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Prucalopride
go.drugbank.com/drugs/DB06480ApprovedInvestigationalPrucalopride is a dihydrobenzofurancarboxamide derivative from the benzofurane family that selectively stimulates 5-HT4 receptors and thus, it presents enterokinetic properties. … [A37348] The high selectivity of prucalopride allowed further development as it prevented the cardiac adverse reactions observed due to non-target effects of precedent therapies.
Categories: Cytochrome P-450 Substrates, P-glycoprotein substratesProducts: RESOLOR ® TABLETAS RECUBIERTAS DE 2 MG, RESOLOR ® TABLETAS RECUBIERTAS DE 1 MGTacrolimus
go.drugbank.com/drugs/DB00864ApprovedInvestigationalIt was discovered in 1984 from the fermentation broth of a Japanese soil sample that contained the bacteria Streptomyces tsukubaensis. Tacrolimus is chemically known as a macrolide. … It reduces peptidyl-prolyl isomerase activity by binding to the immunophilin FKBP-12 (FK506 binding protein) creating a new complex.
Mixtures: Hyaluronic Acid Sodium Salt 1% / Niacinamide 4% / Tacrolimus 0.1%, Niacinamide 4% / Tacrolimus 0.1%Categories: P-glycoprotein substrates with a Narrow Therapeutic Index, Cytochrome P-450 CYP3A4 Substrates with a Narrow Therapeutic IndexKetorolac
go.drugbank.com/drugs/DB00465ApprovedInvestigational[L6520] Impressively, ketorolac has a similar efficacy to standard doses of morphine and meperidine making it a useful opioid sparing agent.[L6511] … Ketorolac is a Non-steroidal anti-inflammatory drug (NSAID) and is commercially available as an oral tablet, injectable, nasal spray and as an ophthalmic solution.
Mixtures: Ketorocaine L Kit, ONEMER DTCategories: Cytochrome P-450 Substrates, Non COX-2 selective NSAIDSSodium iodide
go.drugbank.com/drugs/DB11119ApprovedInvestigationalSodium iodide is a source of iodine and can be administered as a supplement for total parenteral nutrition [L2065] but is more commonly used in veterinary medicine. … Sodium iodide is a water-soluble ionic compound with a crystal lattice.
Mixtures: De La Cruz Tincture of Iodine, Micro+ Te PediatricProducts: YODURO DE SODIO NA131I SOLUCIÓNINYECTABLE, Micro ICitric acid
go.drugbank.com/drugs/DB04272ApprovedInvestigationalNutraceuticalVet approvedA key intermediate in metabolism. It is an acid compound found in citrus fruits. The salts of citric acid (citrates) can be used as anticoagulants due to their calcium-chelating ability. … Citric acid is one of the active ingredients in Phexxi, a non-hormonal contraceptive agent that was approved by the FDA on May 2020.
Synonyms: 3-carboxy-3-hydroxypentane-1,5-dioic acid, 2-Hydroxytricarballylic acidMixtures: Dr. Juans Santo Remedio PARA LA ACIDEZ, A-C-D SolutionThiosulfuric acid
go.drugbank.com/drugs/DB09499ApprovedInvestigationalSodium thiosulfate is part of the World Health Organization’s list of essential medicines, and it has a variety of industrial uses, including food preservative, water de-chlorinator and paper pulp bleaching … [L43337] When administered 6 hours after cisplatin chemotherapy, Sodium thiosulfate leads to a lower incidence of cisplatin-induced hearing loss among children without affecting its effectiveness.
Synonyms: Sulfurothioic S-acidMixtures: Sodium Polysulthionate, 5-mthf, Sodium polysulthionate, 5-methyltetrahydrofolateSodium carbonate
go.drugbank.com/drugs/DB09460ApprovedWithdrawnAs a strong base, sodium hydroxide neutralizes gastric acid thereby acting as an antacid.
Synonyms: Soda ash, Soda-ashMixtures: GAVISCON® TABLETAS MASTICABLES SABOR A MENTA, Sel De PerouFlurbiprofen
go.drugbank.com/drugs/DB00712ApprovedInvestigationalFlurbiprofen, a propionic acid derivative, is a nonsteroidal anti-inflammatory agent (NSAIA) with antipyretic and analgesic activity. … Flurbiprofen may also be used topically prior to ocular surgery to prevent or reduce intraoperative miosis.
Mixtures: MAJEZIK DUO %5 + %0.25 TOPIKAL JEL, 50 G, MERDEX DUO %5 + %0.25 TOPIKAL JEL, 30 GCategories: Cytochrome P-450 Substrates, Non COX-2 selective NSAIDSPentoxifylline
go.drugbank.com/drugs/DB00806ApprovedInvestigational[A226410, A226415, A226455] More recently, PTX has been suggested as a possible treatment for COVID-19-induced pulmonary complications due to its ability to regulate the production of inflammatory cytokines … Pentoxifylline (PTX) is a synthetic dimethylxanthine derivative that modulates the rheological properties of blood and also has both anti-oxidant and anti-inflammatory properties.
Mixtures: Betamethasone Dipropionate 0.05% / Minoxidil 5% / Niacinamide 2% / Pentoxifylline 0.5%Categories: Compounds used in a research, industrial, or household setting, Cytochrome P-450 SubstratesTimolol
go.drugbank.com/drugs/DB00373ApprovedInvestigational[L6724] It is also used in tablet form as a drug to treat hypertension.[L6727] Timolol was first approved by the FDA in 1978. … Timolol is a nonselective beta-adrenergic antagonist given in an eye drop solution to reduce intraocular pressure, or pressure in the eyes.
Mixtures: KRYTANTEK OFTENO® LIBRE DE CONSERVADORES, KRYTANTEK OFTENO® LIBRE DE CONSERVADORESCategories: P-glycoprotein substrates, Cytochrome P-450 Substrates