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Nelfinavir
go.drugbank.com/drugs/DB00220ApprovedInvestigationalNelfinavir is a potent HIV-1 protease inhibitor. It is used in combination with other antiviral drugs in the treatment of HIV in both adults and children.
Categories: P-glycoprotein inducers, P-glycoprotein inhibitorsIsoetharine
go.drugbank.com/drugs/DB00221ApprovedIsoetharine is a relatively selective beta-2 adrenergic agonist. It is a catechol-like agent. Isoetharine is a fast-acting bronchodilator used for emphysema, bronchitis and asthma.[A330]
Categories: Adrenergic beta-2 Receptor Agonists, Selective Beta 2-adrenergic AgonistsGlimepiride
go.drugbank.com/drugs/DB00222ApprovedInvestigationalIt is sometimes classified as a third-generation SU because it has larger substitutions than other second-generation SUs. … Compared to [glipizide], another second SU drug, glimepiride has a longer duration of action.
Mixtures: AMARYL® M SR, AMARYL® M SRCategories: Cytochrome P-450 Substrates, Cytochrome P-450 CYP2C9 SubstratesDiflorasone
go.drugbank.com/drugs/DB00223ApprovedDiflorasone is a topical corticosteroid used to treat itching and inflammation of the skin.
International brands: Florone EProducts: Psorcon E, ApexiCon EEnflurane
go.drugbank.com/drugs/DB00228ApprovedVet approvedWithdrawnEnflurane is a halogenated inhalational anesthetic initially approved by the FDA in 1972. Since this date, it has been withdrawn from the US market. … In addition, it is known to cause increased cardio depressant effects when compared to other inhaled anesthetics.[A202022]
Categories: Cytochrome P-450 Substrates, Cytochrome P-450 CYP2E1 SubstratesSynonyms: 2-chloro-1,1,2-trifluoroethyl difluoromethyl etherTemazepam
go.drugbank.com/drugs/DB00231ApprovedTemazepam, like many other similar and related benzodiazepines, acts as a gamma-aminobutyric acid (GABA) modulator and is capable of eliciting a variety of actions including sedation, hypnosis, skeletal … In particular, before temazepam saw regular prescription use in civilians it was - and still is - employed by the US military as a sedative-hypnotic medication to be taken by soldiers, pilots, etc. to
Categories: Cytochrome P-450 Substrates, Cytochrome P-450 CYP2B6 SubstratesMilrinone
go.drugbank.com/drugs/DB00235ApprovedInvestigationalHeart failure is a multifactorial condition that affects roughly 1-2% of the adult population. … [A228323] Milrinone is a second-generation bipyridine phosphodiesterase (PDE) inhibitor created through chemical modification of [amrinone].
Categories: Heterocyclic Compounds, 1-Ring, Phosphodiesterase 3 InhibitorsSynonyms: 1,6-Dihydro-2-methyl-6-oxo(3,4'-bipyridine)-5-carbonitrileAlclometasone
go.drugbank.com/drugs/DB00240ApprovedAlclometasone is synthetic glucocorticoid steroid for topical use in dermatology as anti-inflammatory, antipruritic, antiallergic, antiproliferative and vasoconstrictive agent.
Categories: Cytochrome P-450 Substrates, Cytochrome P-450 CYP3A SubstratesSynonyms: (7alpha,11beta,16alpha)-7-chloro-11,17,21-trihydroxy-16-methylpregna-1,4-diene-3,20-dioneZiprasidone
go.drugbank.com/drugs/DB00246ApprovedInvestigationalgenerally thought to be as efficacious as first generation antipsychotics but differ in their adverse effect profiles. … [A180748] Although ziprasidone is classified as an atypical antipsychotic, it appears to have a lower incidence of metabolic adverse effects compared to other medications in the same class.[A190525]
Categories: Cytochrome P-450 Substrates, Adrenergic alpha-1 Receptor AntagonistsProducts: GEODON® CAPSULAS 80 MG, ICIN KURU TOZ ICEREN FLAKON 20MG/ML FLAKON, 1 ADETMethysergide
go.drugbank.com/drugs/DB00247ApprovedWithdrawnAn ergot derivative that is a congener of lysergic acid diethylamide. … Methysergide is used prophylactically in migraine and other vascular headaches and to antagonize serotonin in the carcinoid syndrome.
Categories: Cytochrome P-450 Substrates, Cytochrome P-450 CYP3A SubstratesSynonyms: (+)-N-(1-(Hydroxymethyl)propyl)-1-methyl-D-lysergamide, 1-Methyl-dextro-lysergic acid (+)-1-hydroxy-2-butylamide