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Combretastatin A4
go.drugbank.com/drugs/DB14680ExperimentalSynonyms: CA4, PHENOL, 2-METHOXY-5-(2-(3,4,5-TRIMETHOXYPHENYL)ETHENYL)-, (Z)-Nuvaxovid
go.drugbank.com/drugs/DB15810ApprovedInvestigationalSARS-CoV-2, the causative agent of COVID-19, relies on the interaction between its trimeric spike (S) glycoprotein and angiotensin-converting enzyme 2 (hACE2) expressed on host cells in order to establish … [L49111] In the fall of 2024, an updated formulation covering the Omicron JN.1 subvariant was approved for use in Canada and the US.[L51394,L51399]
Synonyms: SARS-CoV-2 rS, SARS-CoV-2 rS Nanoparticle VaccineAB-201
go.drugbank.com/drugs/DB18629InvestigationalAB-201 is a CAR-NK cell therapy targeted against HER2.[L48340] It is under investigation for the treatment of HER2-positive cancers, including breast and gastric carcinomas.
Synonyms: Ex vivo expanded allogeneic cord blood-derived NK cells that have been genetically modified to express a HER2-directed CAR and secrete IL-15Leucovorin
go.drugbank.com/drugs/DB00650ApprovedInvestigational[L56092, A257419] Unlike folic acid, leucovorin does not require the enzyme dihydrofolate reductase (DHFR) for activation, allowing it to function even when DHFR is inhibited by drugs like methotrexate … anemias resulting from folate deficiency when oral therapy is not feasible.
Mixtures: NEO CROMATON BICOMPLESSOCategories: Compounds used in a research, industrial, or household setting, Vitamin B ComplexBaloxavir marboxil
go.drugbank.com/drugs/DB13997ApprovedInvestigationalBaloxavir marboxil is an antiviral drug used to treat influenza. More specifically, it is a first-in-class cap-dependent endonuclease inhibitor that works to block influenza virus proliferation. … [A251760] Baloxavir marboxil was first globally approved in Japan in February 2018,[A39895] followed by the US approval in October, 2018.
Categories: P-glycoprotein inhibitors, P-glycoprotein substratesProducts: XOFLUZA 20 MG FİLM KAPLI TABLET, 2 ADET, XOFLUZA 20 MG FİLM KAPLI TABLET, 4 ADETGalactosylgalactosylxylosylprotein 3-beta-glucuronosyltransferase 3
go.drugbank.com/bio_entities/BE0001872TargetHumansCan also play a role in the biosynthesis of l2/HNK-1 carbohydrate epitope on glycoproteins.
Synonyms: GlcAT-I, GlcUAT-ICytochrome P450 2A6
go.drugbank.com/bio_entities/BE0003336TargetEnzymeHumansExhibits a high coumarin 7-hydroxylase activity. Can act in the hydroxylation of the anti-cancer drugs cyclophosphamide, ifosphamide and tegafur.
Synonyms: Cytochrome P450(I), Coumarin 7-hydroxylase3-oxoacyl-[acyl-carrier-protein] synthase 1
go.drugbank.com/bio_entities/BE0000801TargetEscherichia coli (strain K12)Can also use unsaturated fatty acids (PubMed:19679654, PubMed:3076377, PubMed:8910376). … Has an absolute requirement for an ACP substrate as the acyl donor, and no activity is detected when both substrates are based on CoA (PubMed:22017312).
Synonyms: KAS I, Beta-ketoacyl-ACP synthase ITeplizumab
go.drugbank.com/drugs/DB06606ApprovedInvestigationalTeplizumab was designed as an Fc-non-binding antibody in order to reduce the incidence of CRS. … [A241480] On November 2022, teplizumab was approved by the FDA as the first drug that can delay the onset of type 1 diabetes.
Categories: Drugs Used in DiabetesAluminum zirconium tetrachlorohydrex gly
go.drugbank.com/drugs/DB11149ApprovedWithdrawnAluminum zirconium tetrachlorohydrex gly is a common active ingredient in personal care products as an antiperspirant agent. … Its main mechanism of action is through blocking the pores via formation of polymer complex and preventing sweat from leaving the body.
Mixtures: Ban Ultra Antiperspirant Roll-ONProducts: Ban U. Fr. & Dry Wo Ap Roll-ON W Aloe-skiing, No Name Ladies Antip 23% Sport Scent