Displaying drugs 4151 - 4175 of 11638 in total
Efineptakin alfa
Efineptakin alfa (also known as NT-I7) is a long-acting human interleukin-7 (IL-7) fusion protein that promotes T-cell development, contributing to the immune response. Compared to endogenous IL-7, NT-I7 is more stable and potent, has a longer half-life, and has better bioavailability. This drug is currently being investigated in the areas...
Investigational
Matched Synonyms: … Recombinant human interleukin-7 fused to a hybrid crystallizable fragment region of a human antibody ... Recombinant human interleukin-7 fused to a hybrid crystallizable fragment region of a human antibody …
Matched Description: … Efineptakin alfa (also known as NT-I7) is a long-acting human interleukin-7 (IL-7) fusion protein that ... Compared to endogenous IL-7, NT-I7 is more stable and potent, has a longer half-life, and has better …
Matched Description: … Efineptakin alfa (also known as NT-I7) is a long-acting human interleukin-7 (IL-7) fusion protein that ... Compared to endogenous IL-7, NT-I7 is more stable and potent, has a longer half-life, and has better …
8-Benzyl-2-Hydroxy-2-(4-Hydroxy-Benzyl)-6-(4-Hydroxy-Phenyl)-2h-Imidazo[1,2-a]Pyrazin-3-One
Experimental
Matched Name: … 8-Benzyl-2-Hydroxy-2-(4-Hydroxy-Benzyl)-6-(4-Hydroxy-Phenyl)-2h-Imidazo[1,2-a]Pyrazin-3-One …
Matched Iupac: … (2S)-8-benzyl-2-hydroxy-6-(4-hydroxyphenyl)-2-[(4-hydroxyphenyl)methyl]-2H,3H-imidazo[1,2-a]pyrazin-3 …
Matched Iupac: … (2S)-8-benzyl-2-hydroxy-6-(4-hydroxyphenyl)-2-[(4-hydroxyphenyl)methyl]-2H,3H-imidazo[1,2-a]pyrazin-3 …
7A-[(4-cyanophenyl)methyl]-6-(3,5-dichlorophenyl)-5-oxo-2,3,5,7A-tetrahydro-1H-pyrrolo[1,2-A]pyrrole-7-carbonitrile
Experimental
Matched Name: … 7A-[(4-cyanophenyl)methyl]-6-(3,5-dichlorophenyl)-5-oxo-2,3,5,7A-tetrahydro-1H-pyrrolo[1,2-A]pyrrole- …
Inodiftagene vixteplasmid
Inodiftagene vixteplasmid is a plasmid DNA vector encoding the diphtheria toxin A (dT-a) gene under transcriptional regulation of the promoter region of the human H19 gene (an imprinted maternally expressed non-protein coding gene).
Investigational
Matched Synonyms: … dT-A-H19 ... diphtheria-toxin-A-H19 …
Matched Description: … Inodiftagene vixteplasmid is a plasmid DNA vector encoding the diphtheria toxin A (dT-a) gene under transcriptional …
Matched Description: … Inodiftagene vixteplasmid is a plasmid DNA vector encoding the diphtheria toxin A (dT-a) gene under transcriptional …
Uridine diphosphate glucose
A key intermediate in carbohydrate metabolism. Serves as a precursor of glycogen, can be metabolized into UDPgalactose and UDPglucuronic acid which can then be incorporated into polysaccharides as galactose and glucuronic acid. Also serves as a precursor of sucrose lipopolysaccharides, and glycosphingolipids.
Experimental
Matched Synonyms: … Co-waldenase ... Co-galactoisomerase …
Matched Description: … A key intermediate in carbohydrate metabolism. ... Also serves as a precursor of sucrose lipopolysaccharides, and glycosphingolipids. ... Serves as a precursor of glycogen, can be metabolized into UDPgalactose and UDPglucuronic acid which …
Matched Description: … A key intermediate in carbohydrate metabolism. ... Also serves as a precursor of sucrose lipopolysaccharides, and glycosphingolipids. ... Serves as a precursor of glycogen, can be metabolized into UDPgalactose and UDPglucuronic acid which …
2,2,2-TRIFLUORO-1-{5-[(3-PHENYL-5,6-DIHYDROIMIDAZO[1,2-A]PYRAZIN-7(8H)-YL)CARBONYL]THIOPHEN-2-YL}ETHANE-1,1-DIOL
Experimental
Matched Name: … 2,2,2-TRIFLUORO-1-{5-[(3-PHENYL-5,6-DIHYDROIMIDAZO[1,2-A]PYRAZIN-7(8H)-YL)CARBONYL]THIOPHEN-2-YL}ETHANE …
Matched Iupac: … 2,2,2-trifluoro-1-(5-{3-phenyl-5H,6H,7H,8H-imidazo[1,2-a]pyrazine-7-carbonyl}thiophen-2-yl)ethane-1,1 …
Matched Iupac: … 2,2,2-trifluoro-1-(5-{3-phenyl-5H,6H,7H,8H-imidazo[1,2-a]pyrazine-7-carbonyl}thiophen-2-yl)ethane-1,1 …
N-{3-[(7ar,12as,12bs)-7-Oxo-1,3,4,6,7,7a,12a,12b-Octahydroindolo[2,3-a]Quinolizin-12(2h)-Yl]Propyl}Propane-2-Sulfonamide
Experimental
Matched Name: … N-{3-[(7ar,12as,12bs)-7-Oxo-1,3,4,6,7,7a,12a,12b-Octahydroindolo[2,3-a]Quinolizin-12(2h)-Yl]Propyl}Propane …
Matched Iupac: … N-{3-[(12bS)-7-oxo-1H,2H,3H,4H,6H,7H,12H,12bH-indolo[2,3-a]quinolizin-12-yl]propyl}propane-2-sulfonamide …
Matched Iupac: … N-{3-[(12bS)-7-oxo-1H,2H,3H,4H,6H,7H,12H,12bH-indolo[2,3-a]quinolizin-12-yl]propyl}propane-2-sulfonamide …
Lutikizumab
Lutikizumab is under investigation in clinical trial NCT02087904 (A Study Evaluating the Safety, Efficacy, and Pharmacodynamic Effects of ABT-981 in Patients With Knee Osteoarthritis).
Investigational
Matched Synonyms: … (synthetic human a-1234138 heavy chain), disulfide with synthetic human a-1234138 light chain, dimer …
Matched Description: … Lutikizumab is under investigation in clinical trial NCT02087904 (A Study Evaluating the Safety, Efficacy …
Matched Description: … Lutikizumab is under investigation in clinical trial NCT02087904 (A Study Evaluating the Safety, Efficacy …
OXI-4503
OXI-4503 is investigated in clinical trials for treating cancer/tumors. OXI-4503 is a solid. OXI-4503 blocks and destroys tumor vasculature, resulting in extensive tumor cell death and necrosis. OXI-4503 (combretastatin A1 di-phosphate / CA1P) is a unique and highly potent, dual-mechanism vascular disrupting agent (VDA). In addition, however, preclinical data demonstrates...
Investigational
Matched Synonyms: … Combretastatin A-1 bis(phosphate) …
Matched Description: … OXI-4503 is a solid. ... OXI-4503 (combretastatin A1 di-phosphate / CA1P) is a unique and highly potent, dual-mechanism vascular ... Preclinical studies have demonstrated that OXI-4503 has (i) single-agent activity against a range of …
Matched Description: … OXI-4503 is a solid. ... OXI-4503 (combretastatin A1 di-phosphate / CA1P) is a unique and highly potent, dual-mechanism vascular ... Preclinical studies have demonstrated that OXI-4503 has (i) single-agent activity against a range of …
N-Ethylretinamide
N-Ethylretinamide is the ethylamide of all-trans B-retinoic acid.
Experimental
Matched Synonyms: … Vitamin A acid ethylamide …
Matched Categories: … Vitamin A …
Matched Categories: … Vitamin A …
GTS-21
GTS-21 (also known as DMBX-A), is a novel, small-molecule, orally active and selective alpha-7 nicotinic acetylcholine (nACh) receptor agonist that has demonstrated memory and cognition enhancement activity in human clinical trials. Athenagen licensed the exclusive rights to the compound and a related library of analogs as part of the acquisition...
Investigational
Matched Synonyms: … DMXB-A …
Matched Description: … GTS-21 (also known as DMBX-A), is a novel, small-molecule, orally active and selective alpha-7 nicotinic ... Athenagen licensed the exclusive rights to the compound and a related library of analogs as part of the ... cognitive enhancement across all doses, with a statistically significant improvement in attention related …
Matched Description: … GTS-21 (also known as DMBX-A), is a novel, small-molecule, orally active and selective alpha-7 nicotinic ... Athenagen licensed the exclusive rights to the compound and a related library of analogs as part of the ... cognitive enhancement across all doses, with a statistically significant improvement in attention related …
Vidutolimod
Vidutolimod is a Toll-like receptor 9 (TLR9) agonist. It is an investigational cancer vaccine.
Investigational
Matched Synonyms: … Dna, d(g-g-g-g-g-g-g-g-g-g-g-a-c-g-a-t-c-g-t-c-g-g-g-g-g-g-g-g-g-g) ... Cmp-001 component cpg-a oligodeoxynucleotide tlr9 agonist …
Matched Description: … Vidutolimod is a Toll-like receptor 9 (TLR9) agonist. It is an investigational cancer vaccine. …
Matched Description: … Vidutolimod is a Toll-like receptor 9 (TLR9) agonist. It is an investigational cancer vaccine. …
1-(5-OXO-2,3,5,9B-TETRAHYDRO-1H-PYRROLO[2,1-A]ISOINDOL-9-YL)-3-(5-PYRROLIDIN-2-YL-1H-PYRAZOL-3-YL)-UREA
Experimental
Matched Name: … 1-(5-OXO-2,3,5,9B-TETRAHYDRO-1H-PYRROLO[2,1-A]ISOINDOL-9-YL)-3-(5-PYRROLIDIN-2-YL-1H-PYRAZOL-3-YL)-UREA …
Matched Iupac: … 3-[(9bS)-5-oxo-1H,2H,3H,5H,9bH-benzo[a]pyrrolizin-9-yl]-1-{5-[(2S)-pyrrolidin-2-yl]-1H-pyrazol-3-yl}urea …
Matched Iupac: … 3-[(9bS)-5-oxo-1H,2H,3H,5H,9bH-benzo[a]pyrrolizin-9-yl]-1-{5-[(2S)-pyrrolidin-2-yl]-1H-pyrazol-3-yl}urea …
NVL-655
NVL-655 is an orally bioavailable, brain-penetrant anaplastic lymphoma kinase (ALK) inhibitor inhibitor being investigated for the treatment of non-small cell lung cancer.
Investigational
Matched Synonyms: … an orally bioavailable ALK inhibitor (a macrocyclic compound containing nitrogen heterocycles) …
LDN-193189
Investigational
Matched Synonyms: … 4-(6-(4-(piperazin-1-yl)phenyl_pyrazolo[1,5-a]pyrimidin-3-yl)quinoline ... Quinoline, 4-(6-(4-(1-piperazinyl)phenyl)pyrazolo(1,5-a)pyrimidin-3-yl)- …
Matched Iupac: … 4-{6-[4-(piperazin-1-yl)phenyl]pyrazolo[1,5-a]pyrimidin-3-yl}quinoline …
Matched Iupac: … 4-{6-[4-(piperazin-1-yl)phenyl]pyrazolo[1,5-a]pyrimidin-3-yl}quinoline …
Tildacerfont
Tildacerfont is a corticotropin-releasing factor receptor-1 antagonist containing an unfused thiazole ring
Investigational
Matched Synonyms: … (1,3-a)pyrimidine ... 3-(5-chloro-2-morpholin-4-yl-thiazol-4-yl)-7-(1-ethyl-propyl)-2,5-dimethyl-pyrazolo(1,5-a)pyrimidine ... Pyrazolo(1,5-a)pyrimidine, 3-(4-chloro-2-(4-morpholinyl)-5-thiazolyl)-7-(1-ethylpropyl)-2,5-dimethyl- …
Matched Iupac: … 4-{5-chloro-4-[2,5-dimethyl-7-(pentan-3-yl)pyrazolo[1,5-a]pyrimidin-3-yl]-1,3-thiazol-2-yl}morpholine …
Matched Description: … Tildacerfont is a corticotropin-releasing factor receptor-1 antagonist containing an unfused thiazole …
Matched Iupac: … 4-{5-chloro-4-[2,5-dimethyl-7-(pentan-3-yl)pyrazolo[1,5-a]pyrimidin-3-yl]-1,3-thiazol-2-yl}morpholine …
Matched Description: … Tildacerfont is a corticotropin-releasing factor receptor-1 antagonist containing an unfused thiazole …
Ochromycinone
Ochromycinone is under investigation in clinical trial NCT01047943 (STA-21 Topical Efficacy on Psoriasis).
Investigational
Matched Synonyms: … -methyl-8-hydroxy-1,2,3,4,7,12-hexahydrobenzo(a)anthracene-1,7,12-trione ... Benz(a)anthracene-1,7,12(2h)-trione, 3,4-dihydro-8-hydroxy-3-methyl-, (s)- …
Tefidsogene civaparvovec
Tefidsogene civaparvovec, formerly known as SB-913, is an investigational therapy for genome editing. It consists of an adeno-associated virus (AAV) type 2/6 vector and a zinc finger nuclease (ZFN) system that inserts a correct copy of the Iduronate 2-Sulfatase (IDS) gene into the albumin locus in hepatocytes. Developed by Sangamo...
Experimental
Matched Synonyms: … EXONS 2-9 FROM HIDS AND A SPLICE ACCEPTOR SITE (SA) ... A RECOMBINANT NON-REPLICATING ADENO-ASSOCIATED VIRUS TYPE 2/6 (RAAV REP2-CAP6) VECTOR, WHICH CONTAINS ... A PROMOTER-LESS HUMAN IDURONATE 2-SULFATASE (HIDS) TRANSGENE CASSETTE, ENCODING PARTS OF EXON 1 PLUS …
Matched Description: … It consists of an adeno-associated virus (AAV) type 2/6 vector and a zinc finger nuclease (ZFN) system ... that inserts a correct copy of the Iduronate 2-Sulfatase (IDS) gene into the albumin locus in hepatocytes …
Matched Description: … It consists of an adeno-associated virus (AAV) type 2/6 vector and a zinc finger nuclease (ZFN) system ... that inserts a correct copy of the Iduronate 2-Sulfatase (IDS) gene into the albumin locus in hepatocytes …
Evorpacept
evorpacept is under investigation in clinical trial NCT04755244 (A Study of Evorpacept (ALX148) With Venetoclax and Azacitidine for Acute Myeloid Leukemia (ASPEN-05)).
Investigational
Matched Synonyms: … A CD47-binding, fusion protein containing a high affinity engineered D1 domain of human signal regulatory ... protein alpha (SIRPalpha) variant 1 (v1) genetically linked to a modified and inactive Fc domain of …
Matched Description: … evorpacept is under investigation in clinical trial NCT04755244 (A Study of Evorpacept (ALX148) With …
Matched Description: … evorpacept is under investigation in clinical trial NCT04755244 (A Study of Evorpacept (ALX148) With …
(5S,8R,9S,10S,13R,14S,17S)-13-{2-[(3,5-DIFLUOROBENZYL)OXY]ETHYL}-17-HYDROXY-10-METHYLHEXADECAHYDRO-3H-CYCLOPENTA[A]PHENANTHREN-3-ONE
Experimental
Matched Name: … ,13R,14S,17S)-13-{2-[(3,5-DIFLUOROBENZYL)OXY]ETHYL}-17-HYDROXY-10-METHYLHEXADECAHYDRO-3H-CYCLOPENTA[A] …
Matched Iupac: … 9bS,11aR)-11a-{2-[(3,5-difluorophenyl)methoxy]ethyl}-1-hydroxy-9a-methyl-hexadecahydro-1H-cyclopenta[a] …
Matched Iupac: … 9bS,11aR)-11a-{2-[(3,5-difluorophenyl)methoxy]ethyl}-1-hydroxy-9a-methyl-hexadecahydro-1H-cyclopenta[a] …
4-[(3AS,4R,7R,8AS,8BR)-2-(1,3-BENZODIOXOL-5-YLMETHYL)-7-HYDROXY-1,3-DIOXODECAHYDROPYRROLO[3,4-A]PYRROLIZIN-4-YL]BENZENECARBOXIMIDAMIDE
Experimental
Matched Name: … 4-[(3AS,4R,7R,8AS,8BR)-2-(1,3-BENZODIOXOL-5-YLMETHYL)-7-HYDROXY-1,3-DIOXODECAHYDROPYRROLO[3,4-A]PYRROLIZIN …
Matched Iupac: … 4-[(3aS,4R,7R,8aS,8bR)-2-[(2H-1,3-benzodioxol-5-yl)methyl]-7-hydroxy-1,3-dioxo-decahydropyrrolo[3,4-a] …
Matched Iupac: … 4-[(3aS,4R,7R,8aS,8bR)-2-[(2H-1,3-benzodioxol-5-yl)methyl]-7-hydroxy-1,3-dioxo-decahydropyrrolo[3,4-a] …
Displaying drugs 4151 - 4175 of 11638 in total