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Thienylfentanyl
go.drugbank.com/drugs/DB09180ExperimentalIllicitThienylfentanyl has a similar synthesis pathway to fentanyl except 2-(2-bromoethyl)thiophene is substituted for phenethyl bromide. … Thienylfentanyl is a fentanyl analog analgesic that was sold on the black market in the 1980s until the Federal Analog Act scheduled drugs based on structural similarity rather than scheduling drugs individually
Benzylfentanyl
go.drugbank.com/drugs/DB09182ExperimentalIllicitBenzylfentanyl (R-4129) is a fentanyl analog opioid that was on the list of Schedule I drugs in America in 1985 due to its structural similarity to fentanyl. … Benzylfentanyl has a Ki of 213nM at the mu opioid receptor, binding around 200x less strongly than fentanyl itself.
Categories: Heterocyclic Compounds, 1-RingNisoxetine
go.drugbank.com/drugs/DB09186ExperimentalNisoxetine is a selective norepinephrine reuptake inhibitor (SNRI) developed in the 1970s. … It was originally investigated as an antidepressant but has no current clinical applications aside from being a research standard SNRI.
Talopram
go.drugbank.com/drugs/DB09190ExperimentalTalopram is a selective norepinephrine reuptake inhibitor (SNRI) that is structurally similar to citalopram and melitracen. It was researched in the 1960s and 1970s but never marketed.
Categories: Heterocyclic Compounds, 2-RingTalsupram
go.drugbank.com/drugs/DB09191ExperimentalTalsupram presents a similar structure to [citalopram]. … Talsupram is a selective norepinephrine reuptake inhibitor (NRI). It was under research for the treatment of depression in 1960 and 1970 but it was never marketed.
Categories: Heterocyclic Compounds, 1-RingMepiprazole
go.drugbank.com/drugs/DB09197ExperimentalMepiprazole is a minor tranquilizer with a phenylpiperazine structure. It is a pyrazolyl-alkyl-piperazine derivative. … Mepiprazole mediates a weak inhibitory action on the uptake of 5-HT on hypothalamic neurons [A7816]. Mepiprazole is marketed in Spain for the treatment of anxiety neuroses.
Categories: Heterocyclic Compounds, 1-RingRivoglitazone
go.drugbank.com/drugs/DB09200InvestigationalRivoglitazone (INN) is a thiazolidinedione undergoing research for use in the treatment of type 2 diabetes. It is being developed by Daiichi Sankyo Co.
Categories: Cytochrome P-450 Substrates, Cytochrome P-450 CYP2C8 InhibitorsLimaprost
go.drugbank.com/drugs/DB09211InvestigationalThe drug has been sold under the trade name of Opalmon® Tablets by Ono and Prorenal® Tablets by DSP. … Limaprost (as Limaprost alfadex; CAS number 88852-12-4) is an oral prostaglandin E1 analog.
Categories: Prostaglandins EProducts: OPALMON TABLETS 5 ugDexibuprofen
go.drugbank.com/drugs/DB09213ApprovedWithdrawnDexibuprofen, S(+)-ibuprofen, is a non-steroidal anti-inflammatory drug (NSAID). It is a pharmacologically effective enantiomer of racemic ibuprofen that differs in physicochemical properties. … It is proposed to be more pharmacologically active and tolerable with a better safety profile than ibuprofen due to higher concentration of active S enantiomer.
Synonyms: (S)-α-methyl-4-(2-methylpropyl)benzeneacetic acid, (+)-(S)-p-isobutylhydratropic acidMixtures: TAFLAX® GRIP, TAFLAX®FORTE TABLETAS RECUBIERTASFirocoxib
go.drugbank.com/drugs/DB09217ExperimentalVet approvedFirocoxib is a cycooxygenase-2 (COX-2) selective non-steroidal anti-inflammatory drug. It currently approved for veterinary use in dogs and horses under the brand names Equioxx and Previcox. … Firocoxib was the first COX-2 inhibitor approved by the U.S. Food and Drug Administration for horses. Firocoxib is not intended or approved for use in human medicine.
Categories: Heterocyclic Compounds, 1-Ring, Selective Cyclooxygenase 2 Inhibitors (NSAIDs)