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Milnacipran SNRI - Norepinephrine reuptake Inhibition Action Pathway
smpdb.ca/view/SMP0126429Drug actionMilnacipran is a serotonin and norepinephrine reuptake inhibitor (SNRI). It is used in the management of fibromyalgia, major depressive disorder, generalized anxiety disorder, chronic musculoskeletal pain and diabetic peripheral neuropat...
Drugs: Pyridoxal phosphate · Ascorbic acid · Tyrosine · Norepinephrine · Dopamine · Levodopa +4 moreEnzymes: Aromatic-L-amino-acid decarboxylaseLevomilnacipran SNRI - Norepinephrine reuptake Inhibition Action Pathway
smpdb.ca/view/SMP0126430Drug actionLevomilnacipran (the more active 1S, 2R - enantiomer of milnacipran) is a serotonin and norepinephrine reuptake inhibitor (SNRI). It is used in the management of major depressive disorder, generalized anxiety disorder, chronic musculoske...
Drugs: Pyridoxal phosphate · Ascorbic acid · Tyrosine · Norepinephrine · Dopamine · Levodopa +4 moreEnzymes: Aromatic-L-amino-acid decarboxylaseCocaine Norepinephrine Reuptake Inhibitor Action Pathway
smpdb.ca/view/SMP0126544Drug actionCocaine is a local anesthesia and vasoconstrictor that is clinically used during diagnostic proceedures or during surgery in or through the nasal cavity. It comes in drugs called Goprelto and Numbrino which comes as a nasal spray. In the...
Enzymes: Aromatic-L-amino-acid decarboxylaseMethamphetamine Norepinephrine Reuptake Inhibitor Action Pathway
smpdb.ca/view/SMP0126618Drug actionMethamphetamine (metamfetamine) is a psychostimulant and sympathomimetic drug. It is mainly taken recreationally but can be taken for ADHD and exogenous obesity in the form of a drug called Desoxyn. Methamphetamine induces effects of eup...
Drugs: Pyridoxal phosphate · Ascorbic acid · Tyrosine · Norepinephrine · Dopamine · Levodopa +4 moreEnzymes: Aromatic-L-amino-acid decarboxylaseDesvenlafaxine SNRI - Norepinephrine reuptake Inhibition Action Pathway
smpdb.ca/view/SMP0126425Drug actionThe exact mechanism of action of venlafaxine in the treatment of various psychiatric conditions has not been fully elucidated; however, it is understood that venlafaxine and its active metabolite O-desmethylvenlafaxine (ODV) commonly cal...
Drugs: Pyridoxal phosphate · Ascorbic acid · Tyrosine · Venlafaxine · Norepinephrine · Dopamine +6 moreEnzymes: Aromatic-L-amino-acid decarboxylaseMaprotiline Action Pathway
smpdb.ca/view/SMP0126344Drug actionMaprotiline is an antidepressant used to treat depressive illness, major depressive disorder, bipolar disorder, and anxiety associated with depression. This tetracyclic molecule strongly inhibits neuronal norepinephrine reuptake in the b...
Drugs: Pyridoxal phosphate · Ascorbic acid · Tyrosine · Sapropterin · Norepinephrine · Maprotiline +5 moreEnzymes: Aromatic-L-amino-acid decarboxylaseAtomoxetine Action Pathway (New)
smpdb.ca/view/SMP0126353Drug actionAtomoxetine, also known as Strattera, is a selective norepinephrine reuptake inhibitor (SNRI). It is used in the management of attention deficit hyperactivity disorder (ADHD). Although the underlying pathophysiology that causes ADHD rema...
Drugs: Pyridoxal phosphate · Ascorbic acid · Tyrosine · Atomoxetine · Sapropterin · Norepinephrine +5 moreEnzymes: Aromatic-L-amino-acid decarboxylaseTrimipramine Action Pathway
smpdb.ca/view/SMP0126348Drug actionTrimipramine is a tricyclic antidepressant (TCA) used to treat depression accompanied or not by anxiety and agitation or sleep disturbance. It is very similar to imipramine but it has more antihistaminic and sedative properties. Trimipra...
Drugs: Pyridoxal phosphate · Ascorbic acid · Tyrosine · Tryptophan · Sapropterin · Norepinephrine +7 moreEnzymes: Aromatic-L-amino-acid decarboxylaseImipramine Action Pathway (New)
smpdb.ca/view/SMP0126359Drug actionImipramine is a dibenzazepine-derivative tricyclic antidepressant. It is indicated for the treatment of depression and to reduce childhood enuresis. This drug can also be used off-label to manage panic disorders with or without agoraphob...
Drugs: Pyridoxal phosphate · Ascorbic acid · Tyrosine · Tryptophan · Sapropterin · Norepinephrine +7 moreEnzymes: Aromatic-L-amino-acid decarboxylaseMethyldopa Action Pathway
smpdb.ca/view/SMP0125087Drug actionMethyldopa is a centrally-acting alpha-2 adrenergic agonist used to manage hypertension alone or in combination with hydrochlorothiazide, and to treat hypertensive crises. Alpha-adrenergic receptors are essential for the regulation of bl...
Drugs: Pyridoxal phosphate · Ascorbic acid · Tyrosine · Sapropterin · Norepinephrine · Dopamine +5 moreEnzymes: Aromatic-L-amino-acid decarboxylase