Displaying drugs 376 - 400 of 450 in total
BNC105
Investigational
Matched Iupac: … {[6-methoxy-2-methyl-3-(3,4,5-trimethoxybenzoyl)-1-benzofuran-7-yl]oxy}phosphonic acid …
Matched Categories: … Methyl Ethers …
Matched Categories: … Methyl Ethers …
Phosphocreatine
Phosphocreatine - or creatine phosphate - is the phosphorylated form of creatine. It is primarily found endogenously in the skeletal muscles of vertebrates where it serves a critical role as a rapidly acting energy buffer for muscle cell actions like contractions via its ability to regenerate adenosine triphosphate (ATP) from...
Nutraceutical
Matched Iupac: … 2-(N-methyl-N'-phosphonocarbamimidamido)acetic acid …
Matched Description: … Phosphocreatine - or creatine phosphate - is the phosphorylated form of creatine. …
Matched Description: … Phosphocreatine - or creatine phosphate - is the phosphorylated form of creatine. …
Apadenoson
Apadenoson is a selective A2a adenosine receptor agonist designed for use as a pharmacologic stress agent in cardiac perfusion imaging studies. It is developed by Bristol-Myers Squibb and is in phase II of clinical trials.
Investigational
Matched Iupac: … methyl (1r,4r)-4-(3-{6-amino-9-[(2R,3R,4S,5S)-5-(ethylcarbamoyl)-3,4-dihydroxyoxolan-2-yl]-9H-purin-2 …
Phencyclidine
A hallucinogen formerly used as a veterinary anesthetic, and briefly as a general anesthetic for humans. Phencyclidine is similar to ketamine in structure and in many of its effects. Like ketamine, it can produce a dissociative state. It exerts its pharmacological action through inhibition of NMDA receptors (receptors, N-methyl-D-aspartate). As...
Illicit
Matched Description: … It exerts its pharmacological action through inhibition of NMDA receptors (receptors, N-methyl-D-aspartate …
Cenisertib
Cenisertib is an aurora kinase inhibitor.
Investigational
Matched Iupac: … (1S,2S,3R,4R)-3-[(5-fluoro-2-{[3-methyl-4-(4-methylpiperazin-1-yl)phenyl]amino}pyrimidin-4-yl)amino]bicyclo …
BMS-184476
BMS-184476 has been used in trials studying the treatment of Unspecified Adult Solid Tumor, Protocol Specific.
Investigational
Matched Description: … BMS-184476 has been used in trials studying the treatment of Unspecified Adult Solid Tumor, Protocol …
2-chloroethyl-3-sarcosinamide-1-nitrosourea
2-chloroethyl-3-sarcosinamide-1-nitrosourea has been used in trials studying the treatment of Colorectal Cancer, Brain and Central Nervous System Tumors, and Unspecified Adult Solid Tumor, Protocol Specific.
Investigational
Matched Iupac: … 2-{[N-(2-chloroethyl)-N'-oxohydrazinecarbonyl](methyl)amino}acetamide …
Matched Description: … in trials studying the treatment of Colorectal Cancer, Brain and Central Nervous System Tumors, and Unspecified …
Matched Description: … in trials studying the treatment of Colorectal Cancer, Brain and Central Nervous System Tumors, and Unspecified …
Altropane
Boston Life Sciences (BLS) is developing Altropane as a potential radio-imaging agent to be used with single photon emission tomography (SPECT), for the early diagnosis of Parkinson's disease (PD) and attention deficit hyperactivity disorder (ADHD).
Investigational
Matched Iupac: … methyl (1R,2S,3S,5S)-3-(4-fluorophenyl)-8-[(2E)-3-iodoprop-2-en-1-yl]-8-azabicyclo[3.2.1]octane-2-carboxylate …
Carbendazim
Carbendazim has been used in trials studying the treatment of Lymphoma and Unspecified Adult Solid Tumor, Protocol Specific.
Investigational
Matched Iupac: … methyl N-(1H-1,3-benzodiazol-2-yl)carbamate …
Matched Description: … Carbendazim has been used in trials studying the treatment of Lymphoma and Unspecified Adult Solid Tumor …
Matched Description: … Carbendazim has been used in trials studying the treatment of Lymphoma and Unspecified Adult Solid Tumor …
Soblidotin
Soblidotin has been used in trials studying the treatment of Sarcoma, Lung Cancer, and Unspecified Adult Solid Tumor, Protocol Specific.
Investigational
Matched Iupac: … -[(2S)-2-(dimethylamino)-3-methylbutanamido]-N-[(3R,4S,5S)-3-methoxy-1-[(2S)-2-[(1R,2R)-1-methoxy-2-methyl ... -2-[(2-phenylethyl)carbamoyl]ethyl]pyrrolidin-1-yl]-5-methyl-1-oxoheptan-4-yl]-N,3-dimethylbutanamide …
Matched Description: … Soblidotin has been used in trials studying the treatment of Sarcoma, Lung Cancer, and Unspecified Adult …
Matched Description: … Soblidotin has been used in trials studying the treatment of Sarcoma, Lung Cancer, and Unspecified Adult …
CNS-5161
CNS 5161 is a blocker of the NMDA ion channel and has completed Phase IIa proof of concept clinical trials as a novel compound for the treatment of neuropathic pain.
Investigational
Matched Iupac: … (E)-N''-[2-chloro-5-(methylsulfanyl)phenyl]-N-methyl-N-[3-(methylsulfanyl)phenyl]guanidine …
Intoplicine
Intoplicine has been used in trials studying the treatment of Unspecified Adult Solid Tumor, Protocol Specific.
Investigational
Matched Iupac: … 16-{[3-(dimethylamino)propyl]amino}-13-methyl-11,15-diazatetracyclo[8.7.0.0^{2,7}.0^{12,17}]heptadeca …
Matched Description: … Intoplicine has been used in trials studying the treatment of Unspecified Adult Solid Tumor, Protocol …
Matched Description: … Intoplicine has been used in trials studying the treatment of Unspecified Adult Solid Tumor, Protocol …
Eucalyptol
Eucalyptol is naturally produced cyclic ether and monoterpenoid. Eucalyptol is an ingredient in many brands of mouthwash and cough suppressant. It controls airway mucus hypersecretion and asthma via anti-inflammatory cytokine inhibition. Eucalyptol is an effective treatment for nonpurulent rhinosinusitis. Eucalyptol reduces inflammation and pain when applied topically. It kills leukaemia...
Experimental
Nutraceutical
Matched Mixtures name: … Eucalyptol, menthol, methyl salicylate, thymol ... Eucalyptol, Menthol, Methyl Salicylate, Thymol ... Eucalyptol, Menthol, Methyl Salicylate, Thymol …
Bizelesin
Bizelesin has been used in trials studying the treatment of Unspecified Adult Solid Tumor, Protocol Specific.
Investigational
Matched Iupac: … 1,3-bis({2-[(1S)-1-(chloromethyl)-5-hydroxy-8-methyl-1H,2H,3H,6H-pyrrolo[3,2-e]indole-3-carbonyl]-1H-indol …
Matched Description: … Bizelesin has been used in trials studying the treatment of Unspecified Adult Solid Tumor, Protocol Specific …
Matched Description: … Bizelesin has been used in trials studying the treatment of Unspecified Adult Solid Tumor, Protocol Specific …
Timcodar
Timcodar has been used in trials studying the treatment of Unspecified Adult Solid Tumor, Protocol Specific.
Investigational
Matched Iupac: … (2S)-N-benzyl-N-[1,5-bis(pyridin-4-yl)pentan-3-yl]-3-(4-chlorophenyl)-2-[N-methyl-2-oxo-2-(3,4,5-trimethoxyphenyl …
Matched Description: … Timcodar has been used in trials studying the treatment of Unspecified Adult Solid Tumor, Protocol Specific …
Matched Description: … Timcodar has been used in trials studying the treatment of Unspecified Adult Solid Tumor, Protocol Specific …
Molnupiravir
Molnupiravir (EIDD-2801, MK-4482) is the isopropylester prodrug of N4-hydroxycytidine.[A193014,A193026] With improved oral bioavailability in non-human primates, it is hydrolyzed in vivo, and distributes into tissues where it becomes the active 5’-triphosphate form. The active drug incorporates into the genome of RNA viruses, leading to an accumulation of mutations known as...
Investigational
Matched Iupac: … 3S,4R,5R)-3,4-dihydroxy-5-[(4Z)-4-(hydroxyimino)-2-oxo-1,2,3,4-tetrahydropyrimidin-1-yl]oxolan-2-yl]methyl …
Matched Description: … it is hydrolyzed _in vivo_, and distributes into tissues where it becomes the active 5’-triphosphate form …
Matched Description: … it is hydrolyzed _in vivo_, and distributes into tissues where it becomes the active 5’-triphosphate form …
Z-Val-Ala-Asp fluoromethyl ketone
Non-methylated, competitive, and irreversible inhibitor of caspase 1, as well as other caspases,1 which can be used directly with purified enzymes. It does not require an esterase to hydrolyze the O-methyl ester like the cell-permeable form, Z-Val-Ala-Asp(O-Me) fluoromethyl ketone.
Experimental
Matched Description: … It does not require an esterase to hydrolyze the O-methyl ester like the cell-permeable form, Z-Val-Ala-Asp …
PX-12
PX-12 (1-methylpropyl 2-imidazolyl disulfide) is a small-molecule inhibitor of Trx-1 (thioredoxin-1), stimulates apoptosis, down-regulates HIF-1α and vascular endothelial growth factor (VEGF) and inhibits tumor growth in animal models. Since high levels of Trx-1 have been associated with colorectal, gastric and lung cancers, PX-12 is indicated as a potential cancer treatment...
Investigational
Nonivamide
Nonivamide is found in herbs and spices. It is an alkaloid from the Capsicum species. The structures of DB06774 and nonivamide differ only slightly with respect to the fatty acid moiety of the side chain (8-methyl nonenoic acid versus nonanoic acid) .
Nonivamide is a flavoring ingredient. Nonivamide is an...
Investigational
Matched Iupac: … N-[(4-hydroxy-3-methoxyphenyl)methyl]nonanamide …
Matched Description: … DB06774] and nonivamide differ only slightly with respect to the fatty acid moiety of the side chain (8-methyl ... It is naturally found in chili peppers but manufactured to produce a synthetic form for various pharmacologic …
Matched Description: … DB06774] and nonivamide differ only slightly with respect to the fatty acid moiety of the side chain (8-methyl ... It is naturally found in chili peppers but manufactured to produce a synthetic form for various pharmacologic …
4'-Methylene-5,8,10-trideazaaminopterin
CH-1504 is a an antirheumatic agent that has been shown in vitro to be a nonpolyglutamylatable and nonhydroxylatable antifolate that is more efficiently taken up into cells by the reduced folate carrier (RFC) system than is Methotrexate. It has been investigated for the treatment of Rheumatoid Arthritis (phase II).
Investigational
SNS-032
Investigational
Matched Iupac: … N-(5-{[(5-tert-butyl-1,3-oxazol-2-yl)methyl]sulfanyl}-1,3-thiazol-2-yl)piperidine-4-carboxamide …
RU84687
RU84687 is a subnanomolar and Src SH2 selective binder.
Experimental
Matched Iupac: … {4-[(2S)-2-{[(3S)-1-({[1,1'-biphenyl]-4-yl}methyl)-2-oxoazepan-3-yl]carbamoyl}-2-acetamidoethyl]-2-formylphenoxy …
2'-C-methylcytidine
A nucleoside analog with anti-hepatitis C virus (HCV) activity. Upon phosphorylation into its 5-triphosphate form, this metabolite inhibits viral RNA chain elongation and viral RNA-dependent RNA polymerase activity. This blocks viral production of HCV RNA and thus viral replication.
Experimental
Matched Description: … Upon phosphorylation into its 5-triphosphate form, this metabolite inhibits viral RNA chain elongation …
RU82197
Experimental
Matched Iupac: … 4-[(2S)-2-{[(3S)-1-({[1,1'-biphenyl]-4-yl}methyl)-2-oxoazepan-3-yl]carbamoyl}-2-acetamidoethyl]-2-formylbenzoic …
Onalespib
Investigational
Matched Iupac: … 4-{5-[(4-methylpiperazin-1-yl)methyl]-2,3-dihydro-1H-isoindole-2-carbonyl}-6-(propan-2-yl)benzene-1,3 …
Displaying drugs 376 - 400 of 450 in total