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Displaying results 81 - 90 of 298 in total
  1. Drug

    Paltusotine

    go.drugbank.com/drugs/DB16277
    ApprovedInvestigational

    the biological actions of endogenous somatostatin, which activates the somatostatin 2 receptor (SST2) to block the secretion of growth hormone (GH) and decreases the production of growth-promoting insulin-like

  2. Drug

    NN344

    go.drugbank.com/drugs/DB05115
    Experimental

    NN344 is a neutral, soluble long-acting human insulin analogue with 24 hour coverage by once daily injection. NN344 has a very flat and predictable action profile. … The product is intended for basal insulin treatment of diabetes mellitus.

    Categories: Insulin, Insulin, Long-Acting
  3. Drug

    Pioglitazone

    go.drugbank.com/drugs/DB01132
    ApprovedInvestigational

    [L11416] The thiazolidinedione class of medications, which also includes [rosiglitazone] and [troglitazone], exerts its pharmacological effect primarily by promoting insulin sensitivity and the improved

  4. Target

    CCN family member 3

    go.drugbank.com/bio_entities/BE0001147
    TargetHumans

    Impairs pancreatic beta-cell function, inhibits beta-cell proliferation and insulin secretion (By similarity).

    Synonyms: Insulin-like growth factor-binding protein 9
  5. Target

    CCN family member 2

    go.drugbank.com/bio_entities/BE0013178
    TargetHumans

    Major connective tissue mitoattractant secreted by vascular endothelial cells. Promotes proliferation and differentiation of chondrocytes. Is involved in the stimulation of osteoblast differentiation and has a critical role in osteogenes...

    Synonyms: Insulin-like growth factor-binding protein 8
  6. Indication

    Diabetes Mellitus

    go.drugbank.com/conditions/DBCOND0027886
    Drugs: Ammonium chloride · Borneol · Insulin aspart · Insulin degludec · Insulin glargine · Insulin glulisine +4 more
  7. Drug

    Somatrem

    go.drugbank.com/drugs/DB09098
    ApprovedWithdrawn

    Despite the ability of almost all contemporary recombinant growth hormones to cause definite and demonstrable increases in growth rate in patients who are administered the drug, the use of these agents continues to be mired in persistent...

    Categories: Sex Hormones and Insulins
  8. Drug

    Cixutumumab

    go.drugbank.com/drugs/DB12250
    Investigational

    Cixutumumab is a highly specific recombinant human monoclonal antibody with high affinity for the insulin-like growth factor-I receptor (IGF-IR). IGF-IR is overexpressed in a variety of tumour types.

  9. Drug

    Sitagliptin

    go.drugbank.com/drugs/DB01261
    ApprovedInvestigational

    The effect of this medication leads to glucose dependent increases in insulin and decreases in glucagon to improve control of blood sugar[FDA label,A2255].

  10. Target

    Mitogen-activated protein kinase 3

    go.drugbank.com/bio_entities/BE0001062
    TargetHumans

    Serine/threonine kinase which acts as an essential component of the MAP kinase signal transduction pathway (PubMed:34497368). MAPK1/ERK2 and MAPK3/ERK1 are the 2 MAPKs which play an important role in the MAPK/ERK cascade. They participat...

    Synonyms: Insulin-stimulated MAP2 kinase