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Bepotastine
go.drugbank.com/drugs/DB04890ApprovedBepotastine is a non-sedating, selective antagonist of the histamine 1 (H1) receptor. … The opthalmic solution is FDA approved since Sept 8, 2009 and is under the brand name Bepreve.
Categories: Heterocyclic Compounds, 1-RingProducts: DOLCETTINA®Phenserine
go.drugbank.com/drugs/DB04892InvestigationalPhenserine is a next generation acetylcholinesterase (AChE) inhibitor indicated for the treatment of AD. … Phenserine is under development by Axonyx, a US biopharmaceutical company that focuses on treatments for dementia.
Categories: Heterocyclic Compounds, 2-RingLucinactant
go.drugbank.com/drugs/DB04897ApprovedFDA approved on March 6, 2012. … It contains sinapultide, a novel, hydrophobic, 21-amino acid peptide (leucine and lysine repeating units, KL4 peptide) designed to mimic human surfactant protein-B (SB-P).
Nesiritide
go.drugbank.com/drugs/DB04899ApprovedInvestigationalWithdrawnNesiritide is a 32 amino acid recombinant human B-type natriuretic peptide. … Nesiritide is a medication used to treat acutely decompensated congestive heart failure with dyspnea at rest or with minimal exertion (such as talk, eating or bathing).
Flibanserin
go.drugbank.com/drugs/DB04908ApprovedInvestigationalFlibanserin's mechanism of action is attributed to its high affinity for 5-HTA1 and 5-HTA2 receptors, displaying agonist activity on 5-HTA1 and antagonist on 5-HTA2, resulting in lowering of serotonin … In February of 2018 Flibanserin was approved by Health Canada under the brand name Addyi for a similar indication as approved by the FDA.
Categories: Cytochrome P-450 Substrates, P-glycoprotein inhibitorsRenzapride
go.drugbank.com/drugs/DB04917InvestigationalRenzapride is currently in Phase III clinical development in the United States for the treatment of constipation-predominant irritable bowel syndrome (IBS-C).
Categories: Serotonin 5-HT4 Receptor AgonistsClevidipine
go.drugbank.com/drugs/DB04920ApprovedInvestigationalClevidipine is a dihydropyridine L-type calcium channel blocker that is selective for vascular smooth muscle and is indicated for blood pressure reduction when oral therapy is not an option.
Categories: Cytochrome P-450 Substrates, Cytochrome P-450 CYP3A InducersDesmoteplase
go.drugbank.com/drugs/DB04925InvestigationalDesmoteplase is a recombinant form of vampire bat DSPA (Salivary plasminogen activator alpha 1). … When a vampire bat bites its victim, it secretes an enzyme that prevents the blood from clotting.
Synonyms: rDSPA alpha 1, Salivary plasminogen activator alpha 1, Desmodus rotundusCrofelemer
go.drugbank.com/drugs/DB04941ApprovedInvestigationalCrofelemer, previously known as the investigational drug SP-303, is a novel proanthocyanidin purified from the bark latex of the Amazonian Croton tree <i>Croton lechleri</i>.
Categories: Heterocyclic Compounds, 1-Ring, Heterocyclic Compounds, 2-RingTamibarotene
go.drugbank.com/drugs/DB04942InvestigationalTamibarotene is a novel synthetic retinoid for acute promyelocytic leukaemia (APL).