Displaying drugs 2176 - 2200 of 15156 in total
Quinupristin
Quinupristin/dalfopristin is a combination of two antibiotics used to treat infections by staphylococci and by vancomycin-resistant Enterococcus faecium. Dalfopristin inhibits the early phase of protein synthesis in the bacterial ribosome and quinupristin inhibits the late phase of protein synthesis. The combination of the two components acts synergistically and is more...
Approved
Matched Iupac: … N-[(3S,6S,12R,15S,16R,19S,22S,25R)-25-{[(3S)-1-azabicyclo[2.2.2]octan-3-ylsulfanyl]methyl}-3-{[4-(dimethylamino ... )phenyl]methyl}-12-ethyl-4,16-dimethyl-2,5,11,14,18,21,24-heptaoxo-19-phenyl-17-oxa-1,4,10,13,20-pentaazatricyclo …
Matched Description: … Quinupristin/dalfopristin is a combination of two antibiotics used to treat infections by staphylococci and ... Dalfopristin inhibits the early phase of protein synthesis in the bacterial ribosome and quinupristin ... The combination of the two components acts synergistically and is more effective in vitro than each component …
Matched Categories: … Amino Acids, Peptides, and Proteins …
Matched Description: … Quinupristin/dalfopristin is a combination of two antibiotics used to treat infections by staphylococci and ... Dalfopristin inhibits the early phase of protein synthesis in the bacterial ribosome and quinupristin ... The combination of the two components acts synergistically and is more effective in vitro than each component …
Matched Categories: … Amino Acids, Peptides, and Proteins …
Somatrem
Despite the ability of almost all contemporary recombinant growth hormones to cause definite and demonstrable increases in growth rate in patients who are administered the drug, the use of these agents continues to be mired in persistent bioethical debate . Such discussion revolves around whether patients' natural disposition of short...
Approved
Investigational
Withdrawn
Matched Description: … Despite the ability of almost all contemporary recombinant growth hormones to cause definite and demonstrable …
Matched Categories: … Pituitary and Hypothalamic Hormones and Analogues ... Sex Hormones and Insulins ... Amino Acids, Peptides, and Proteins ... Somatropin and Somatropin Agonists ... Anterior Pituitary Lobe Hormones and Analogues …
Matched Categories: … Pituitary and Hypothalamic Hormones and Analogues ... Sex Hormones and Insulins ... Amino Acids, Peptides, and Proteins ... Somatropin and Somatropin Agonists ... Anterior Pituitary Lobe Hormones and Analogues …
Influenza A virus A/Uruguay/716/2007(H3N2) antigen (formaldehyde inactivated)
A seasonally-specific component of the influenza vaccine. The influenza vaccine, also known as the "flu shot", is a vaccine that protects against infection from the influenza viruses. Vaccines provide protection from influenza by exposing the immune system to the virus (or parts of the virus) which stimulates an immunological defence...
Approved
Matched Description: … Upon re-exposure to infectious influenza virus, the immune system is prepared to identify and destroy ... Inactivated vaccines contain a virus particle that has been grown in media and then subsequently killed ... There are two basic types of vaccines available: inactivated influenza vaccine (IIV) and live attenuated …
Influenza A virus A/Brisbane/59/2007 (H1N1) antigen (formaldehyde inactivated)
A seasonally-specific component of the influenza vaccine. The influenza vaccine, also known as the "flu shot", is a vaccine that protects against infection from the influenza viruses. Vaccines provide protection from influenza by exposing the immune system to the virus (or parts of the virus) which stimulates an immunological defence...
Approved
Matched Description: … Upon re-exposure to infectious influenza virus, the immune system is prepared to identify and destroy ... Inactivated vaccines contain a virus particle that has been grown in media and then subsequently killed ... There are two basic types of vaccines available: inactivated influenza vaccine (IIV) and live attenuated …
Filgotinib
Rheumatoid arthritis (RA) is a chronic, autoimmune, systemic, and inflammatory disease that causes synovial joint symptoms and can limit range of motion in severe cases.[A221451,A221456] The disease is associated with extra-articular manifestations, progressive disability, and comorbidities including cardiovascular disease and mental disorders. 50-70% of patients with RA are unable to...
Approved
Investigational
Matched Iupac: … N-(5-{4-[(1,1-dioxo-1lambda6-thiomorpholin-4-yl)methyl]phenyl}-[1,2,4]triazolo[1,5-a]pyridin-2-yl)cyclopropanecarboxamide …
Matched Description: … [A189165] JAK2 and JAK3 play important roles in both immune and hematologic functions; therefore, selectivity ... joint symptoms and can limit range of motion in severe cases. ... comorbidities including cardiovascular disease and mental disorders. …
Matched Categories: … Antineoplastic and Immunomodulating Agents …
Matched Description: … [A189165] JAK2 and JAK3 play important roles in both immune and hematologic functions; therefore, selectivity ... joint symptoms and can limit range of motion in severe cases. ... comorbidities including cardiovascular disease and mental disorders. …
Matched Categories: … Antineoplastic and Immunomodulating Agents …
Oliceridine
Severe acute pain occurs through nociceptive signalling involving both ascending and descending spinal pathways, in which nerve conductance is mediated in part by the action of opioid receptors.[A218041, A218046] Opioid receptors are seven-transmembrane G-protein-coupled receptors (GPCRs), of which the μ-opioid receptor subtype is predominantly targeted by and is responsible for...
Approved
Investigational
Matched Iupac: … [(3-methoxythiophen-2-yl)methyl]({2-[(9R)-9-(pyridin-2-yl)-6-oxaspiro[4.5]decan-9-yl]ethyl})amine …
Matched Description: … Severe acute pain occurs through nociceptive signalling involving both ascending and descending spinal ... beneficial analgesic effects of opioids are coupled with severe adverse effects such as constipation and ... G-protein-coupled receptors (GPCRs), of which the μ-opioid receptor subtype is predominantly targeted by and …
Matched Description: … Severe acute pain occurs through nociceptive signalling involving both ascending and descending spinal ... beneficial analgesic effects of opioids are coupled with severe adverse effects such as constipation and ... G-protein-coupled receptors (GPCRs), of which the μ-opioid receptor subtype is predominantly targeted by and …
Rolapitant
Rolapitant is a potent, highly selective, long-acting Neurokinin-1 (NK-1) receptor antagonist approved for the prevention of delayed chemotherapy-induced nausea and vomiting (CINV) in adults. Delayed-phase CINV typically occurs >24 hours after chemotherapy treatment and is principally mediated by Neurokinin-1 and its ligand Substance P, which is released in the gut...
Approved
Investigational
Matched Iupac: … (5S,8S)-8-{[(1R)-1-[3,5-bis(trifluoromethyl)phenyl]ethoxy]methyl}-8-phenyl-1,7-diazaspiro[4.5]decan-2 …
Matched Description: … Delayed-phase CINV typically occurs >24 hours after chemotherapy treatment and is principally mediated ... Neurokinin-1 (NK-1) receptor antagonist approved for the prevention of delayed chemotherapy-induced nausea and ... By blocking Substance P from interacting with NK-1 receptors in the gut and the central nervous system …
Matched Categories: … Antiemetics and Antinauseants ... Alimentary Tract and Metabolism …
Matched Description: … Delayed-phase CINV typically occurs >24 hours after chemotherapy treatment and is principally mediated ... Neurokinin-1 (NK-1) receptor antagonist approved for the prevention of delayed chemotherapy-induced nausea and ... By blocking Substance P from interacting with NK-1 receptors in the gut and the central nervous system …
Matched Categories: … Antiemetics and Antinauseants ... Alimentary Tract and Metabolism …
Insulin detemir
Insulin detemir is a long-acting form of insulin used for the treatment of hyperglycemia caused by Type 1 and Type 2 Diabetes.[A2358, A2359, A2360, A44] Insulin is typically prescribed for the management of diabetes mellitus to mimic the activity of endogenously produced human insulin, a peptide hormone produced by beta...
Approved
Matched Description: … Insulin detemir is a long-acting form of insulin used for the treatment of hyperglycemia caused by Type ... [A2358, A2359, A2360, A44] Insulin is also used in the treatment of Type 2 Diabetes (T2D), another form ... 1 and Type 2 Diabetes. …
Matched Categories: … Alimentary Tract and Metabolism ... Amino Acids, Peptides, and Proteins ... Hormones, Hormone Substitutes, and Hormone Antagonists …
Matched Categories: … Alimentary Tract and Metabolism ... Amino Acids, Peptides, and Proteins ... Hormones, Hormone Substitutes, and Hormone Antagonists …
Elivaldogene autotemcel
Elivaldogene autotemcel is a gene therapy consisting of genetically modified autologous cells. It is used to provide functional copies of human adrenoleukodystrophy protein (ALDP) in patients with adrenoleukodystrophy, an X-linked genetic disorder characterized by missing or non-functional ABCD1 gene that codes for ALDP. ALDP is a key protein that normally...
Approved
Matched Description: … destruction of myelin, which is an insulating layer and essential component of nerves. ... Without sufficient levels of functional ALDP, VLCFAs accumulate in the body leading to inflammation and ... It was approved by the European Commission in July 2021 under the market name Skysona, and was later …
Matched Categories: … Cellular and Gene Therapy ... Alimentary Tract and Metabolism ... Various Alimentary Tract and Metabolism Products …
Matched Categories: … Cellular and Gene Therapy ... Alimentary Tract and Metabolism ... Various Alimentary Tract and Metabolism Products …
Propanoic acid
Sodium propionate is the sodium salt of propionic acid that exists as colorless, transparent crystals or a granular crystalline powder. It is considered generally recognized as safe (GRAS) food ingredient by FDA, where it acts as an antimicrobial agent for food preservation and flavoring agent. Its use as a food...
Approved
Vet approved
Matched Description: … as safe (GRAS) food ingredient by FDA, where it acts as an antimicrobial agent for food preservation and …
Peginterferon alfa-2a
Peginterferon alfa-2a is a form of recombinant interferon used as part of combination therapy to treat chronic Hepatitis C, an infectious liver disease caused by infection with Hepatitis C Virus (HCV). HCV is a single-stranded RNA virus that is categorized into nine distinct genotypes, with genotype 1 being the most...
Approved
Investigational
Matched Description: … Peginterferon alfa-2a is a form of recombinant interferon used as part of combination therapy to treat ... development of endocrine and autoimmune disorders, retinopathies, cardiovascular and neuropsychiatric ... 36% for genotype 1 and 59% for genotypes 2-6 after 48 weeks of treatment. …
Matched Categories: … Amino Acids, Peptides, and Proteins ... Antineoplastic and Immunomodulating Agents ... Intercellular Signaling Peptides and Proteins …
Matched Categories: … Amino Acids, Peptides, and Proteins ... Antineoplastic and Immunomodulating Agents ... Intercellular Signaling Peptides and Proteins …
Enoxacin
A broad-spectrum 6-fluoronaphthyridinone antibacterial agent (fluoroquinolones) structurally related to nalidixic acid.
Approved
Investigational
Matched Categories: … Metabolic Side Effects of Drugs and Substances …
Gemifloxacin
Gemifloxacin is a quinolone antibacterial agent with a broad-spectrum activity that is used in the treatment of acute bacterial exacerbation of chronic bronchitis and mild-to-moderate pneumonia. It is available in oral formulations. Gemifloxacin acts by inhibiting DNA synthesis through the inhibition of both DNA gyrase and topoisomerase IV, which are...
Approved
Investigational
Matched Description: … Gemifloxacin acts by inhibiting DNA synthesis through the inhibition of both DNA gyrase and topoisomerase ... broad-spectrum activity that is used in the treatment of acute bacterial exacerbation of chronic bronchitis and …
Halcinonide
Halcinonide is a corticosteroid indicated for the relief of the inflammatory and pruritic manifestations of corticosteroid-responsive dermatoses, and is distributed as a cream and ointment. Halcinonide is marketed under the brand name Halog® by Ranbaxy Laboratories Inc. Research suggests that clobetasol propionate demonstrates superior pharmacologic efficacy in the treatment of...
Approved
Investigational
Withdrawn
Matched Description: … of corticosteroid-responsive dermatoses, and is distributed as a cream and ointment. ... Halcinonide is a corticosteroid indicated for the relief of the inflammatory and pruritic manifestations …
Nomegestrol
Nomegestrol is an ingredient in the EMA-authorised product Zoely.
Approved
Matched Categories: … nomegestrol and estrogen ... nomegestrol and estradiol ... Genito Urinary System and Sex Hormones ... Sex Hormones and Modulators of the Genital System ... Progestogens and Estrogens, Sequential Preparations …
Lasmiditan
Lasmiditan is an oral medication used in the termination of migraine headaches that was first approved for use in the United States in October 2019.[L9338,L9356] It was also approved by the European Commission on August 17, 2022. Traditionally, the triptan class of anti-migraine medications (e.g. sumatriptan) have seen preferential use...
Approved
Investigational
Matched Description: … lability and other cardiovascular side effects - for this reason, these medications are less suitable ... seen preferential use in the acute treatment of migraines due to their relatively favourable efficacy and ... Their use is not devoid of concerns, however, and their vasoconstrictive activity can lead to blood pressure …
Clobetasol
Clobetasol is under investigation for the treatment of Scleroderma. Clobetasol has been investigated for the prevention of Psoriasis and Cutaneous Atrophy Due to Corticosteroids.
Approved
Experimental
Investigational
Matched Description: … Clobetasol has been investigated for the prevention of Psoriasis and Cutaneous Atrophy Due to Corticosteroids …
Matched Categories: … clobetasol and antibiotics ... Hormones, Hormone Substitutes, and Hormone Antagonists …
Matched Categories: … clobetasol and antibiotics ... Hormones, Hormone Substitutes, and Hormone Antagonists …
Iobitridol
Iobitridol has been used in trials studying the diagnostic of Diagnostic Imaging, Coronary Artery Disease, Type 2 Diabetes Mellitus, and Coronary Atherosclerosis.
Approved
Investigational
Matched Description: … trials studying the diagnostic of Diagnostic Imaging, Coronary Artery Disease, Type 2 Diabetes Mellitus, and …
Xamoterol
Xamoterol is a β1-adrenoceptor partial agonist that has shown to improve systolic and diastolic function in studies with heart failure patients. It modulates the sympathetic control of the heart but has no agonist action on β2-adrenoceptors.
Approved
Matched Description: … Xamoterol is a β1-adrenoceptor partial agonist that has shown to improve systolic and diastolic function …
Calcium levulinate
The relatively new calcium levulinate is produced from a direct reaction between L- or levulinic acid levulose and calcium hydroxide . The resultant calcium levulinate formulation, when used as a calcium supplement, possesses a high calcium content that is observed to be 14.8% higher than the content typically found in...
Approved
Experimental
Matched Description: … milk products, soy milk and soy products with calcium nutrition [L2765]. ... relatively new calcium levulinate is produced from a direct reaction between L- or levulinic acid levulose and ... Calcium levulinate can be used alone, or with calcium lactate, calcium chloride, and other compounds, …
Matched Categories: … Alimentary Tract and Metabolism …
Matched Categories: … Alimentary Tract and Metabolism …
Prednisolone tebutate
Approved
Vet approved
Dexrazoxane
An antimitotic agent with immunosuppressive properties. Dexrazoxane, the (+)-enantiomorph of razoxane, provides cardioprotection against anthracycline toxicity. It appears to inhibit formation of a toxic iron-anthracycline complex. [PubChem]
The Food and Drug Administration has designated dexrazoxane as an orphan drug for use in the prevention or reduction in the incidence and...
Approved
Withdrawn
Matched Description: … prevention or reduction in the incidence and severity of anthracycline-induced cardiomyopathy. ... [PubChem]
The Food and Drug Administration has designated dexrazoxane as an orphan drug for use in the …
Moclobemide
A reversible monoamine oxidase inhibitor (MAOI) selective for isoform A (RIMA) used to treat major depressive disorder. Most meta-analyses and most studies indicate that in the acute management of depression, moclobemide is more efficacious than placebo medication and similarly efficacious as tricyclic antidepressants (TCA) or selective serotonin reuptake inhibitors (SSRIs)....
Approved
Investigational
Matched Description: … Most meta-analyses and most studies indicate that in the acute management of depression, moclobemide ... is more efficacious than placebo medication and similarly efficacious as tricyclic antidepressants (TCA ... Due to negligible anticholinergic and antihistaminic actions, moclobemide has been better tolerated than …
Matched Categories: … Benzamides and benzamide derivatives …
Matched Categories: … Benzamides and benzamide derivatives …
Thiotepa
N,N'N'-triethylenethiophosphoramide (ThioTEPA) is a cancer chemotherapeutic member of the alkylating agent group, now in use for over 50 years. It is a stable derivative of N,N',N''- triethylenephosphoramide (TEPA). It is mostly used to treat breast cancer, ovarian cancer and bladder cancer. It is also used as conditioning for Bone marrow...
Approved
Investigational
Matched Description: … It is mostly used to treat breast cancer, ovarian cancer and bladder cancer. …
Matched Categories: … Antineoplastic and Immunomodulating Agents …
Matched Categories: … Antineoplastic and Immunomodulating Agents …
Peramivir
Peramivir is an antiviral agent developed by Biocryst Pharmaceuticals to treat influenza A/B. The development of peramivir has been supported by the US Department of Health and Human Services as part of the government's effort to prepare for a flu pandemic. Being an influenza virus neuraminidase inhibitor, peramivir works by...
Approved
Investigational
Matched Description: … The development of peramivir has been supported by the US Department of Health and Human Services as ... the poor oral bioavailability, the oral formulation of the drug was previously abandoned by Johnson and ... in September 2017 for the treatment of acute uncomplicated influenza to pediatric patients 2 years and …
Displaying drugs 2176 - 2200 of 15156 in total