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Displaying results 911 - 920 of 10000 in total
  1. Target

    A-type voltage-gated potassium channel KCND2

    go.drugbank.com/bio_entities/BE0003603
    TargetHumans

    In vivo, membranes probably contain a mixture of heteromeric potassium channel complexes. … Functions downstream of the metabotropic glutamate receptor GRM5 and plays a role in neuronal excitability and in nociception mediated by activation of GRM5 (By similarity).

    Polypeptides: A-type voltage-gated potassium channel KCND2Function: A-type (transient outward) potassium channel activity
  2. Target

    A-type voltage-gated potassium channel KCND3

    go.drugbank.com/bio_entities/BE0003604
    TargetHumans

    In neurons, may conduct the transient subthreshold somatodendritic A-type potassium current (ISA) (By similarity). … Pore-forming (alpha) subunit of voltage-gated A-type potassium channels that mediates transmembrane potassium transport in excitable membranes, in brain and heart (PubMed:10200233, PubMed:17187064, PubMed

    Polypeptides: A-type voltage-gated potassium channel KCND3Function: A-type (transient outward) potassium channel activity
  3. Target

    A-type voltage-gated potassium channel KCND1

    go.drugbank.com/bio_entities/BE0004726
    TargetHumans

    Exhibits a low-threshold A-type current with a hyperpolarized steady-state inactivation midpoint and the recovery process was steeply voltage-dependent, with recovery being markedly faster at more negative … Mediates A-type current I(SA) in suprachiasmatic nucleus (SCN) neurons.

    Polypeptides: A-type voltage-gated potassium channel KCND1Function: A-type (transient outward) potassium channel activity
  4. Target

    cAMP-dependent protein kinase (Protein kinase A)

    go.drugbank.com/bio_entities/BE0010127
    TargetHumans

    Phosphorylates a large number of substrates in the cytoplasm and the nucleus … Acts as a negative regulator of mTORC1 by mediating phosphorylation of RPTOR (PubMed:31112131)

  5. Drug

    Acetylcysteine

    go.drugbank.com/drugs/DB06151
    ApprovedInvestigational

    [L31378,L31383,L31388,L31478] Acetylcysteine has also been studied for a wide variety of off-label indications with mixed results. … Acetylcysteine is an antioxidant and glutathione inducer indicated for mucolytic therapy and the treatment of [acetaminophen] overdose.

    Synonyms: N-AC, (R)-2-acetylamino-3-mercaptopropanoic acidMixtures: N-ACETILCISTEÍNA 2 G + GUAYACOLATO DE GLICERILO 2 G JARABE, AMINOPLASMAL-5% E INFUSION
  6. Drug

    Cephalexin

    go.drugbank.com/drugs/DB00567
    ApprovedInvestigationalVet approved

    [A179071,A179074] This antibiotic contains a beta lactam and a dihydrothiazide. … [A179071] Cephalexin is used to treat a number of susceptible bacterial infections through inhibition of cell wall synthesis.[A179083,L6547] Cephalexin was approved by the FDA on 4 January 1971.

    Synonyms: (6R,7R)-7-{[(2R)-2-amino-2-phenylacetyl]amino}-3-methyl-8-oxo-5-thia-1-azabicyclo[4.2.0]oct-2-ene-2-carboxylic acid, 7-beta-(D-alpha-Amino-alpha-phenylacetylamino)-3-methyl-3-cephem-4-carboxylic acidInternational brands: L-Keflex
  7. Target

    V-type proton ATPase catalytic subunit A

    go.drugbank.com/bio_entities/BE0003569
    TargetHumans

    Catalytic subunit of the V1 complex of vacuolar(H+)-ATPase (V-ATPase), a multisubunit enzyme composed of a peripheral complex (V1) that hydrolyzes ATP and a membrane integral complex (V0) that translocates … May play a role in neurite development and synaptic connectivity (PubMed:29668857)

    Polypeptides: V-type proton ATPase catalytic subunit ASynonyms: V-ATPase subunit A
  8. Target

    Nuclear receptor subfamily 4immunitygroup A member 1

    go.drugbank.com/bio_entities/BE0010494
    TargetHumans

    Plays a role in the vascular response to injury (By similarity)

    Polypeptides: Nuclear receptor subfamily 4immunitygroup A member 1
  9. Target

    Inositol polyphosphate-4-phosphatase type I A

    go.drugbank.com/bio_entities/BE0018619
    EnzymeHumans

    Catalyzes the hydrolysis of the 4-position phosphate of phosphatidylinositol 3,4-bisphosphate (PtdIns(3,4)P2) (PubMed:15716355, PubMed:20463662). Also catalyzes inositol 1,3,4-trisphosphate and inositol 1,4-bisphosphate (By similarity). ...

    Polypeptides: Inositol polyphosphate-4-phosphatase type I A
  10. Drug

    Insulin detemir

    go.drugbank.com/drugs/DB01307
    ApprovedInvestigational

    , which is a life-threatening medical emergency. … Insulin detemir is a long-acting form of insulin used for the treatment of hyperglycemia caused by Type 1 and Type 2 Diabetes.

    Categories: Cytochrome P-450 CYP1A2 Inducers, Cytochrome P-450 Enzyme InducersProducts: Levemir FlexPen 100U/ML Solution for injection in a prefilled pen, Levemir® FlexPen® 100 U/ml Solution for Injection in Pre-filled Pen