor 3DL2Synonyms: p70 NK receptor CL-5, p70 natural killer cell receptor clone CL-5
  4. Target

    Interleukin-22 receptor subunit alpha-1

    go.drugbank.com/bio_entities/BE0016650
    TargetHumans

    Component of the receptor for IL20, IL22 and IL24. Component of IL22 receptor formed by IL22RA1 and IL10RB enabling IL22 signaling via JAK/STAT pathways. … Component of one of the receptor for IL20 and IL24 formed by IL22RA1 and IL20RB also signaling through STATs activation.

    Polypeptides: Interleukin-22 receptor subunit alpha-1Synonyms: IL-22 receptor subunit alpha-1, Cytokine receptor class-II member 9
  5. Target

    Taste receptor type 2 member 3

    go.drugbank.com/bio_entities/BE0023234
    TargetHumans

    Gustducin-coupled receptor implicated in the perception of bitter compounds in the oral cavity and the gastrointestinal tract. Signals through PLCB2 and the calcium-regulated cation channel TRPM5

    Polypeptides: Taste receptor type 2 member 3Function: bitter taste receptor activity
  6. Target

    T cell receptor beta variable 13

    go.drugbank.com/bio_entities/BE0023663
    TargetHumans

    V region of the variable domain of T cell receptor (TR) beta chain that participates in the antigen recognition (PubMed:24600447).

    Polypeptides: T cell receptor beta variable 13
  7. Target

    T cell receptor delta variable 2

    go.drugbank.com/bio_entities/BE0023749
    TargetHumans

    V region of the variable domain of T cell receptor (TR) delta chain that participates in the antigen recognition (PubMed:24600447).

    Polypeptides: T cell receptor delta variable 2
  8. Drug

    Elasomeran

    go.drugbank.com/drugs/DB15654
    ApprovedInvestigational

    [L28026] A phase I, open-label, dose-ranging clinical trial (NCT04283461) was initiated in March 2020 in which 45 subjects received two intramuscular doses (on days 1 and 29).

  9. Target

    G protein-coupled receptor kinase 3

    go.drugbank.com/bio_entities/BE0000018
    TargetHumans

    Such receptor phosphorylation initiates beta-arrestin-mediated receptor internalization, and signaling events leading to their desensitization (PubMed:21799898, PubMed:33859231). … Also phosphorylates ligand-bound C3a and C5a anaphylatoxin receptors (C3AR1 and C5AR1, respectively), leading to receptor desensitization (PubMed:21799898).

    Polypeptides: G protein-coupled receptor kinase 3Synonyms: Beta-adrenergic receptor kinase 2
  10. Target

    Vascular endothelial growth factor receptor 1

    go.drugbank.com/bio_entities/BE0000029
    TargetHumans

    Tyrosine-protein kinase that acts as a cell-surface receptor for VEGFA, VEGFB and PGF, and plays an essential role in the development of embryonic vasculature, the regulation of angiogenesis, cell survival

    Polypeptides: Vascular endothelial growth factor receptor 1Synonyms: Tyrosine-protein kinase receptor FLT, Vascular permeability factor receptor