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Alteplase
go.drugbank.com/drugs/DB00009ApprovedInvestigationalAlteplase is a recombinant tissue plasminogen activator (rt-PA) used as a thrombolytic agent.[L43125] It cleaves plasminogen to form plasmin, an enzyme involved in the degradation of fibrin clots. … [A252330,L43125] Alteplase is a purified glycoprotein of 527 amino acids expressed in Chinese hamster ovary (CHO) cells.
Synonyms: t-PA, r-tPAProducts: Activase RT-PA Inj, ACTILYSE 20 MG FLAKON, 1 ADETMitomycin
go.drugbank.com/drugs/DB00305ApprovedInvestigational[A193419] Mitomycin's cross-linking activity has resulted in its approval for the treatment of a variety of cancers - the most recent of which is an April 2020 approval for its use in low-grade Upper … Mitomycin is an antineoplastic antibiotic first isolated by Japanese microbiologists in the 1950s from cultures of _Streptomyces caespitosus_.
Categories: Compounds used in a research, industrial, or household setting, Heterocyclic Compounds, 1-RingSynonyms: Mito-C, Mitocin-CSodium iodide
go.drugbank.com/drugs/DB11119ApprovedInvestigationalSodium iodide is a source of iodine and can be administered as a supplement for total parenteral nutrition [L2065] but is more commonly used in veterinary medicine. … Sodium iodide is a water-soluble ionic compound with a crystal lattice.
Mixtures: FERTOMCIDINA U, FERTOMCIDINA UProducts: Micro I, Sodium Iodide Inj 100mg/mlKetotifen
go.drugbank.com/drugs/DB00920ApprovedInvestigational[A231204] In the US, it is now used in an over-the-counter ophthalmic formulation for the treatment of itchy eyes associated with allergies,[L32278] and in Canada a prescription-only oral formulation is … It has a similar structure to some other first-generation antihistamines such as [cyproheptadine] and [azatadine].
Categories: Heterocyclic Compounds, 1-RingProducts: Zaditen konservierungsmittelfrei 0,025% - Augentropfen in Einzeldosisbehältnissen, Ketotifen Stulln 250 Mikrogramm/ml Augentropfen im EinzeldosisbehältnisLeuprolide
go.drugbank.com/drugs/DB00007ApprovedInvestigational[A203126, A203132] Leuprolide was first approved in 1985 as a daily subcutaneous injection under the tradename Lupron™ by Abbvie Endocrine Inc. … [L13781, L13790] Leuprolide remains frontline therapy in all conditions for which it is indicated for use.
International brands: Prostap 3Products: LUCRIN DEPOT-3 M 11,25 IM/SC ENJEKSIYONLUK FLAKON, 1 ADET, LUCRIN DEPOT-3,75 MG IM/SC ENJEKSIYONLUK FLAKON, 1 ADETFluticasone propionate
go.drugbank.com/drugs/DB00588ApprovedInvestigationalFluticasone propionate is a synthetic glucocorticoid[F4355,F4358][FDA Label]. … Fluticasone propionate was first approved in 1990[L5962].
Mixtures: SALMETEROLO E FLUTICASONE SF, SALMETEROLO E FLUTICASONE SFCategories: P-glycoprotein substrates, Cytochrome P-450 SubstratesVerapamil
go.drugbank.com/drugs/DB00661ApprovedInvestigationalinto therapy in the early 1960s. … Verapamil is a phenylalkylamine calcium channel blocker used in the treatment of high blood pressure, heart arrhythmias, and angina,[L8791] and was the first calcium channel antagonist to be introduced
Mixtures: Trandolapril and Verapamil Hydrochloride ER, Trandolapril and Verapamil Hydrochloride ERCategories: MATE 1 Inhibitors, MATE 2 InhibitorsRelapsed Multiple Myeloma
go.drugbank.com/conditions/DBCOND0031510Drugs: Belantamab mafodotin · Carfilzomib · Ciltacabtagene autoleucel · Daratumumab · Dexamethasone · Elranatamab +8 moreSynonyms: Multiple Myeloma in RelapseBortezomib
go.drugbank.com/drugs/DB00188ApprovedInvestigational[L14180] However, multiple mechanisms may be involved in the anticancer activity of bortezomib.[A204083] Bortezomib was first synthesized in 1995. … [A204146] Phase I, II, III, and IV clinical trials are undergoing to investigate the therapeutic efficacy of bortezomib in leukemia, myasthenia gravis, systemic lupus erythematosus, rheumatoid arthritis
Categories: P-glycoprotein substrates with a Narrow Therapeutic Index, Cytochrome P-450 CYP1A2 Substrates with a Narrow Therapeutic IndexSynonyms: N-[(1R)-1-(DIHYDROXYBORYL)-3-methylbutyl]-N-(pyrazin-2-ylcarbonyl)-L-phenylalaninamide, [(1R)-3-methyl-1-({(2S)-3-phenyl-2-[(pyrazin-2-ylcarbonyl)amino]propanoyl}amino)butyl]boronic acidKeratoconjunctivitis Sicca (KCS)
go.drugbank.com/conditions/DBCOND0105777Drugs: Hydroxypropyl celluloseSynonyms: Keratoconjunctivitis sicca, in Sjögren syndrome, Keratoconjunctivitis sicca, in Sjogren's syndrome