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Displaying drugs 376 - 400 of 11875 in total
Fexinidazole
Human African trypanosomiasis (HAT, also colloquially referred to as sleeping sickness), caused by T. brucei gambiense and T. brucei rhodesiense, remains a moderate risk (>1/10,000 inhabitants per year in endemic areas) despite focussed control efforts. Transmitted by the bite of an infected tsetse fly, HAT is biphasic with a first...
Approved
Investigational
Matched Description: … brucei gambiense_ and _T. brucei rhodesiense_, remains a moderate risk (>1/10,000 inhabitants per year in ... biphasic with a first (hemolymphatic) stage that progresses to a second (meningoencephalitic) stage in ... rediscovered through the Drugs for Neglected Diseases Initiative (DNDi) in 2005, is the first all-oral …
Etofamide
Etofamide is used as an antiamoebic agent. Etofamide, under the brand name Kitnos, was marketed in Brazil by Pfizer but has been discontinued .
Approved
Matched Description: … Etofamide, under the brand name Kitnos, was marketed in Brazil by Pfizer but has been discontinued [L5617 …
Pidolic acid
Pidolic acid is a naturally occurring but little-studied amino acid derivative that can be formed enzymatically or non-enzymatically and participates as a biological intermediate with unique pharmacodynamics in various chemical pathways [A32991, L2729]. Elevations of the acid in blood levels may be associated with problems of glutamine or glutathione metabolism...
Approved
Investigational
Matched Description: … Pidolic acid, in general, is found in large quantities in brain tissue and other tissues in bound form ... Although pidolic acid is included in some over-the-counter, non-prescription dietary supplements for ... of facilitating cognitive or memory enhancement, most available research suggest exercising caution in …
Fenpropidin
Fenpropidin has been investigated for the treatment of Hernia.
Approved
Experimental
Matched Categories: … Compounds used in a research, industrial, or household setting …
Calcium alginate
Approved
Experimental
Matched Categories: … Compounds used in a research, industrial, or household setting …
Raloxifene
Raloxifene is a second generation selective estrogen receptor modulator (SERM) that mediates anti-estrogenic effects on breast and uterine tissues, and estrogenic effects on bone, lipid metabolism, and blood coagulation.[A4979,T28] Exhibiting tissue-specific effects distinct from estradiol, raloxifene is the first of the benzothiophene group of antiestrogens to be labelled a SERM....
Approved
Investigational
Matched Description: … [A4977] Available in many countries worldwide, raloxifene was initially approved by the FDA in December ... women and reduction in risk for invasive breast cancer in postmenopausal women with osteoporosis or ... Due to the decline in estrogen levels in postmenopausal osteoporosis, hormone replacement therapy (HRT …
Meclofenamic acid
A non-steroidal anti-inflammatory agent with antipyretic and antigranulation activities. It also inhibits prostaglandin biosynthesis.
Approved
Vet approved
Palovarotene
Fibrodysplasia Ossificans Progressiva (FOP), with an estimated worldwide prevalence of one in 2 million individuals, is an exceptionally rare genetic disorder. FOP is caused by a gain-of-function mutation in the ACVR1/ALK2 gene which results in progressive heterotopic ossification, a process wherein connective tissues (e.g. skeletal muscle, ligaments, tendons) are replaced...
Approved
Investigational
Matched Description: … [A244920] FOP is caused by a gain-of-function mutation in the ACVR1/ALK2 gene which results in progressive ... [A244920]
Palovarotene was approved for use in Canada in January 2022 for the management of heterotopic ... Fibrodysplasia Ossificans Progressiva (FOP), with an estimated worldwide prevalence of one in 2 million …
Tacrolimus
Tacrolimus (also FK-506 or Fujimycin) is an immunosuppressive drug whose main use is after organ transplant to reduce the activity of the patient's immune system and so the risk of organ rejection. It is also used in a topical preparation in the treatment of severe atopic dermatitis, severe refractory uveitis...
Approved
Investigational
Matched Description: … It is also used in a topical preparation in the treatment of severe atopic dermatitis, severe refractory ... It was discovered in 1984 from the fermentation broth of a Japanese soil sample that contained the bacteria …
Matched Products: … Tacrolimus 0.1% In Pseudocatalase …
Matched Products: … Tacrolimus 0.1% In Pseudocatalase …
Dasatinib
Dasatinib is an orally available multikinase inhibitor indicated for the treatment of Philadelphia chromosome (Ph)-positive leukemias.[A2224,L45171] Ph is a chromosomal abnormality found in patients with chronic myelogenous leukemia (CML) and acute lymphocytic leukemia (ALL), where the ABL tyrosine kinase and the breakpoint cluster region (BCR) gene transcribe the chimeric protein...
Approved
Investigational
Matched Description: … [A2226] The use of dasatinib was first approved by the FDA in 2006.[L45171,L45186] ... [A2224,L45171] Ph is a chromosomal abnormality found in patients with chronic myelogenous leukemia (CML ... BCR-ABL is associated with the uncontrolled activity of the ABL tyrosine kinase and is involved in the …
Common carp
Common carp allergenic extract is used in allergenic testing.
Approved
Matched Description: … Common carp allergenic extract is used in allergenic testing. …
Hydroxyethyl cellulose
Hydroxyethyl cellulose is a polysaccharide derivative with gel thickening, emulsifying, bubble-forming, water-retaining and stabilizing properties. It is used as a key ingredient in many household cleaning products, lubricants and cosmetics due to its non-ionic and water-soluble nature. It is often used as an ingredient in ophthalmic pharmaceutical preparations such as...
Approved
Matched Description: … It is used as a key ingredient in many household cleaning products, lubricants and cosmetics due to its ... and adjunct agent in topical drug formulations to facilitate the delivery of drugs with hydrophobic ... It is often used as an ingredient in ophthalmic pharmaceutical preparations such as artificial tear solutions …
Matched Categories: … Compounds used in a research, industrial, or household setting …
Matched Categories: … Compounds used in a research, industrial, or household setting …
Sevoflurane
Sevoflurane is an ether inhalation anesthetic agent used to induce and maintain general anesthesia. It is a volatile, non-flammable compound with a low solubility profile and blood/gas partition coefficient. Sevoflurane was patented in 1972, was approved for clinical use in Japan in 1990, and approved by the FDA in 1996....
Approved
Vet approved
Matched Description: … [L42340] Sevoflurane was patented in 1972, was approved for clinical use in Japan in 1990, and approved ... by the FDA in 1996. ... [A249910] Therefore, it can be used for inhalational induction in adults and children for a wide variety …
Sacituzumab govitecan
Metastatic triple-negative breast cancer (mTNBC) is an aggressive form of breast cancer with limited treatment options involving cytotoxic chemotherapy agents. Targeted chemotherapy through the application of antibody-conjugated agents (ADCs) is a recent advance in cancer treatment. One such ADC is sacituzumab govitecan, which combines a humanized anti-trophoblast cell-surface antigen 2...
Approved
Investigational
Matched Description: … Targeted chemotherapy through the application of antibody-conjugated agents (ADCs) is a recent advance in ... [A193653] In November 2021 and July 20 2023, sacituzumab govitecan was also approved by the European …
Flunitrazepam
Flunitrazepam is a benzodiazepine with pharmacologic actions similar to those of diazepam that can cause anterograde amnesia. Some reports indicate that it is used as a date rape drug and suggest that it may precipitate violent behavior. The United States Government has banned the importation of this drug.
Approved
Illicit
Relugolix
Relugolix is a gonadotropin-releasing hormone (GnRH) receptor antagonist used in the treatment of several hormone-responsive conditions. It was first approved in Japan in 2019, under the brand name Relumina, for the symptomatic treatment of uterine fibroids, and more recently by the United States' FDA in 2020, under the brand name...
Approved
Investigational
Matched Description: … It was first approved in Japan in 2019, under the brand name Relumina, for the symptomatic treatment ... [L27996] In addition to its relative ease-of-use, relugolix was shown to be superior in the depression ... [L42150] Relugolix has also been studied in the symptomatic treatment of endometriosis. …
Icodextrin
Icodextrin is an iso-osmotic peritoneal dialysis solution containing glucose polymers. It is used primarily for ambulatory peritoneal dialysis (CAPD) of diabetic patients and automated peritoneal dialysis (APD) for patients with end-stage renal disease. It is injected as a solution into the peritoneal cavity. The drug is absorbed via convective transport...
Approved
Investigational
Matched Categories: … Compounds used in a research, industrial, or household setting …
Influenza B virus B/Maryland/15/2016 BX-69A antigen (UV, formaldehyde inactivated)
A seasonally-specific component of the influenza vaccine. The influenza vaccine, also known as the "flu shot", is a vaccine that protects against infection from the influenza viruses. Vaccines provide protection from influenza by exposing the immune system to the virus (or parts of the virus) which stimulates an immunological defence...
Approved
Matched Description: … , or inactivated, through exposure to heat or chemicals such as formaldehyde 3. ... Inactivated vaccines contain a virus particle that has been grown in media and then subsequently killed ... In contrast, live vaccines are produced from "wild-type" or disease-causing viruses that have been attenuated …
Influenza B virus B/Hubei-Wujiagang/158/2009 BX-39 antigen (formaldehyde inactivated)
A seasonally-specific component of the influenza vaccine. The influenza vaccine, also known as the "flu shot", is a vaccine that protects against infection from the influenza viruses. Vaccines provide protection from influenza by exposing the immune system to the virus (or parts of the virus) which stimulates an immunological defence...
Approved
Matched Description: … , or inactivated, through exposure to heat or chemicals such as formaldehyde 3. ... Inactivated vaccines contain a virus particle that has been grown in media and then subsequently killed ... In contrast, live vaccines are produced from "wild-type" or disease-causing viruses that have been attenuated …
Influenza B virus B/Austria/1359417/2021 BVR-26 antigen (UV, formaldehyde inactivated)
A seasonally-specific component of the influenza vaccine. The influenza vaccine, also known as the "flu shot", is a vaccine that helps to protect against infection from influenza viruses. These vaccines provide protection from influenza by exposing the immune system to the virus (or parts of the virus) which results in...
Approved
Matched Description: … , or inactivated, through exposure to heat or chemicals such as formaldehyde. ... Inactivated vaccines contain a virus particle that has been grown in media and then subsequently killed ... protection from influenza by exposing the immune system to the virus (or parts of the virus) which results in …
Bromocriptine
Bromocriptine mesylate is a semisynthetic ergot alkaloid derivative with potent dopaminergic activity. It inhibits prolactin secretion and may be used to treat dysfunctions associated with hyperprolactinemia. Bromocriptine is also indicated for the management of signs and symptoms of Parkinsonian Syndrome, as well as the treatment of acromegaly. Bromocriptine has been...
Approved
Investigational
Withdrawn
Matched Description: … In 1995, the FDA withdrew the approval of bromocriptine mesylate for the prevention of physiological ... pulmonary fibrosis, and can also cause sustained suppression of somatotropin (growth hormone) secretion in …
Isoniazid
Antibacterial agent used primarily as a tuberculostatic. It remains the treatment of choice for tuberculosis.
Approved
Investigational
Ivosidenib
Ivosidenib is a first-in-class isocitrate dehydrogenase-1 (IDH1) inhibitor. IDH1 is an enzyme that is often mutated and overexpressed in some cancers, leading to aberrant cell growth and proliferation. Ivosidenib inhibits mutated IDH1, blocking the enzymatic activity and further differentiation of cancer cells. Ivosidenib was granted accelerated approval by the FDA...
Approved
Investigational
Matched Description: … relapsed of refractory acute myeloid leukemia in adults. ... [L46287] It was fully approved by the EMA in May 2023.[L46596] ... Ivosidenib is a first-in-class isocitrate dehydrogenase-1 (IDH1) inhibitor. …
Methimazole
Methimazole is a thionamide antithyroid agent that inhibits the synthesis of thyroid hormones.[A184559,A184733,A184694] It was first introduced as an antithyroid agent in 1949 and is now commonly used in the management of hyperthyroidism, particularly in those for whom more aggressive options such as surgery or radioactive iodine therapy are inappropriate.[L8336,L8339]...
Approved
Matched Description: … commonly used in the management of hyperthyroidism, particularly in those for whom more aggressive options ... of methimazole appears to be unclear[A184643,A184757,A184763] and its place in therapy may change in ... [A184559,A184733,A184694] It was first introduced as an antithyroid agent in 1949[A184502] and is now …
Displaying drugs 376 - 400 of 11875 in total