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Displaying results 921 - 930 of 10000 in total
  1. Pathway

    Cyclophosphamide Action Pathway

    smpdb.ca/view/SMP0000447
    Drug action

    Cyclophosphamide is an alkylating agent used in the treatment of certain cancers. Following absorption, cyclophosphamide is converted into 4-hydroxyphosphamide by a variety of cytochrome P450 isozymes in the liver. 4-Hydroxyphosphamide i...

    Drugs: Glutathione · NADH · Cyclophosphamide · Mesoheme · Acrylic Acid
    Enzymes: Glutathione S-transferase Mu 1
  2. Drug

    Dienogest

    go.drugbank.com/drugs/DB09123
    ApprovedInvestigational

    It is primarily used as a contraceptive in combination with ethinylestradiol, or in other combination form pills approved in United States and Europe however it is not available in the US by itself. … In Europe, Australia, Malaysia, Singapore and Japan, dienogest single therapy is an approved treatment for endometriosis to alleviate painful symptoms of endometriosis and reduce endometriotic lesions

    Mixtures: Foxinette 0,03 mg/2 mg 21+7 - Filmtabletten, Velbienne 1 mg/2 mg FilmtablettenCategories: Cytochrome P-450 Substrates, Cytochrome P-450 CYP3A Substrates
  3. Pathway

    Arsenate Detoxification

    smpdb.ca/view/SMP0121123
    Metabolic

    From here, it forms methylarsonite via the glutathione S-transferase omega-1 enzyme again. … The methylarsonite reacts with S-adenosylmethionine, catalyzed by arsenite methyltransferase, in order to become dimethylarsinate.

    Drugs: Ademetionine · Glutathione
    Enzymes: Glutathione S-transferase omega-1
  4. Pathway

    Gq Serotonergic Smooth Muscle Contraction

    smpdb.ca/view/SMP0126954
    Physiological

    Although numerous GPCRs have the ability to couple to more than one heterotrimeric G protein, a given GPCR is typically classified based on the G protein subfamily (e.g., Gs, Gi/o, or Gq/11) it preferentially activates. Signaling via Gq-...

    Drugs: ATP · Calcium · Magnesium cation
    Enzymes: Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-2
  5. Pathway

    Lysophosphatidic Acid LPA6 Signalling

    smpdb.ca/view/SMP0063759
    Signaling

    Lysophosphatidic acid (LPA) is a water-soluble phospholipid derivative and a potent signalling molecule that binds to six known lysophosphatidic acid receptors (LPARs), named LPA1-LPA6. All six receptors belong to the G protein-coupled r...

    Drugs: ATP · Magnesium cation · Cyclic adenosine monophosphate · Pyrophosphoric acid
    Enzymes: Guanine nucleotide-binding protein G(s) subunit alpha isoforms XLas
  6. Drug

    Sumatriptan

    go.drugbank.com/drugs/DB00669
    ApprovedInvestigational

    [L6793,L6796,L6799,L6805,L6808,L6811] Sumatriptan is the first of the triptans and was made available in Europe in 1991 to treat migraines. … Sumatriptan is a serotonin receptor agonist commonly used to treat migraines and sometimes cluster headaches.

    Synonyms: 1-[3-(2-dimethylaminoethyl)-1H-indol-5-yl]-N-methyl-methanesulfonamide, (3-[2-(dimethylamino)ethyl]-1H-indol-5-yl)-N-methylmethanesulfonamideMixtures: TRASS® TABLETA RECUBIERTA, TRASS® TABLETA RECUBIERTA
  7. Pathway

    Muscular Gs Protein Cascade

    smpdb.ca/view/SMP0126976
    Physiological

    G proteins, also known as guanine nucleotide-binding proteins, are a family of proteins that act as molecular switches inside cells, and are involved in transmitting signals from a variety of stimuli outside a cell to its interior. Their...

    Drugs: ATP · Calcium · Magnesium cation · Cyclic adenosine monophosphate
    Enzymes: Guanine nucleotide-binding protein G(s) subunit alpha isoforms short, Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-1
  8. Drug

    Cyclopentamine

    go.drugbank.com/drugs/DB08999
    ApprovedWithdrawn

    Cyclopentamine is a sympathomimetic alkylamine, classified as a vasoconstrictor. Cyclopentamine was an over the counter treatment for nasal congestion in Europe and Australia. … It has been widely discontinued due to the safety, effectiveness, and availability of a similar drug, propylhexedrine.

  9. Drug

    Maralixibat

    go.drugbank.com/drugs/DB16226
    ApprovedInvestigational

    Use (CHMP) recommended maralixibat be granted marketing authorization for the treatment of cholestatic pruritus in patients with Alagille syndrome:[L43547] it was granted marketing authorization in Europe … Maralixibat (also known as SHP625, LUM001, and lopixibat) is an ileal bile acid transporter inhibitor, like [odevixibat].

    Categories: Cytochrome P-450 CYP3A Inhibitors, Heterocyclic Compounds, 2-Ring
  10. Drug

    Secnidazole

    go.drugbank.com/drugs/DB12834
    ApprovedInvestigational

    [A245503] Secnidazole has been available in many other countries in Europe, Asia, South America, and Africa for decades. … Secnidazole is a second-generation 5-nitroimidazole antimicrobial agent.

    Synonyms: 1-(2-methyl-5-nitro-1H-imidazol-1-yl) propan-2­ ol, 1-(2­ hydroxypropyl)-2-methyl-5-nitroimidazoleMixtures: FUNEX® - S TABLETA, BATEN ® S TABLETAS RECUBIERTAS