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Displaying results 9111 - 9120 of 10000 in total
  1. Drug

    Parecoxib

    go.drugbank.com/drugs/DB08439
    ApprovedInvestigational

    A letter of non-approval for parecoxib was issued by the FDA in 2005. … Parecoxib is a COX2 selective inhibitor in the same category as celecoxib (Celebrex) and rofecoxib (Vioxx).

    Synonyms: N-((p-(5-methyl-3-phenyl-4-isoxazolyl)phenyl)sulfonyl)propionamide
  2. Drug

    Cabozantinib

    go.drugbank.com/drugs/DB08875
    ApprovedInvestigational

    Cabozantinib was first approved in 2012 and is a non-specific tyrosine kinase inhibitor. … [L15123] In 2016, a capsule formulation (Cabometyx) was approved for the treatment of advanced renal cell carcinoma, and this same formulation gained additional approval in both the US and Canada in 2019

    Categories: Cytochrome P-450 CYP2C9 Substrates with a Narrow Therapeutic Index, Cytochrome P-450 CYP3A4 Substrates with a Narrow Therapeutic Index
  3. Drug

    Hydroxydione

    go.drugbank.com/drugs/DB08956
    ApprovedWithdrawn

    Hydroxydione (Viadril) is a neuroactive steroid used as a general anesthetic.

  4. Drug

    Hexamethonium

    go.drugbank.com/drugs/DB08960
    Experimental

    used a research tool. … A nicotinic cholinergic antagonist often referred to as the prototypical ganglionic blocker. It is poorly absorbed from the gastrointestinal tract and does not cross the blood-brain barrier.

    Synonyms: N,N,N,N',N',N'-hexamethylhexane-1,6-diaminium
  5. Drug

    Cloperastine

    go.drugbank.com/drugs/DB09002
    Investigational

    Cloperastine is a cough suppressant that acts on the central nervous system.

  6. Drug

    Cefaloridine

    go.drugbank.com/drugs/DB09008
    ApprovedWithdrawn

    Cephaloridine or cefaloridine is a first generation semisynthetic cephalosporin. It is derived from cephalosporin C and is a zwitterion at physiological pH.

  7. Drug

    Articaine

    go.drugbank.com/drugs/DB09009
    ApprovedInvestigational

    Articaine is a dental local anesthetic. Articaine is widely used around the world and is the most popular local anesthetic in many European countries.

    Mixtures: Septanest N, Posicaine N
  8. Drug

    Suvorexant

    go.drugbank.com/drugs/DB09034
    ApprovedInvestigational

    Suvorexant is a selective dual antagonist of orexin receptors OX1R and OX2R that promotes sleep by reducing wakefulness and arousal. It has been approved for the treatment of insomnia.

  9. Drug

    Cefminox

    go.drugbank.com/drugs/DB09062
    Experimental

    Cefminox (INN) is a second generation cephalosporin antibiotic. It is approved for use in Japan.

  10. Drug

    Lenvatinib

    go.drugbank.com/drugs/DB09078
    ApprovedInvestigational

    In particular, VEGF has been identified as a crucial regulator of both physiologic and pathologic angiogenesis and increased expression of VEGF is associated with a poor prognosis in many types of cancers … Most patients with thyroid cancer have a very good prognosis with treatment (98% 5 year survival rate) involving surgery and hormone therapy.