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Propylene glycol Drug Metabolism
smpdb.ca/view/SMP0130507MetabolicPropylene glycol passes through the liver and is then excreted from the body mainly through the kidney. … Propylene glycol is a drug that is not metabolized by the human body as determined by current research and biotransformer analysis.
Drugs: Propylene glycolPyruvate Metabolism
smpdb.ca/view/SMP0000060MetabolicIt can be formed from glucose via glycolysis or the transamination of alanine. … In glycolysis, phosphoenolpyruvate (PEP) is converted to pyruvate by pyruvate kinase in an highly exergonic and irreversible reaction.
Pyruvate Dehydrogenase Complex Deficiency
smpdb.ca/view/SMP0125772DiseaseThis conversion step links glycolysis and the citric acid cycle. … PDHA1 encodes the pyruvate dehydrogenase complex (PDC) a critical complex that converts pyruvate from glycolysis to acetyl CoA for the citric acid cycle.
Pyruvate Kinase Deficiency
smpdb.ca/view/SMP0000559DiseasePyruvate kinase deficiency is a genetic disorder. It affects red blood cells in the body. Patients are affected by a condition called chronic hemolytic anemia, which is where red blood cells undergo hemolysis before they are meant to whi...
Pyruvate Dehydrogenase Complex Deficiency
smpdb.ca/view/SMP0000212DiseaseThis conversion step links glycolysis and the citric acid cycle. … PDHA1 encodes the pyruvate dehydrogenase complex (PDC) a critical complex that converts pyruvate from glycolysis to acetyl CoA for the citric acid cycle.
Leigh Syndrome
smpdb.ca/view/SMP0000196DiseaseLeigh Syndrome, also called Leigh Disease or infantile subacute necrotizing encephalopathy, is a rare inborn error of metabolism (IEM) and autosomal recessive disorder that is caused by a mutation of any one of 75 different genes. Disrup...
Primary Hyperoxaluria II, PH2
smpdb.ca/view/SMP0000558DiseasePrimary hyperolaria type 2 (PH2) is a rare condition resulting from glyoxylate reductase/hydroxypyruvate reductase (GR/HPR) enzyme deficiency. PH2 results in calcium oxalate (also known as oxalic acid) deposits and end-stage renal diseas...
Pyruvate Decarboxylase E1 Component Deficiency (PDHE1 Deficiency)
smpdb.ca/view/SMP0125771DiseasePyruvate Decarboxylase E1 Component Deficiency is caused by a defect in the PDHA1 gene which codes for mitochondrial pyruvate dehydrogenase E1 component subunit alpha, somatic form. This is a homotetrameric enzyme that catalyses the deca...
Pyruvate Kinase Deficiency
smpdb.ca/view/SMP0125774DiseasePyruvate kinase deficiency is a genetic disorder. It affects red blood cells in the body. Patients are affected by a condition called chronic hemolytic anemia, which is where red blood cells undergo hemolysis before they are meant to whi...
Pyruvate Decarboxylase E1 Component Deficiency (PDHE1 Deficiency)
smpdb.ca/view/SMP0000334DiseasePyruvate Decarboxylase E1 Component Deficiency is caused by a defect in the PDHA1 gene which codes for mitochondrial pyruvate dehydrogenase E1 component subunit alpha, somatic form. This is a homotetrameric enzyme that catalyses the deca...