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XL-888
go.drugbank.com/drugs/DB12981InvestigationalXL888 has been used in trials studying the treatment of Cancer and Melanoma.
Ketorolac
go.drugbank.com/drugs/DB00465ApprovedInvestigational[L6358][L6508][L11055][L3674][L11070] It's analgesic properties make it a useful pain management tool across many settings including postoperative pain, rheumatoid arthritis, osteoarthritis, menstrual
Mixtures: DexMoxiKetor PF, Ketorocaine L KitCategories: Cytochrome P-450 Substrates, Cytochrome P-450 CYP2C8 SubstratesAlfuzosin
go.drugbank.com/drugs/DB00346ApprovedThe prevalence of BPH is as high as 50%-60% for males in their 60's, and this prevalence increases to 80%-90% of those over 70.
Synonyms: N-[3-[(4-amino-6,7-dimethoxy-quinazolin-2-yl)- methyl-amino]propyl] tetrahydrofuran- 2-carboxamideInternational brands: Alfasin XRBupropion
go.drugbank.com/drugs/DB01156ApprovedInvestigationalBupropion (also known as the brand name product Wellbutrin®) is a norepinephrine/dopamine-reuptake inhibitor (NDRI) used most commonly for the management of Major Depressive Disorder (MDD), Seasonal Affective Disorder (SAD), and as an ai...
Categories: Cytochrome P-450 Substrates, Cytochrome P-450 CYP2B6 SubstratesProducts: Budeprion XL XL, Wellbutrin XL XLNifedipine
go.drugbank.com/drugs/DB01115ApprovedInvestigationalNifedipine, or BAY a 1040, is a first generation dihydropyridine L-type calcium channel blocker, similar to [nicardipine].
Mixtures: Adalat XL Plus, Adalat XL PlusCategories: P-glycoprotein inducers, P-glycoprotein inhibitorsFluvastatin
go.drugbank.com/drugs/DB01095ApprovedInvestigationalFluvastatin is an antilipemic agent that competitively inhibits hydroxymethylglutaryl-coenzyme A (HMG-CoA) reductase. HMG-CoA reductase catalyzes the conversion of HMG-CoA to mevalonic acid, the rate-limiting step in cholesterol biosynth...
Categories: Cytochrome P-450 CYP2B6 Inducers, Cytochrome P-450 CYP1A1 SubstratesProducts: FLUVASTATIN 1A PH 80MG RET, Lescol XLDoxazosin
go.drugbank.com/drugs/DB00590ApprovedInvestigationalDoxazosin is an alpha-1 antagonist used for the treatment of benign prostatic hypertrophy (BPH) symptoms and hypertension. Other members of this drug class include Prazosin, Terazosin, Tamsulosin, and Alfuzosin. Because of its long-lasti...
Categories: P-glycoprotein inhibitors, Cytochrome P-450 SubstratesProducts: Cardura XL, CARDURA XLTacrolimus
go.drugbank.com/drugs/DB00864ApprovedInvestigationalThis FKBP12-FK506 complex inhibits calcineurin which inhibits T-lymphocyte signal transduction and IL-2 transcription.
Categories: P-glycoprotein inducers, P-glycoprotein inhibitorsProducts: Envarsus Pa, Astagraf XLRopinirole
go.drugbank.com/drugs/DB00268ApprovedInvestigationalRopinirole, also known as ReQuip, is a non-ergoline dopamine agonist used in Parkinson's disease and restless legs syndrome [FDA label], . It is manufactured by GlaxoSmithKline Pharmaceuticals. Ropinirole was initially approved in 1997 b...
Categories: Cytochrome P-450 Substrates, Cytochrome P-450 CYP1A2 SubstratesProducts: Requip XL, PARGUIP XL 2 MG UZATILMIŞ SALIMLI TABLET, 28 ADETTopiramate
go.drugbank.com/drugs/DB00273ApprovedInvestigationalTopiramate is a anti-epileptic drug used to manage seizures and prevent migraines. It was initially approved by the FDA in 1996. In 2004, topiramate was approved for the prevention of migraine in adults. Since 2012, the extended-release ...
Categories: P-glycoprotein substrates, Cytochrome P-450 CYP3A InducersProducts: TOPIROL ® 25, TOPIROL ® 100