Displaying drugs 3076 - 3100 of 11512 in total
Doxapram
A central respiratory stimulant with a brief duration of action. (From Martindale, The Extra Pharmocopoeia, 30th ed, p1225)
Approved
Vet approved
Matched Description: … A central respiratory stimulant with a brief duration of action. …
Crotalus atrox antivenin
Each year it is estimated there are 45,000 snakebites in the US and 300,000 to 400,000 bites worldwide. About 8000 of these snakebites involve venomous snake species. The majority of people bitten are males and about 50% occur in the age group of 18 to 28 .
Crotalus atrox antivenin...
Approved
Experimental
Saquinavir
Saquinavir is an HIV-1 protease inhibitor used in combination with ritonavir and other antiretrovirals for the treatment of human immunodeficiency virus-1 (HIV-1) infection. In 1995 it became the first protease inhibitor approved by the FDA, followed shortly by ritonavir in 1996, and remains in clinical use today due to a...
Approved
Investigational
Matched Description: … approved by the FDA, followed shortly by ritonavir in 1996, and remains in clinical use today due to a ... bioavailability (approximately 4%),[L3450] its current indications require the co-administration of ritonavir - a …
Etoricoxib
Etoricoxib is a new COX-2 selective inhibitor. Current therapeutic indications are: treatment of rheumatoid arthritis, osteoarthritis, ankylosing spondylitis, chronic low back pain, acute pain and gout. Like any other COX-2 selective inhibitor, Etoricoxib selectively inhibits isoform 2 of cyclo-oxigenase enzyme (COX-2) to reduce the generation of prostaglandins (PGs) from arachidonic...
Approved
Investigational
Matched Description: … Etoricoxib is a new COX-2 selective inhibitor. …
Hydrocodone
Hydrocodone is a synthetic opioid derivative of codeine. It is commonly used in combination with acetaminophen to control moderate to severe pain. Historically, hydrocodone has been used as a cough suppressant although this has largely been replaced by dextromethorphan in current cough and cold formulations. Hydrocodone's more potent metabolite, hydromorphone...
Approved
Illicit
Investigational
Matched Description: … Hydrocodone is a synthetic opioid derivative of codeine. ... Historically, hydrocodone has been used as a cough suppressant although this has largely been replaced …
Gemfibrozil
Gemfibrozil is a fibric acid agent, similar to clofibrate, used to treat Type IIb, IV, and V hyperlipidemias.[A185777,L8525] Gemfibrozil is not a first line treatment and is prescribed to patients who have not responded adequately to weight loss, diet, exercise, and other medications. Gemfibrozil was granted FDA approval on 21...
Approved
Matched Description: … [A185777,L8525] Gemfibrozil is not a first line treatment and is prescribed to patients who have not ... Gemfibrozil is a fibric acid agent, similar to [clofibrate], used to treat Type IIb, IV, and V hyperlipidemias …
Blinatumomab
Blinatumomab is a BiTE-class (bi-specific T-cell engager) constructed monoclonal antibody formed by the recombinant fusion of an anti-CD3 single-chain variable fragment (scFV) and an anti-CD19 scFV through a short peptide linker.[A254836,L44311] CD3 is an antigen expressed on the surface of T-cells, while CD19 is mostly expressed on the surface of...
Approved
Investigational
Matched Description: … [L46991,L46996]
Blinatumomab has a short half-life, requiring patients to receive a continuous infusion ... over 4-week cycles using a portable mini-pump for optimum delivery. ... Blinatumomab is a BiTE-class (bi-specific T-cell engager) constructed monoclonal antibody formed by the …
Chlorthalidone
Chlorthalidone is a thiazide-like diuretic used for the treatment of hypertension and for management of edema caused by conditions such as heart failure or renal impairment. Chlorthalidone improves blood pressure and swelling by preventing water absorption from the kidneys through inhibition of the Na+/Cl− symporter in the distal convoluted tubule...
Approved
Matched Description: … Chlorthalidone is a thiazide-like diuretic used for the treatment of hypertension and for management ... These pathways may play a role in chlorthalidone's cardiovascular risk reduction effects.[A176330] ... Chlorthalidone has been shown to have a number of pleiotropic effects that differentiate it from other …
Cefdinir
Cefdinir, also known as Omnicef, is a semi-synthetic, broad-spectrum antibiotic belonging to the third generation of the cephalosporin class. It has been proven to be effective for the treatment of common bacterial infections in the ear, sinus, throat, lungs, and skin. Cefdinir was approved by the FDA in 1997 to...
Approved
Matched Description: … Cefdinir, also known as Omnicef, is a semi-synthetic, broad-spectrum antibiotic belonging to the third ... Cefdinir was approved by the FDA in 1997 to treat a variety of mild to moderate infections and was initially …
Moxisylyte
Moxisylyte, denominated as thymoxamine in the UK, is a specific and orally active α1-adrenergic antagonist. According to the WHO, moxisylyte is approved since 1987 and in the same year, it acquired the denomination of orphan product by the FDA. This drug was developed by the Japanese company Fujirebio and also...
Approved
Investigational
Matched Description: … Moxisylyte, denominated as thymoxamine in the UK, is a specific and orally active α1-adrenergic antagonist …
Oxandrolone
A synthetic hormone with anabolic and androgenic properties.
Approved
Investigational
Matched Description: … A synthetic hormone with anabolic and androgenic properties. …
Flucytosine
A fluorinated cytosine analog that is used as an antifungal agent.
Approved
Investigational
Matched Description: … A fluorinated cytosine analog that is used as an antifungal agent. …
Ataluren
Ataluren is a novel, orally administered drug that targets nonsense mutations. Ataluren is approved for use by the European Medicines Agency to treat Duchenne Muscular Dystrophy in patients aged 5 years and older who are able to walk. More specifically, ataluren is used in the small group of patients whose...
Approved
Investigational
Matched Description: … Ataluren is a novel, orally administered drug that targets nonsense mutations. ... genetic defect (called a ‘nonsense mutation’) in the dystrophin gene. ... More specifically, ataluren is used in the small group of patients whose disease is caused by a specific …
Cerliponase alfa
Cerliponase alfa is an enzyme replacement treatment for a specific form of Batten disease. It was the first FDA-approved treatment to slow loss of walking ability (ambulation) in symptomatic pediatric patients 3 years of age and older with late infantile neuronal ceroid lipofuscinosis type 2 (CLN2), also known as tripeptidyl...
Approved
Investigational
Matched Description: … Cerliponase alfa is an enzyme replacement treatment for a specific form of Batten disease. …
Atovaquone
Atovaquone is a hydroxynaphthoquinone, or an analog of ubiquinone, that has antimicrobial and antipneumocystis activity. It is being used in antimalarial protocols.
Approved
Matched Description: … Atovaquone is a hydroxynaphthoquinone, or an analog of ubiquinone, that has antimicrobial and antipneumocystis …
Anakinra
Anakinra is a recombinant human interleukin-1 (IL-1) receptor antagonist (IL-1Ra) composed of 153 amino acid residues. Unlike native human IL-1Ra, anakinra has an additional methionine residue at the amino terminus. This drug binds to the IL-1 receptor, competing with and inhibiting the activity of IL-1 alpha and beta. Anakinra is...
Approved
Investigational
Matched Description: … Anakinra is a recombinant human interleukin-1 (IL-1) receptor antagonist (IL-1Ra) composed of 153 amino ... A few studies have evaluated the use of anakinra for the treatment of coronavirus disease 2019 (COVID …
Abarelix
Synthetic decapeptide antagonist to gonadotropin releasing hormone (GnRH). It is marketed by Praecis Pharmaceuticals as Plenaxis. Praecis announced in June 2006 that it was voluntarily withdrawing the drug from the market.
Approved
Investigational
Withdrawn
Avanafil
Avanafil is a phosphodiesterase-5 (PDE5) inhibitor used in the treatment of erectile dysfunction. In comparison with other drugs of the same class, it shows greater selectivity for PDE5 over PDE6 than both sildenafil and vardenafil but less selectivity than tadalafil, suggesting a relatively lower risk of visual disturbances associated with...
Approved
Matched Description: … Avanafil is a phosphodiesterase-5 (PDE5) inhibitor used in the treatment of erectile dysfunction. ... over PDE6 than both [sildenafil] and [vardenafil] but less selectivity than [tadalafil], suggesting a …
Atenolol
Atenolol is a cardioselective beta-blocker used in a variety of cardiovascular conditions.
Sir James Black, a Scottish pharmacologist, pioneered the use of beta-blockers for the management of angina pectoris in 1958 for which he received the Nobel Prize. Beta-blockers quickly became popular in clinical use and where subsequently investigated for...
Approved
Matched Description: … Atenolol is a cardioselective beta-blocker used in a variety of cardiovascular conditions. ... shows a risk ratio of 0.88 for cardiovascular disease risk and a risk ratio of 0.99 for mortality. ... Sir James Black, a Scottish pharmacologist, pioneered the use of beta-blockers for the management of …
Tauroursodeoxycholic acid
Tauroursodeoxycholic acid, also known as ursodoxicoltaurine, is a highly hydrophilic tertiary bile acid that is produced in humans at a low concentration. It is a taurine conjugate of ursodeoxycholic acid with comparable therapeutic efficacy and safety, but a much higher hydrophilicity. Normally, hydrophilic bile acids regulates hydrophobic bile acids and...
Approved
Investigational
Matched Description: … and safety,[A249070] but a much higher hydrophilicity. ... [A249070] that is produced in humans at a low concentration. ... Tauroursodeoxycholic acid, also known as ursodoxicoltaurine, is a highly hydrophilic tertiary bile acid …
Thiotepa
N,N'N'-triethylenethiophosphoramide (ThioTEPA) is a cancer chemotherapeutic member of the alkylating agent group, now in use for over 50 years. It is a stable derivative of N,N',N''- triethylenephosphoramide (TEPA). It is mostly used to treat breast cancer, ovarian cancer and bladder cancer. It is also used as conditioning for Bone marrow...
Approved
Investigational
Matched Description: … It is a stable derivative of N,N',N''- triethylenephosphoramide (TEPA). ... N,N'N'-triethylenethiophosphoramide (ThioTEPA) is a cancer chemotherapeutic member of the alkylating …
Matched Categories: … Cytochrome P-450 CYP3A4 Substrates with a Narrow Therapeutic Index …
Matched Categories: … Cytochrome P-450 CYP3A4 Substrates with a Narrow Therapeutic Index …
gamma-Hydroxybutyric acid
Gamma hydroxybutyric acid, commonly abbreviated GHB, is a therapeutic drug which is illegal in multiple countries. It is currently regulated in the US and sold by Jazz Pharmaceuticals under the name Xyrem. However, it is important to note that GHB is a designated Orphan drug (in 1985). Today Xyrem is...
Approved
Illicit
Investigational
Matched Description: … Today Xyrem is a Schedule III drug; however GHB remains a Schedule I drug and the illicit use of Xyrem ... However, it is important to note that GHB is a designated Orphan drug (in 1985). ... Gamma hydroxybutyric acid, commonly abbreviated GHB, is a therapeutic drug which is illegal in multiple …
Simoctocog alfa
Simoctocog alfa is a recombinant B-domain deleted (BDD) rFVIII produced in genetically modified human embryonic kidney (HEK) 293F cells. The harvested product is concentrated and purified by a series of chromatography steps. It is an antihemorrhagic agent used as a replacement therapy in individuals with Haemophilia A who lack the...
Approved
Matched Description: … It is an antihemorrhagic agent used as a replacement therapy in individuals with Haemophilia A who lack ... The harvested product is concentrated and purified by a series of chromatography steps. ... Simoctocog alfa is a recombinant B-domain deleted (BDD) rFVIII produced in genetically modified human …
Entacapone
Entacapone is a selective, reversible catechol-O-methyl transferase (COMT) inhibitor for the treatment of Parkinson's disease. It is a member of the class of nitrocatechols. When administered concomittantly with levodopa and a decarboxylase inhibitor (e.g., carbidopa), increased and more sustained plasma levodopa concentrations are reached as compared to the administration of...
Approved
Investigational
Matched Description: … It is a member of the class of nitrocatechols. ... Entacapone is a selective, reversible catechol-O-methyl transferase (COMT) inhibitor for the treatment ... When administered concomittantly with levodopa and a decarboxylase inhibitor (e.g., carbidopa), increased …
Displaying drugs 3076 - 3100 of 11512 in total