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Displaying results 1 - 10 of 50 in total
  1. Drug

    Tamsulosin

    go.drugbank.com/drugs/DB00706
    ApprovedInvestigational

    [A178351] Tamsulosin was first approved by the FDA on April 15, 1997.[L6238] … Tamsulosin is a selective alpha-1A and alpha-1B adrenoceptor antagonist that exerts its greatest effect in the prostate and bladder, where these receptors are most common.

    Synonyms: Tamsulosine, TamsulosinSalts: Tamsulosin hydrochloride
  2. Target

    NACHT, LRR and PYD domains-containing protein 3

    go.drugbank.com/bio_entities/BE0010347
    TargetHumans

    Sensor component of the NLRP3 inflammasome, which mediates inflammasome activation in response to defects in membrane integrity, leading to secretion of inflammatory cytokines IL1B and IL18 and pyroptosis (PubMed:16407889, PubMed:1840367...

    Polypeptides: NACHT, LRR and PYD domains-containing protein 3
  3. Drug

    Dutasteride

    go.drugbank.com/drugs/DB01126
    ApprovedInvestigational

    Dutasteride was approved by the FDA in 2001 for the treatment of symptomatic benign prostatic hyperplasia (BPH) in men as monotherapy or in combination with the α-adrenergic antagonist [tamsulosin] to

    Mixtures: DUTASTERIDE E TAMSULOSINA DOC, DUTASTERIDE E TAMSULOSINA DOCCategories: tamsulosin and dutasteride
  4. Pathway

    Tamsulosin Action Pathway

    smpdb.ca/view/SMP0125129
    Drug action

    The specificity of tamsulosin focuses the effects to the target area while minimizing effects in other areas. … Tamsulosin is a blocker of alpha-1A and alpha-1D adrenoceptors but about 70% of the alpha-1 adrenoceptors in the prostate are of the alpha-1A subtype.

    Drugs: Tamsulosin · Calcium · Magnesium cation
  5. Drug

    Dexketoprofen

    go.drugbank.com/drugs/DB09214
    ApprovedInvestigationalWithdrawn

    Dexketoprofen is a non-steroidal anti-inflammatory drug. It is available in the various countries in Europe, Asia and Latin America. It has analgesic, antipyretic and anti-inflammatory properties .

    Products: FENDEX
  6. Pathway

    nAchR Smooth Muscle Contraction

    smpdb.ca/view/SMP0126643
    Physiological

    Acetylcholine released from neuromuscular neurons activates nicotinic acetylcholine receptors (nAchR) on smooth muscle membranes.

    Drugs: Calcium · Magnesium cation · Acetylcholine
  7. Target

    Neuronal Acetylcholine (nACh) Receptor Subunits

    go.drugbank.com/bio_entities/BE0009927
    TargetHumans

    Hypothalamic CHRNA3:CHRNB4 nAChR activation by nicotine leads to activation of POMC neurons and a decrease in food intake (By similarity). … Hypothalamic CHRNA3:CHRNB4 nAChR activation by nicotine leads to activation of POMC neurons and a decrease in food intake (By similarity)

    Synonyms: NACHR alpha-10, NACHR alpha-9
  8. Drug

    Pozanicline

    go.drugbank.com/drugs/DB05458
    Investigational

    In radioligand binding studies, ABT-089 has shown selectivity toward the alpha4beta2 nAChR subtype as compared to the alpha7 and alpha1beta1deltagamma nAChR subtypes.

  9. Drug

    Diphenhydramine

    go.drugbank.com/drugs/DB01075
    ApprovedInvestigational

    Diphenhydramine - perhaps known most commonly as its brand name formulation Benadryl - is a first-generation H1 receptor antihistamine that is used extensively for the treatment of seasonal allergies, insect bites and stings, and rashes ...

    Products: MORADORM NACHTR DIPH 50MG
  10. Drug

    Doxazosin

    go.drugbank.com/drugs/DB00590
    ApprovedInvestigational

    Other members of this drug class include [Prazosin], [Terazosin], [Tamsulosin], and [Alfuzosin].[A180661] Because of its long-lasting effects, doxazosin can be administered once a day.