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Displaying results 941 - 950 of 10000 in total
  1. Drug

    Chloroquine

    go.drugbank.com/drugs/DB00608
    ApprovedInvestigationalVet approved

    Chloroquine is an aminoquinolone derivative first developed in the 1940s for the treatment of malaria. … [A192432] **The FDA emergency use authorization for [hydroxychloroquine] and chloroquine in the treatment of COVID-19 was revoked on 15 June 2020.

    Products: OROQUİNE 250 MG/5 ML IV İNFÜZYONLUK ÇÖZELTİ , 10 ADET
  2. Drug

    Atamparib

    go.drugbank.com/drugs/DB19028
    Investigational

    Atamparib is under investigation in clinical trial NCT05127590 (RBN-2397 in Combination With Pembrolizumab in Patients With SCCL).

    Synonyms: 5-(((2s)-1-(3-oxo-3-(4-(5-(trifluoromethyl)pyrimidin-2- yl)piperazin-1-yl)propoxy)propan-2-yl)amino)-4- (trifluoromethyl)pyridazin-3(2h)-one
  3. Indication

    Otoferlin Gene-mediated Hearing Loss

    go.drugbank.com/conditions/DBCOND0170571
    Drugs: Lunsotogene parvec
    Synonyms: Congenital Hearing Loss Secondary to Biallelic Mutations in the Otoferlin Gene (OTOF)
  4. Indication

    Polyneuropathies

    go.drugbank.com/conditions/DBCOND0030109
    Drugs: Vutrisiran
    Synonyms: Other neurologic disorders in Lyme disease
  5. Indication

    Elevation of serum triglyceride levels

    go.drugbank.com/conditions/DBCOND0097366
    Drugs: Atorvastatin · Lovastatin · Pitavastatin · Pravastatin
    Synonyms: Increases in triglycerides, Increase in blood triglycerides
  6. Drug

    Methyldopa

    go.drugbank.com/drugs/DB00968
    ApprovedInvestigational

    [A1499] Methyldopa exists in two isomers D-α-methyldopa and L-α-methyldopa, which is the active form. … Methyldopa, or α-methyldopa, is a centrally acting sympatholytic agent and an antihypertensive agent.

    Synonyms: L-Methyl Dopa, α-methyl-L-dopaCategories: Aromatic L-amino Acid Decarboxylase Inhibitors
  7. Drug

    Clarithromycin

    go.drugbank.com/drugs/DB01211
    ApprovedInvestigational

    Clarithromycin may be bacteriostatic or bactericidal depending on the organism and drug concentration. … Clarithromycin, a semisynthetic macrolide antibiotic derived from erythromycin, inhibits bacterial protein synthesis by binding to the bacterial 50S ribosomal subunit.

    Synonyms: CLA, 6-O-methylerythromycin AMixtures: Aa-lansoprazole-amoxicillin-clarithromycin
  8. Target

    Interferon-inducible protein AIM2

    go.drugbank.com/bio_entities/BE0011287
    TargetHumans

    Inflammasomes are supramolecular complexes that assemble in the cytosol in response to pathogens and other damage-associated signals and play critical roles in innate immunity and inflammation (PubMed: … Also acts as a regulator of neurodevelopment via its role in the DNA damage response: acts by promoting neural cell death in response to DNA damage in the developing brain, thereby purging genetically

    Synonyms: Absent in melanoma 2
  9. Drug

    Sirpiglenastat

    go.drugbank.com/drugs/DB17536
    Investigational

    Sirpiglenastat, also known as DRP-104, is a prodrug of [6-diazo-5-oxo-L-norleucine] (DON), which is a broad-acting glutamine antagonist. … It is under investigation in clinical trial NCT04471415 (Study to Investigate DRP-104 in Adults With Advanced Solid Tumors).

    Synonyms: Propan-2-yl (2s)-2-((n-acetyl-l-tryptophyl)amino)-6-diazo-5-oxohexanoate, L-norleucine, n-acetyl-l-tryptophyl-6-diazo-5-oxo-, 1-methylethyl ester
  10. Drug

    Conjugated estrogens

    go.drugbank.com/drugs/DB00286
    ApprovedInvestigational

    [T475] The conjugated estrogen mixture was approved for marketing in US in 1942 based on the efficacy against certain conditions. … It also presents a large number of unidentified molecules with weak estrogenic activity as well as non-human molecules when it is obtained from pregnant mares urine.

    Products: Premarin Inj 25mg/5ml