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Displaying all 8 results
  1. Pathway

    Fluvastatin Action Pathway (New)

    smpdb.ca/view/SMP0124569
    Drug action

    Statins bind reversibly to the active site of HMG-CoA reductase and the subsequent structural change in the enzyme effectively disables it. … Reported side effects of fluvastatin include gastrointestinal upset (diarrhea, nausea, constipation, gas, abdominal pain), myotoxicity (myopathy, myositis, rhabdomyolysis), and hepatotoxicity.

    Drugs: Fluvastatin · Calcium · Zinc · Cholesterol
    Enzymes: Membrane-bound transcription factor site-2 protease, Membrane-bound transcription factor site-1 protease
  2. Pathway

    Pravastatin Action Pathway (New)

    smpdb.ca/view/SMP0124576
    Drug action

    Statins bind reversibly to the active site of HMG-CoA reductase and the subsequent structural change in the enzyme effectively disables it. … Reported side effects of Pravastatin include constipation, flatulence, dyspepsia (indigestion), abdominal pain, headache, and myalgia (muscle pain).

    Drugs: Pravastatin · Calcium · Zinc · Cholesterol
    Enzymes: Membrane-bound transcription factor site-2 protease, Membrane-bound transcription factor site-1 protease
  3. Pathway

    Pitavastatin Action Pathway

    smpdb.ca/view/SMP0126665
    Drug action

    Pitavastatin, also known as Livalo, is an hydroxymethylglutaryl-coenzyme A (HMG-CoA) reductase inhibitor. This drug is a lipid-lowering drug belonging to the statin class of medications. The inhibited enzyme is catalyzing the conversion ...

    Drugs: Calcium · Zinc · Cholesterol · Pitavastatin
    Enzymes: Membrane-bound transcription factor site-2 protease, Membrane-bound transcription factor site-1 protease
  4. Pathway

    Lovastatin Action Pathway (New)

    smpdb.ca/view/SMP0124570
    Drug action

    Statins bind reversibly to the active site of HMG-CoA reductase and the subsequent structural change in the enzyme effectively disables it. … Reported side effects of lovastatin include constipation, flatulence, dyspepsia (indigestion), abdominal pain, headache, and myalgia (muscle pain).

    Drugs: Lovastatin · Calcium · Zinc · Cholesterol
    Enzymes: Membrane-bound transcription factor site-2 protease, Membrane-bound transcription factor site-1 protease
  5. Pathway

    Rosuvastatin

    smpdb.ca/view/SMP0124577
    Drug action

    Statins bind reversibly to the active site of HMG-CoA reductase and the subsequent structural change in the enzyme effectively disables it. … Reported side effects of Rosuvastatin include constipation, flatulence, dyspepsia (indigestion), abdominal pain, headache, and myalgia (muscle pain).

    Drugs: Rosuvastatin · Calcium · Zinc · Cholesterol
    Enzymes: Membrane-bound transcription factor site-2 protease, Membrane-bound transcription factor site-1 protease
  6. Pathway

    Simvastatin Action Pathway (New)

    smpdb.ca/view/SMP0124578
    Drug action

    Statins bind reversibly to the active site of HMG-CoA reductase and the subsequent structural change in the enzyme effectively disables it. … Reported side effects of Simvastatin include constipation, flatulence, dyspepsia (indigestion), abdominal pain, headache, and myalgia (muscle pain).

    Drugs: Simvastatin · Calcium · Zinc · Cholesterol
    Enzymes: Membrane-bound transcription factor site-2 protease, Membrane-bound transcription factor site-1 protease
  7. Pathway

    Atorvastatin Action Pathway (New)

    smpdb.ca/view/SMP0124555
    Drug action

    Statins bind reversibly to the active site of HMG-CoA reductase and the subsequent structural change in the enzyme effectively disables it. … Reported side effects of atorvastatin include constipation, flatulence, dyspepsia (indigestion), abdominal pain, headache, and myalgia (muscle pain).

    Drugs: Calcium · Zinc · Cholesterol
    Enzymes: Membrane-bound transcription factor site-2 protease, Membrane-bound transcription factor site-1 protease
  8. Pathway

    Atorvastatin Action Pathway

    smpdb.ca/view/SMP0000131
    Drug action

    Statins bind reversibly to the active site of HMG-CoA reductase and the subsequent structural change in the enzyme effectively disables it. … Reported side effects of atorvastatin include constipation, flatulence, dyspepsia (indigestion), abdominal pain, headache, and myalgia (muscle pain).

    Drugs: Calcium · Zinc · Cholesterol
    Enzymes: Membrane-bound transcription factor site-2 protease, Membrane-bound transcription factor site-1 protease