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Filgrastim
Filgrastim is a short-acting recombinant, non-pegylated human granulocyte colony-stimulating factor (G-CSF) analog produced by recombinant DNA technology. It has an amino acid sequence identical to endogenous G-CSF, but it is non-glycosylated unlike the endogenous G-CSF and has an N-terminal methionine added in the ...
Pegfilgrastim
go.drugbank.com/drugs/DB00019ApprovedInvestigational[A29,A187607] Due to a longer half-life and slower elimination rate than filgrastim, pegfilgrastim requires less frequent dosing than filgrastim; however, pegfilgrastim has a comparable pharmacological … [A187631] Due to the relatively short circulating half-life of filgrastim, a 20 kDa PEG moiety was covalently conjugated to the N-terminus of filgrastim (at the methionine residue) to develop longer-acting
Synonyms: peg-filgrastimMotixafortide
go.drugbank.com/drugs/DB14939ApprovedInvestigationaltwo apheresis procedures, compared to ~26% of patients receiving only filgrastim. … [L48116] When administered alongside [filgrastim], another agent used to aid in stem cell collection, motixafortide enabled the collection of an adequate number of stem cells in ~92% of patients within
Ancestim
go.drugbank.com/drugs/DB09103ApprovedWithdrawnAncestim is a non-glycosylated recombinant methionyl human stem cell factor. It is a 166 amino acid protein produced by E. coli with an amino acid sequence that is identical to the natural sequence predicted from human DNA sequence analy...
Hematopoietic Subsyndrome of Acute Radiation Syndrome
go.drugbank.com/conditions/DBCOND0020289Decrease in absolute neutrophil count
go.drugbank.com/conditions/DBCOND0102577Febrile Neutropenia
go.drugbank.com/conditions/DBCOND0029915