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Displaying results 1 - 10 of 27 in total
  1. Drug

    Tenofovir disoproxil

    go.drugbank.com/drugs/DB00300
    ApprovedInvestigational

    Tenofovir disoproxil fumarate (a prodrug of tenofovir), marketed by Gilead Sciences under the trade name _Viread_, belongs to a class of antiretroviral drugs known as nucleotide analogue reverse transcriptase … Tenofovir disoproxil was initially approved in 2001 [FDA label].

    Synonyms: Tenofovir bis(isopropyloxycarbonyloxymethyl) esterSalts: Tenofovir disoproxil fumarate, Tenofovir disoproxil maleate
  2. Drug

    Tenofovir alafenamide

    go.drugbank.com/drugs/DB09299
    ApprovedInvestigational

    Tenofovir alafenamide is a novel [tenofovir] prodrug developed in order to improve renal safety when compared to the counterpart [tenofovir disoproxil]. … [A178219] It has been reported to produce a large antiviral efficacy at doses ten times lower than tenofovir disoproxil.

    Synonyms: Tenofovir alafenamideSalts: Tenofovir alafenamide fumarate
  3. Pathway

    Tenofovir Disoproxil Action Pathway

    smpdb.ca/view/SMP0125902
    Drug action

    Tenofovir disoproxil fumarate is the fumarate salt of the prodrug tenofovir disoproxil. … Tenofovir disoproxil is absorbed and converted to its active form, tenofovir, a nucleoside monophosphate (nucleotide) analog.

    Drugs: ATP · Tenofovir disoproxil · Magnesium cation · Formaldehyde · Maleic acid
  4. Pathway

    Tenofovir Metabolism Pathway

    smpdb.ca/view/SMP0000630
    Drug metabolism

    Tenofovir is a nucleotide analogue used in the treatment of HIV and chronic hepatitis B. … Once incorporated into the DNA, tenofovir causes chain termination, thus preventing viral replication.

    Drugs: ATP · Tenofovir disoproxil · Magnesium cation
  5. Pathway

    Tenofovir Alafenamide Action Pathway

    smpdb.ca/view/SMP0125907
    Drug action

    Tenofovir alafenamide is a novel tenofovir prodrug nucleoside analog reverse transcriptase inhibitor developed in order to improve renal safety when compared to the counterpart tenofovir disoproxil. … In the liver, tenofovir alafenamide is converted into tenofovir alanine by the enzymes Lysosomal protective protein and Liver carboxylesterase 1.Tenofovir alanine is then converted to Tenofovir by the

    Drugs: Alanine · ATP · Tenofovir disoproxil · Magnesium cation · Tenofovir alafenamide
  6. Pathway

    Tenofovir Action Pathway (New)

    smpdb.ca/view/SMP0124939
    Drug action

    Nucleoside diphosphate kinase then converts tenofovir monophosphate into tenofovir diphosphate. Tenofovir diphosphate is an analog of deoxyadenosine triphosphate (dATP). … Tenofovir enters the cell via solute carrier family 22 member 8 and is converted into tenofovir monophosphate by adenylate kinase.

    Drugs: ATP · Tenofovir disoproxil · Magnesium cation
  7. Drug

    Emtricitabine

    go.drugbank.com/drugs/DB00879
    ApprovedInvestigational

    Emtricitabine is a nucleoside reverse transcriptase inhibitor (NRTI) indicated for the treatment of HIV infection in adults[L9019] or combined with [tenofovir alafenamide] for the prevention of HIV-1 infection

    Mixtures: Emtricitabine and Tenofovir Disoproxil Fumarate, Emtricitabine and Tenofovir Disoproxil FumarateCategories: tenofovir disoproxil and emtricitabine, emtricitabine, tenofovir disoproxil and efavirenz
  8. Drug

    Efavirenz

    go.drugbank.com/drugs/DB00625
    ApprovedInvestigational

    For HIV infection that has not previously been treated, efavirenz and lamivudine in combination with zidovudine or tenofovir is the preferred NNRTI-based regimen.

    Mixtures: Efavirenz, Lamivudine and Tenofovir Disoproxil Fumarate, Efavirenz, Lamivudine and Tenofovir Disoproxil FumarateCategories: lamivudine, tenofovir disoproxil and efavirenz, emtricitabine, tenofovir disoproxil and efavirenz
  9. Drug

    Doravirine

    go.drugbank.com/drugs/DB12301
    ApprovedInvestigational

    [L12729,L4562] Doravirine is available by itself or as a combination product of doravirine (100 mg), lamivudine (300 mg), and tenofovir disoproxil fumarate (300 mg).

    Categories: lamivudine, tenofovir disoproxil and doravirine
  10. Drug

    Lamivudine

    go.drugbank.com/drugs/DB00709
    ApprovedInvestigational

    A reverse transcriptase inhibitor and zalcitabine analog in which a sulfur atom replaces the 3' carbon of the pentose ring. It is used to treat Human Immunodeficiency Virus Type 1 (HIV-1) and hepatitis B (HBV).

    Mixtures: Efavirenz, Lamivudine and Tenofovir Disoproxil Fumarate, Efavirenz, Lamivudine and Tenofovir Disoproxil FumarateCategories: lamivudine and tenofovir disoproxil, lamivudine, tenofovir disoproxil and efavirenz