Displaying drugs 3651 - 3675 of 11866 in total
Decitabine
Myelodysplastic syndromes (MDS) are a heterogeneous group of hematopoietic neoplasms with variable underlying etiology and presentation, including neutropenia and thrombocytopenia. Further mutations leading to increased proliferation of cancerous cells can eventually lead to secondary acute myeloid leukemia, which has a poor prognosis.[A215082, A215092] Among treatment options, nucleoside analogues such as...
Approved
Investigational
Matched Description: … Myelodysplastic syndromes (MDS) are a heterogeneous group of hematopoietic neoplasms with variable underlying ... proliferation of cancerous cells can eventually lead to secondary acute myeloid leukemia, which has a …
Mecasermin
Mecasermin contains recombinant-DNA-engineered human insulin-like growth factor-1 (rhIGF-1)[FDA Label]. IGF-1 consists of 70 amino acids in a single chain with three intramolecular disulfide bridges and a molecular weight of 7649 daltons. The amino acid sequence of the product is identical to that of endogenous human IGF-1. The rhIGF-1 protein is...
Approved
Investigational
Matched Description: … IGF-1 consists of 70 amino acids in a single chain with three intramolecular disulfide bridges and a …
Daratumumab
Daratumumab is an immunoglobulin G1 kappa monoclonal antibody developed by Janssen and Genmab. It was first described in the literature in 2010 as a monoclonal antibody that targets CD38+ multiple myeloma cells; the first of its kind. Daratumumab was granted FDA approval on 16 November 2015. It is approved for...
Approved
Matched Description: … [A7935] It was first described in the literature in 2010 as a monoclonal antibody that targets CD38+ …
Fraxinus americana pollen
Fraxinus americana pollen is the pollen of the Fraxinus americana plant. Fraxinus americana pollen is mainly used in allergenic testing.
Approved
Artemisia vulgaris pollen
Artemisia vulgaris pollen is the pollen of the Artemisia vulgaris plant. Artemisia vulgaris pollen is mainly used in allergenic testing.
Approved
Ambrosia bidentata pollen
Ambrosia bidentata pollen is the pollen of the Ambrosia bidentata plant. Ambrosia bidentata pollen is mainly used in allergenic testing.
Approved
Ferrous asparto glycinate
Ferrous asparto glycinate is an iron-amino acid chelate. It is available as a dietary supplement used in the treatment of iron deficiency and iron deficiency anemia.
Approved
Matched Description: … It is available as a dietary supplement used in the treatment of iron deficiency and iron deficiency …
Etafedrine
Etafedrine (INN) or ethylephedrine is a long-acting bronchodilator and has been an ingredient combined with other drugs in the brand names Nethaprin and Dalmacol . It was previously available as both the free base and as the hydrochloride salt manufactured by Sanofi-Aventis (now Sanofi) has been discontinued .
Ethylephedrine is...
Approved
Matched Description: … Etafedrine (INN) or ethylephedrine is a long-acting bronchodilator and has been an ingredient combined ... The hydrochloride is be prepared by passing hydrogen chloride through a solution of ethylephedrine in …
Betazole
A histamine H2 agonist used clinically to test gastric secretory function.
Approved
Matched Description: … A histamine H2 agonist used clinically to test gastric secretory function. …
Futibatinib
Futibatinib is an inhibitor of Fibroblast Growth Factor receptor (FGFR), which comprises a group of receptor tyrosine kinases that play a key role in cell proliferation, differentiation, migration, and survival. FGFR was investigated in oncology as a therapeutic target, as FGFR genomic aberrations and dysregulated FGFR signalling pathways are observed...
Approved
Investigational
Matched Description: … Futibatinib is an inhibitor of Fibroblast Growth Factor receptor (FGFR), which comprises a group of receptor ... tyrosine kinases that play a key role in cell proliferation, differentiation, migration, and survival ... FGFR was investigated in oncology as a therapeutic target, as FGFR genomic aberrations and dysregulated …
Sufentanil
Sufentanil is an opioid analgesic that is used as an adjunct in anesthesia, in balanced anesthesia, and as a primary anesthetic agent. It is administered by the intravenous, epidural and sublingual routes.
Also known as Dsuvia, the sublingual form is used for the management of acute pain in adults that...
Approved
Investigational
Matched Description: … Sufentanil is an opioid analgesic that is used as an adjunct in anesthesia, in balanced anesthesia, and as a ... This route of administration is intended to be a simple, effective, non-invasive analgesic option to …
Tenapanor
Tenapanor is a novel, small molecule medication approved in September 2019 for the treatment of constipation-predominant irritable bowel-syndrome (IBS-C). It was first designed and synthesized in 2012. As an inhibitor of the sodium/hydrogen exchanger isoform 3 (NHE3) transporter, it is the first and currently only medication within its class[A185489,A185492,A185495] and...
Approved
Investigational
Matched Description: … first and currently only medication within its class[A185489,A185492,A185495] and therefore exists as a ... Tenapanor is a novel, small molecule medication approved in September 2019 for the treatment of constipation-predominant …
Pimavanserin
Pimavanserin is an atypical antipsychotic indicated for the treatment of psychiatric disorders. Although the exact mechanism of action is unknown, it is thought that pimavanserin interacts with the serotonin receptors, particularly the 5-HT2A and HT2C receptors. Unlike other atypical antipsychotics, pimavanserin lacks inherent dopaminergic activity. In fact, pimavanserin is the...
Approved
Investigational
Matched Description: … [L48241,A232573] Pimavanserin was also under review as a potential treatment for dementia-related psychosis ... hallucinations and delusions associated with Parkinson's disease psychosis thanks to favorable results from a …
Pegvaliase
Pegvaliase is a recombinant phenylalanine ammonia lyase (PAL) enzyme derived from Anabaena variabilis that converts phenylalanine to ammonia and trans-cinnamic acid . Both the U.S. Food and Drug Administration and European Medicines Agency approved pegvaliase-pqpz in May 2018 for the treatment of adult patients with phenylketonuria (PKU). Phenylketonuria is a...
Approved
Investigational
Matched Description: … The presence of a PEG moiety in pegvaliase-pqpz allows a reduced immune response and improved pharmacodynamic ... Pegvaliase is a recombinant phenylalanine ammonia lyase (PAL) enzyme derived from _Anabaena variabilis ... Phenylketonuria is a rare autosomal recessive disorder that is characterized by deficiency of the enzyme …
Sotorasib
Sotorasib, also known as AMG-510, is an acrylamide-derived KRAS inhibitor developed by Amgen.[A187547,A187556] It is indicated in the treatment of adult patients with KRAS G12C mutant non-small cell lung cancer. This mutation makes up >50% of all KRAS mutations. Mutant KRAS discovered in 1982 but was not considered a druggable...
Approved
Investigational
Matched Description: … [A187550] Mutant KRAS discovered in 1982 but was not considered a druggable target until the mid-2010s …
Panitumumab
Panitumumab (ABX-EGF) is a recombinant human IgG2 monoclonal antibody that binds specifically to the human epidermal growth factor receptor (EGFR). This drug is an antineoplastic agent.
Panitumumab was granted FDA approval on 27 September 2006.
Approved
Investigational
Matched Description: … Panitumumab (ABX-EGF) is a recombinant human IgG2 monoclonal antibody that binds specifically to the …
Amaranthus spinosus pollen
Amaranthus spinosus pollen is the pollen of the Amaranthus spinosus plant. Amaranthus spinosus pollen is mainly used in allergenic testing.
Approved
Umbralisib
Marginal zone lymphoma is a rare, slowly progressing type of non-Hodgkin lymphoma initially treated with rituximab (an anti-CD20 drug), either alone or in combination with chemotherapy. Unfortunately, many patients experience a relapse or develop resistance to these drugs. Treatment options then become limited, and alternate treatments for the lymphoma are...
Approved
Investigational
Withdrawn
Matched Description: … Unfortunately, many patients experience a relapse or develop resistance to these drugs. ... Marginal zone lymphoma is a rare, slowly progressing type of non-Hodgkin lymphoma initially treated with ... On February 5, 2021, the Food and Drug Administration granted accelerated approval to umbralisib, a …
Triamterene
Triamterene (2,4,7-triamino-6-phenylpteridine) is a potassium-sparing diuretic that is used in the management of hypertension. It works by promoting the excretion of sodium ions and water while decreasing the potassium excretion in the distal part of the nephron in the kidneys by working on the lumenal side. Since it acts on...
Approved
Matched Description: … Triamterene is a weak antagonist of folic acid, and a photosensitizing drug. ... Triamterene (2,4,7-triamino-6-phenylpteridine) is a potassium-sparing diuretic that is used in the management ... [A177985] Since it acts on the distal nephron where only a small fraction of sodium ion reabsorption …
Populus tremuloides pollen
Populus tremuloides pollen is the pollen of the Populus tremuloides plant. Populus tremuloides pollen is mainly used in allergenic testing.
Approved
Famotidine
Famotidine is a competitive histamine-2 (H2) receptor antagonist that works to inhibit gastric acid secretion. It is commonly used in gastrointestinal conditions related to acid secretion, such as gastric ulcers and gastroesophageal reflux disease (GERD), in adults and children. Compared to other H2 receptor antagonists, famotidine displays high selectivity towards...
Approved
Matched Description: … Famotidine is a competitive histamine-2 (H2) receptor antagonist that works to inhibit gastric ... H2 receptor antagonists, famotidine displays high selectivity towards this receptor; in a ... inhibiting gastric acid secretion than [cimetidine] and eight times more potent than [ranitidine] on a …
Practolol
A beta-adrenergic antagonist that has been used in the emergency treatment of cardiac arrhythmias.
Approved
Matched Description: … A beta-adrenergic antagonist that has been used in the emergency treatment of cardiac arrhythmias. …
Tarlatamab
Tarlatamab is a first-in-class T-cell engager used to treat extensive-stage small cell lung cancer. It is a bispecific monoclonal antibody that targets CD3 expressed on the surface of T-cells and delta-like ligand 3 (DLL3), an inhibitory ligand that suppresses Notch signaling and is highly expressed across various SCLC disease stages...
Approved
Investigational
Matched Description: … Tarlatamab is a first-in-class T-cell engager used to treat extensive-stage small cell lung cancer. ... [L50748] It is a bispecific monoclonal antibody that targets CD3 expressed on the surface of T-cells …
Gemifloxacin
Gemifloxacin is a quinolone antibacterial agent with a broad-spectrum activity that is used in the treatment of acute bacterial exacerbation of chronic bronchitis and mild-to-moderate pneumonia. It is available in oral formulations. Gemifloxacin acts by inhibiting DNA synthesis through the inhibition of both DNA gyrase and topoisomerase IV, which are...
Approved
Investigational
Matched Description: … Gemifloxacin is a quinolone antibacterial agent with a broad-spectrum activity that is used in the treatment …
Displaying drugs 3651 - 3675 of 11866 in total