Search

Displaying results 1 - 10 of 13 in total
  1. Pathway

    Tenofovir Disoproxil Action Pathway

    smpdb.ca/view/SMP0125902
    Drug action

    Tenofovir disoproxil fumarate is the fumarate salt of the prodrug tenofovir disoproxil. … Tenofovir disoproxil is absorbed and converted to its active form, tenofovir, a nucleoside monophosphate (nucleotide) analog.

    Drugs: ATP · Tenofovir disoproxil · Magnesium cation · Formaldehyde · Maleic acid
  2. Pathway

    Tenofovir Metabolism Pathway

    smpdb.ca/view/SMP0000630
    Drug metabolism

    Tenofovir is a nucleotide analogue used in the treatment of HIV and chronic hepatitis B. … Once incorporated into the DNA, tenofovir causes chain termination, thus preventing viral replication.

    Drugs: ATP · Tenofovir disoproxil · Magnesium cation
  3. Pathway

    Tenofovir Alafenamide Action Pathway

    smpdb.ca/view/SMP0125907
    Drug action

    Tenofovir alafenamide is a novel tenofovir prodrug nucleoside analog reverse transcriptase inhibitor developed in order to improve renal safety when compared to the counterpart tenofovir disoproxil. … In the liver, tenofovir alafenamide is converted into tenofovir alanine by the enzymes Lysosomal protective protein and Liver carboxylesterase 1.Tenofovir alanine is then converted to Tenofovir by the

    Drugs: Alanine · ATP · Tenofovir disoproxil · Magnesium cation · Tenofovir alafenamide
  4. Pathway

    Tenofovir Action Pathway (New)

    smpdb.ca/view/SMP0124939
    Drug action

    Nucleoside diphosphate kinase then converts tenofovir monophosphate into tenofovir diphosphate. Tenofovir diphosphate is an analog of deoxyadenosine triphosphate (dATP). … Tenofovir enters the cell via solute carrier family 22 member 8 and is converted into tenofovir monophosphate by adenylate kinase.

    Drugs: ATP · Tenofovir disoproxil · Magnesium cation
  5. Pathway

    Efavirenz Action Pathway

    smpdb.ca/view/SMP0000740
    Drug action

    Efavirenz (also known as Sustiva) is a nucleoside reverse transcriptase inhibitor (NRTI) for treating HIV infection by inhibiting the transcriptase reversibly. Efavirenz is phosphorylated to its active triphosphorylated form so that it c...

    Drugs: Efavirenz
  6. Pathway

    Lamivudine Action Pathway

    smpdb.ca/view/SMP0000742
    Drug action

    Lamivudine (also known as 3TC) is an antiretroviral drug that can be used to treat HIV/AIDS. Lamivudine is phosphorylated to lamivudine triphosphate (L-TP), which is its active metabolite. Lamivudine triphosphate (L-TP) can bind and inhi...

    Drugs: Lamivudine
  7. Pathway

    Efavirenz Anti-Viral Action Pathway

    smpdb.ca/view/SMP0124983
    Drug action

    Efavirenz is a non-nucleoside reverse transcriptase inhibitor used to treat HIV infection or prevent the spread of HIV. When HIV infects a cell, the virus first binds and fuses with the cell, releasing its nucleocapsid containing its RNA...

    Drugs: Efavirenz
  8. Pathway

    Lamivudine Metabolism Pathway

    smpdb.ca/view/SMP0000649
    Drug metabolism

    Lamivudine (2'-deoxy-3'-thiacytidine, 3TC) is a pyrimidine analog reverse transcriptase enzyme inhibitor used to treat human immunodeficiency virus type I (HIV-1), HIV-2, and Hepatitis B. When metabolized to its active triphosphate form,...

    Drugs: ATP · Lamivudine · Magnesium cation · Uridine-5'-Diphosphate · N,N,N-Trimethyl-2-(phosphonooxy)ethanaminium · Pyrophosphoric acid
  9. Pathway

    Emtricitabine Action Pathway

    smpdb.ca/view/SMP0000741
    Drug action

    Emtricitabine (also known as FTC) is a nucleoside reverse transcriptase inhibitor (NRTI) for treating HIV infection by inhibiting the transcriptase reversibly. Emtricitabine is phosphorylated to form emtricitabine 5'-triphosphate so that...

    Drugs: Emtricitabine
  10. Pathway

    Rilpivirine Action Pathway

    smpdb.ca/view/SMP0000744
    Drug action

    Rilpivirine, sold as Edurant, is an antiretroviral drug that works as a non-nucleoside reverse transcriptase inhibitor (NNRTI) to treat HIV infections. NNRTI drugs work by entering the cell that HIV is present in, and binding to HIV's re...

    Drugs: Rilpivirine