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Anastrozole
go.drugbank.com/drugs/DB01217ApprovedInvestigationalas compared to earlier estrogen receptor modulators such as [tamoxifen]. … [L8863] Anastrozole is also related to [exemestane], a steroidal AI, but its non-steroidal nature provides stark advantages including a lack of steroid-associated adverse effects such as weight gain and
Categories: P-glycoprotein substrates, Cytochrome P-450 SubstratesSynonyms: α,α,α',α'-Tetramethyl-5-(1H-1,2,4-triazol-1-ylmethyl)-m-benzenediacetonitrileDantrolene
go.drugbank.com/drugs/DB01219ApprovedInvestigationalChemically, dantrolene is a hydantoin derivative, but does not exhibit antiepileptic activity like other hydantoin derivates such as phenytoin.
Categories: Heterocyclic Compounds, 1-RingSynonyms: 1-((5-(p-nitrophenyl)furfurylidene)amino)hydantoinKetamine
go.drugbank.com/drugs/DB01221ApprovedInvestigationalVet approvedKetamine is an NMDA receptor antagonist with a potent anesthetic effect.[A31869] It was developed in 1963 as a replacement for phencyclidine (PCP) by Calvin Stevens at Parke Davis Laboratories. … It was FDA approved in 1970, and from there, it has been used as an anesthetic for children or patients undergoing minor surgeries but mainly for veterinary purposes.[L1332]
Categories: Cytochrome P-450 Substrates, N-Methylaspartate, agonistsSynonyms: 2-(2-Chloro-phenyl)-2-methylamino-cyclohexanone, 2-(methylamino)-2-(2-chlorophenyl)cyclohexanoneLevacetylmethadol
go.drugbank.com/drugs/DB01227ApprovedWithdrawnLevacetylmethadol was withdrawn from use in the European Union due to its high risk of QT interval prolongation. The production of levacetylmethadol in the US has ceased as well.[L44052,T862] … Levacetylmethadol is a narcotic analgesic with a long onset and duration of action. It is used mainly in the treatment of narcotic dependence.
Categories: Cytochrome P-450 CYP3A4 Substrates with a Narrow Therapeutic Index, Cytochrome P-450 CYP3A7 Substrates with a Narrow Therapeutic IndexSynonyms: (1S,4S)-4-(dimethylamino)-1-ethyl-2,2-diphenylpentyl acetate, 1-alpha-AcetylmethadolEncainide
go.drugbank.com/drugs/DB01228ApprovedWithdrawnEncainide hydrochloride, formerly marketed as Enkaid capsules, was associated with increased death rates in patients who had asymptomatic heart rhythm abnormalities after a recent heart attack. … The manufacturer of Enkaid capsules voluntarily withdrew the product from the US market on December 16, 1991.
Categories: Antiarrhythmics, Class I, Cytochrome P-450 SubstratesSynonyms: (±)-2'-[2-(1-methyl-2-piperidyl)ethyl]-p-anisanilide, (±)-4-methoxy-N-(2-(2-(1-methyl-2-piperidinyl)ethyl)phenyl)benzamideSaquinavir
go.drugbank.com/drugs/DB01232ApprovedInvestigationalSaquinavir is an HIV-1 protease inhibitor used in combination with [ritonavir] and other antiretrovirals for the treatment of human immunodeficiency virus-1 (HIV-1) infection. … In 1995 it became the first protease inhibitor approved by the FDA, followed shortly by ritonavir in 1996, and remains in clinical use today due to a relatively benign adverse effect profile as compared
Categories: P-glycoprotein inducers, P-glycoprotein inhibitorsProducts: BIOQUINAVIR ® CAPSULAS 200MGChlorprothixene
go.drugbank.com/drugs/DB01239ApprovedInvestigationalWithdrawnChlorprothixene is a typical antipsychotic drug of the thioxanthene (tricyclic) class. … Chlorprothixene exerts strong blocking effects by blocking the 5-HT2 D1, D2, D3, histamine H1, muscarinic and alpha1 adrenergic receptors.
Categories: P-glycoprotein inhibitors, Heterocyclic Compounds, 3-RingGemfibrozil
go.drugbank.com/drugs/DB01241ApprovedInvestigationalGemfibrozil is a fibric acid agent, similar to [clofibrate], used to treat Type IIb, IV, and V hyperlipidemias. … [A185777,L8525] Gemfibrozil is not a first line treatment and is prescribed to patients who have not responded adequately to weight loss, diet, exercise, and other medications.
Categories: Cytochrome P-450 Substrates, Cytochrome P-450 CYP1A2 InhibitorsSynonyms: 2,2-Dimethyl-5-(2,5-xylyloxy)valeriansäure, 2,2-Dimethyl-5-(2,5-xylyloxy)valeric acidBepridil
go.drugbank.com/drugs/DB01244ApprovedWithdrawnIt has antihypertensive and selective anti-arrhythmia activities and acts as a calmodulin antagonist. … It is no longer marketed in the United States, as it has been implicated in causing ventricular arrhythmias (ie. Torsade de pointes).
Categories: P-glycoprotein inhibitors, Cytochrome P-450 SubstratesSynonyms: 1-(2-(N-BENZYLANILINO)-1-(ISOBUTOXYMETHYL)ETHYL)-PYRROLIDINE, 1-PYRROLIDENEETHANAMINE, .BETA.-((2-METHYLPROPOXY)METHYL)-N-PHENYL-N-(PHENYLMETHYL)-Alimemazine
go.drugbank.com/drugs/DB01246ApprovedVet approvedWithdrawnA phenothiazine derivative that is used as an antipruritic.
Categories: Heterocyclic Compounds, 3-Ring