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Cyclophosphamide Metabolism Pathway
smpdb.ca/view/SMP0000604Drug metabolismCyclophosphamide is an alkylating agent used in the treatment of certain cancers. Following absorption, cyclophosphamide is converted into 4-hydroxyphosphamide by a variety of cytochrome P450 isozymes in the liver. 4-Hydroxyphosphamide i...
Enzymes: Glutathione S-transferase Mu 1Secobarbital
go.drugbank.com/drugs/DB00418ApprovedVet approvedIt is commonly known as quinalbarbitone in the United Kingdom. … Secobarbital (marketed by Eli Lilly and Company under the brand names Seconal and Tuinal) is a barbiturate derivative drug with anaesthetic, anticonvulsant, sedative and hypnotic properties.
Categories: Cytochrome P-450 CYP1A2 Inducers, Cytochrome P-450 CYP2C8 InducersSynonyms: 5-(1-methylbutyl)-5-(2-propenyl)-2,4,6(1H,3H,5H)-pyrimidinetrione, 5-allyl-5-(1-methylbutyl)barbituric acidThiopental
go.drugbank.com/drugs/DB00599ApprovedInvestigationalVet approvedWithdrawnA barbiturate that is administered intravenously for the induction of general anesthesia or for the production of complete anesthesia of short duration. … It is also used for hypnosis and for the control of convulsive states. It has been used in neurosurgical patients to reduce increased intracranial pressure.
Categories: Cytochrome P-450 CYP2C19 Substrates with a Narrow Therapeutic Index, Cytochrome P-450 SubstratesSynonyms: 2-Thio-5-ethyl-5-sec-pentylbarbituric acid, 5-Ethyl-5-(1-methyl-butyl)-2-thioxo-dihydro-pyrimidine-4,6-dioneMethyprylon
go.drugbank.com/drugs/DB01107ApprovedIllicitWithdrawnMethyprylon is a sedative of the piperidinedione derivative family that was previously used for the treatment of insomnia. … However, with the introduction of newer drugs with fewer side effects, such as benzodiazepines, the clinical use of methyprylon is now limited.
Categories: Heterocyclic Compounds, 1-RingEpoprostenol Action Pathway
smpdb.ca/view/SMP0126492Drug actionEpoprostenol is a platelet aggregator inhibitor also known under the brand name of Flolan and Veletri, used to manage hypertension in patients with heart failure. It is synthesized from prostaglandin endoperoxides in human vascular tissu...
Enzymes: Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-1Lafutidine H2 Anti-Histamine Action Pathway
smpdb.ca/view/SMP0051038Drug actionLafutidine (also known as INN) is a second generation histamine H2 receptor antagonist that can be used for treating ulcers and reflux. Inhibition of histamine H2 receptor can inhibit histamine-stimulated gastric acid secretion which wil...
Enzymes: Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-12, Guanine nucleotide-binding protein G(s) subunit alpha isoforms shortMetipranolol
go.drugbank.com/drugs/DB01214ApprovedWithdrawnA beta-adrenergic antagonist effective for both beta-1 and beta-2 receptors. It is used as an antiarrhythmic, antihypertensive, and antiglaucoma agent.
Synonyms: Acetic acid 4-(2-hydroxy-3-isopropylamino-propoxy)-2,3,6-trimethyl-phenyl esterCategories: Cytochrome P-450 Substrates, Cytochrome P-450 CYP2D6 SubstratesDienogest
go.drugbank.com/drugs/DB09123ApprovedInvestigationalIt is primarily used as a contraceptive in combination with ethinylestradiol, or in other combination form pills approved in United States and Europe however it is not available in the US by itself. … In Europe, Australia, Malaysia, Singapore and Japan, dienogest single therapy is an approved treatment for endometriosis to alleviate painful symptoms of endometriosis and reduce endometriotic lesions
Synonyms: 17-alpha-Cyanomethyl-17-beta-hydroxy-estra-4,9(10)-dien-3-one, 17alpha-17-Hydroxy-3-oxo-19-norpregna-4,9-diene-21-nitrileMixtures: Foxinette 0,03 mg/2 mg 21+7 - Filmtabletten, Velbienne 1 mg/2 mg FilmtablettenGi Muscarinic Cardiac Muscle Contraction
smpdb.ca/view/SMP0126951PhysiologicalThe M2 muscarinic receptors are located in the heart, where they act to slow the heart rate down to normal sinus rhythm after negative stimulatory actions of the parasympathetic nervous system, by slowing the speed of depolarization. The...
Enzymes: Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-12, Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-1Cyclophosphamide Action Pathway
smpdb.ca/view/SMP0000447Drug actionCyclophosphamide is an alkylating agent used in the treatment of certain cancers. Following absorption, cyclophosphamide is converted into 4-hydroxyphosphamide by a variety of cytochrome P450 isozymes in the liver. 4-Hydroxyphosphamide i...
Enzymes: Glutathione S-transferase Mu 1