Bepotastine is an ophthalmic H1 antagonist used to treat itchiness associated with allergic conjunctivitis. Bepotastine is a non-sedating, selective antagonist of the histamine 1 (H1) receptor.
- Mechanism
- Curator reviewed
Because of a type 1 hypersensitivity reaction cascade that is triggered by antigen exposure, allergic conjunctivitis occurs. Allergen exposure is followed by conjunctival mast cell degranulation and histamine released as a result of the formation of complementary IgE cross-links on the conjunctiva. Due to the release of histamine, symptoms such as itching can be observed. Bepotastine works to relieve itchy eyes by three primary mechanisms of action. It is a non-sedating, selective antagonist of the histamine 1 (H1) receptor, a mast cell stabilizer, and it suppresses the migration of eosinophils into inflamed tissues to prevent tissue damage and worsening of allergic inflammation of the conjunctiva.
- Primary indication
- For the symptomatic treatment of itchy eyes (caused by IgE-induced mast cell degranulation) due to allergic conjunctivitis.Curator reviewed · 1 structured indication
- Formula / weight
- C21H25ClN2O3 · 388.888 g/mol (avg)
- First approval
- Canada, 2016 · United States, 2009
- Code names
- TAU-284DS
- Brand names
Resolves to
YWGDOWXRIALTES-UHFFFAOYSA-NSMILESOC(=O)CCCN1CCC(CC1)OC(C1=CC=C(Cl)C=C1)C1=CC=CC=N1What you can answer from here — as of October 01, 2026
Which drugs share a target with Bepotastine, and which of those have an active Phase 3 trial?
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