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go.drugbank.com/drugs/DB00092ApprovedWithdrawnImmunosuppressive dimeric fusion protein that consists of the extracellular CD2-binding portion of the human leukocyte function antigen-3 (LFA-3) linked to the Fc (hinge, CH2 and CH3 domains) portion of
Categories: CD2-directed LFA-3/Fc Fusion ProteinCasimersen
go.drugbank.com/drugs/DB14984ApprovedInvestigationalDuchenne muscular dystrophy (DMD) is an X-linked recessive allelic disorder characterized by a lack of functional dystrophin protein, which leads to progressive impairment of ambulatory, pulmonary, and … Casimersen was granted accelerated FDA approval on February 25, 2021, based on data showing an increase in dystrophin levels in skeletal muscle of patients treated with casimersen; this approval is contingent
Categories: Heterocyclic Compounds, 1-Ring, Cytochrome P-450 CYP2C19 InhibitorsMilnacipran
go.drugbank.com/drugs/DB04896ApprovedInvestigationalfor noradrenaline reuptake inhibition - which is potentially a point of interest given the plausible proposal that noradrenaline plays an important role in the mitigation of pain signals in the descending … Moreover, recent research has shown that the levorotatory enantiomer of milnacipran, levomilnacipran, may have the capacity to inhibit the activity of beta-site amyloid precursor protein cleaving enzyme
Categories: Cytochrome P-450 Substrates, Cytochrome P-450 CYP3A InhibitorsChloroprocaine
go.drugbank.com/drugs/DB01161ApprovedInvestigational[A252952] Chloroprocaine can be given as an injection, and is available in formulations with and without methylparaben as a preservative. … Both can be given as intrathecal injections for peripheral and central nerve block, but only the preservative-free formulation can be used for lumbar and caudal epidural blocks.
Synonyms: 2-(Diethylamino)ethyl 4-amino-2-chlorobenzoate, 4-amino-2-chlorobenzoic acid 2-(diethylamino)ethyl esterProducts: Nesacaine Ce 2% Inj 20mg/ml, Nesacaine Ce 3% Inj 30mg/mlEmtricitabine
go.drugbank.com/drugs/DB00879ApprovedInvestigational[L9019] Emtricitabine was granted FDA approval on 2 July 2003.[L9019] … Emtricitabine is a nucleoside reverse transcriptase inhibitor (NRTI) indicated for the treatment of HIV infection in adults[L9019] or combined with [tenofovir alafenamide] for the prevention of HIV-1 infection
Synonyms: (−)-β-2',3'-dideoxy-5-fluoro-3'-thiacytidine, (−)-cis-4-amino-5-fluoro-1-(2-hydroxymethyl-1,3-oxathiolan-5-yl)-(1H)-pyrimidin-2-oneMixtures: EMTRICITABINA E TENOFOVIR DISOPROXIL DR. REDDY'S, EMTRICITABINA E TENOFOVIR DISOPROXIL DR. REDDY'SCetyl alcohol
go.drugbank.com/drugs/DB09494ApprovedCetyl alcohol, also known as 1-hexadecanol or n-hexadecyl alcohol, is a 16-C fatty alcohol with the chemical formula CH3(CH2)15OH. It can be produced from the reduction of palmitic acid. … It may be contained in cosmetic and personal care products such as shampoos, creams and lotions.
Synonyms: hexadecan-1-olLinvoseltamab
go.drugbank.com/drugs/DB17447ApprovedInvestigational[L53348][L53353] Linvoseltamab is indicated for adult patients with RRMM who have previously received at least three classes of therapy: a proteasome inhibitor, an immunomodulatory agent, and an anti-CD38 … By binding to both targets simultaneously, linvoseltamab redirects T cells toward myeloma cells, forming an immunological synapse that activates T-cell–mediated cytotoxicity.
Synonyms: human IgG4-based anti-CD3 x anti-BCMA bispecific monoclonal antibody that binds to CD3 and BCMACategories: Bispecific B Cell Maturation Antigen-directed CD3 T Cell EngagerGoserelin
go.drugbank.com/drugs/DB00014ApprovedInvestigationalGoserelin is a synthetic hormone. In men, it stops the production of the hormone testosterone, which may stimulate the growth of cancer cells. … In women, goserelin decreases the production of the hormone estradiol (which may stimulate the growth of cancer cells) to levels similar to a postmenopausal state.
Products: ZOLADEX ® 3.6MG, ZOLADEX ® LA 10.8 MGNorgestimate
go.drugbank.com/drugs/DB00957ApprovedInvestigational[A191068] It is commonly formulated with [ethinylestradiol] as a combined oral contraceptive that can also be used to treat moderate acne vulgaris. … [A191068] It was developed by Ortho Pharmaceutical Corporation as part of an effort to develop new hormonal contraceptives with reduced adverse effects.
Synonyms: d-13β-Ethyl-17α-ethynyl-17β-acetoxygon-4-en-3-one oxime, (17α)-17-(Acetyloxy)-13-ethyl-18,19-dinorpregn-4-en-20-yn-3-one 3-oximeCategories: P-glycoprotein inhibitors, Cytochrome P-450 SubstratesPhenylephrine
go.drugbank.com/drugs/DB00388ApprovedInvestigationalPhenylephrine is an alpha-1 adrenergic receptor agonist used to treat hypotension,[L9416,L9410] dilate the pupil,[L9413] and induce local vasoconstriction.
Synonyms: l-(3-Hydroxyphenyl)-N-methylethanolamine, (−)-m-hydroxy-α-(methylaminomethyl)benzyl alcoholMixtures: Pyril Mal Phenyl HCl Dex HBr, Brom Mal Phenyl HCl Dex HBr