Search
Homeobox protein engrailed-2
go.drugbank.com/bio_entities/BE0004484TargetHumansSynonyms: Hu-En-2, Homeobox protein en-2Chemotaxis protein CheY
go.drugbank.com/bio_entities/BE0002023TargetEscherichia coli (strain K12)In its active (phosphorylated or acetylated) form, CheY exhibits enhanced binding to a switch component, FliM, at the flagellar motor which induces a change from counterclockwise to clockwise flagellar … Overexpression of CheY in association with MotA and MotB improves motility of a ycgR disruption, suggesting there is an interaction (direct or indirect) between the c-di-GMP-binding flagellar brake protein
Polypeptides: Chemotaxis protein CheYChemotaxis protein CheA
go.drugbank.com/bio_entities/BE0001431TargetThermotoga maritima (strain ATCC 43589 / MSB8 / DSM 3109 / JCM 10099)CheA is autophosphorylated; it can transfer its phosphate group to either CheB or CheY (By similarity).
Polypeptides: Chemotaxis protein CheAProtein S100-A12
go.drugbank.com/bio_entities/BE0001206TargetHumansS100A12 is a calcium-, zinc- and copper-binding protein which plays a prominent role in the regulation of inflammatory processes and immune response. Its pro-inflammatory activity involves recruitment of leukocytes, promotion of cytokine...
Synonyms: EN-RAGEMethyl-accepting chemotaxis protein II
go.drugbank.com/bio_entities/BE0001434TargetSalmonella typhimurium (strain LT2 / SGSC1412 / ATCC 700720)Receptor for the attractant L-aspartate and related amino and dicarboxylic acids. Tar mediates taxis away from the repellents cobalt and nickel. Unlike in E.coli tar, it does not mediate maltose taxis.
Synonyms: cheMCholinesterase
go.drugbank.com/bio_entities/BE0002180TargetEnzymeHumansEsterase with broad substrate specificity. Contributes to the inactivation of the neurotransmitter acetylcholine. Can degrade neurotoxic organophosphate esters
Synonyms: CHE1Aldo-keto reductase family 1 member C4
go.drugbank.com/bio_entities/BE0000438TargetCarrierEnzymeHumansCatalyzes the inactivation of 5alpha-DHT and progesterone converting them into 3alpha/beta-androstanediols and (20S)-hydroxypregn-4-en-3-one, respectively (PubMed:10998348, PubMed:11158055, PubMed:14672942
Synonyms: CHDR20-ketosteroid reductase (20-hydroxysteroid dehydrogenase)
go.drugbank.com/bio_entities/BE0009795EnzymeHumans and other mammalsCatalyzes the inactivation of 5alpha-DHT and progesterone converting them into 3alpha/beta-androstanediols and (20S)-hydroxypregn-4-en-3-one, respectively (PubMed:10998348, PubMed:24434280). … Catalyzes the reduction of progesterone to less potent progestogen (20S)-hydroxypregn-4-en-3-one likely regulating ligand availability for progesterone receptors (PubMed:10998348, PubMed:11013348, PubMed
Synonyms: CHDRFunction: 17-alpha,20-alpha-dihydroxypregn-4-en-3-one dehydrogenase [NAD(P)+] activityAldo-keto reductase family
go.drugbank.com/bio_entities/BE0009802EnzymeHumansCapable of reducing a broad range of delta-(4)-3-ketosteroids from C18 (such as, 17beta-hydroxyestr-4-en-3-one) to C27 (such as, 7alpha-hydroxycholest-4-en-3-one) … Catalyzes the inactivation of 5alpha-DHT and progesterone converting them into 3alpha/beta-androstanediols and (20S)-hydroxypregn-4-en-3-one, respectively (PubMed:10998348, PubMed:24434280).
Synonyms: CHDRFunction: 17-alpha,20-alpha-dihydroxypregn-4-en-3-one dehydrogenase [NAD(P)+] activity