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Displaying results 951 - 960 of 10000 in total
  1. Target

    Creatine Kinases

    go.drugbank.com/bio_entities/BE0009627
    EnzymeTargetHumans

    Reversibly catalyzes the transfer of phosphate between ATP and various phosphogens (e.g. creatine phosphate) (PubMed:8186255). Creatine kinase isoenzymes play a central role in energy transduction in tissues with large, fluctuating energ...

    Synonyms: S-MtCKPolypeptides: Creatine kinase S-type, mitochondrial
  2. Indication

    Hodgkin's Lymphoma

    go.drugbank.com/conditions/DBCOND0030382
    Drugs: Bleomycin · Chlorambucil · Cyclophosphamide · Dacarbazine · Doxorubicin · Gemcitabine +5 more
    Synonyms: Hodgkin´s Lymphomas, Hodgkin´s Lymphoma
  3. Drug

    Brinzolamide

    go.drugbank.com/drugs/DB01194
    Approved

    [L35310,L35315] In Europe, it was also approved as a combination product with timolol in 2008.[L35320] … Brinzolamide is a highly specific, non-competitive, reversible carbonic anhydrase II (CA-II) inhibitor indicated to reduce ocular pressure in patients with ocular hypertension or open-angle glaucoma.

    Mixtures: BRİTİL-T 10 MG/ML + 5 MG/ML GÖZ DAMLASI, SÜSPANSİYON, 1 ADET, BRINZOLAMIDE E TIMOLOLO EGCategories: Cytochrome P-450 Substrates, Cytochrome P-450 CYP2A6 Substrates
  4. Target

    Quinoprotein glucose dehydrogenase B

    go.drugbank.com/bio_entities/BE0001728
    TargetEnzymeAcinetobacter calcoaceticus

    Oxidizes glucose to gluconolactone.

    Synonyms: s-GDH
  5. Drug

    Urea

    go.drugbank.com/drugs/DB03904
    ApprovedInvestigational

    A compound formed in the liver from ammonia produced by the deamination of amino acids. … It is the principal end product of protein catabolism and constitutes about one half of the total urinary solids.

    Mixtures: Ti-U-lac Lotion, Ti-U-lac HC LotionProducts: Uramaxin TS, RE Urea
  6. Drug

    Ostrea edulis shell

    go.drugbank.com/drugs/DB14251
    Investigational

    Ostrea edulis shell is an animal extract used in some OTC (over-the-counter) products. It is not an approved drug.

    Synonyms: European Flat Oyster Shell
  7. Drug

    Etoposide

    go.drugbank.com/drugs/DB00773
    ApprovedInvestigational

    Accumulated breaks in DNA prevent entry into the mitotic phase of cell division, and lead to cell death. Etoposide acts primarily in the G2 and S phases of the cell cycle. … A semisynthetic derivative of podophyllotoxin that exhibits antitumor activity. Etoposide inhibits DNA synthesis by forming a complex with topoisomerase II and DNA.

    Categories: P-glycoprotein substrates with a Narrow Therapeutic Index, Cytochrome P-450 CYP1A2 Substrates with a Narrow Therapeutic IndexSynonyms: 9-((4,6-O-Ethylidine-beta-D-glucopyranosyl)oxy)-5,8,8a,9-tetrahydro-5-(4-hydroxy-3,4-dimethyloxyphenyl)furo(3',4'':6,7)naptho-(2,3-d)-1,3-dioxol-6(5aH)-one, 4'-Demethylepipodophyllotoxin 9-(4,6-O-(R)-ethylidene-beta-D-glucopyranoside)
  8. Drug

    Alisertib

    go.drugbank.com/drugs/DB05220
    Investigational

    Alisertib is a novel aurora A kinase inhibitor under investigation for the treatment of various forms of cancer.

    Categories: Heterocyclic Compounds, 1-Ring
  9. Target

    Glutamate mutase sigma subunit

    go.drugbank.com/bio_entities/BE0001771
    TargetClostridium tetanomorphum

    Catalyzes the carbon skeleton rearrangement of L-glutamate to L-threo-3-methylaspartate ((2S,3S)-3-methylaspartate).

    Synonyms: Glutamate mutase S chain
  10. Target

    Anamorsin

    go.drugbank.com/bio_entities/BE0015312
    TargetHumans

    Component of the cytosolic iron-sulfur (Fe-S) protein assembly (CIA) machinery required for the maturation of extramitochondrial Fe-S proteins. … Part of an electron transfer chain functioning in an early step of cytosolic Fe-S biogenesis, facilitating the de novo assembly of a [4Fe-4S] cluster on the scaffold complex NUBP1-NUBP2.

    Synonyms: Fe-S cluster assembly protein DRE2 homolog