Displaying drugs 4276 - 4300 of 8295 in total
NP-51
Investigational
Porphobilinogen
Porphobilinogen is a pyrrole involved in porphyrin metabolism. It is generated by the enzyme ALA dehydratase, and converted into hydroxymethyl bilane by the enzyme porphobilinogen deaminase.
Experimental
Matched Synonyms: … 5-(Aminomethyl)-4-(carboxymethyl)-1H-pyrrole-3-propionic acid …
Matched Iupac: … 3-[5-(aminomethyl)-4-(carboxymethyl)-1H-pyrrol-3-yl]propanoic acid …
Matched Iupac: … 3-[5-(aminomethyl)-4-(carboxymethyl)-1H-pyrrol-3-yl]propanoic acid …
SNS-314
SNS-314 is a potent and selective inhibitor of Aurora kinases A, B, and C. Proliferating cells treated with SNS-314 bypass the mitotic spindle checkpoint and fail to undergo cytokinesis, leading to multiple rounds of endoreduplication and eventually cell death. SNS-314 inhibits tumor growth in a variety of preclinical models, and...
Investigational
Matched Synonyms: … 1-(3-chlorophenyl)-3-{5-[2-(thieno[3,2-d]pyrimidin-4-ylamino)ethyl]-1,3-thiazol-2-yl}urea …
Matched Iupac: … 1-(3-chlorophenyl)-3-{5-[2-({thieno[3,2-d]pyrimidin-4-yl}amino)ethyl]-1,3-thiazol-2-yl}urea …
Matched Iupac: … 1-(3-chlorophenyl)-3-{5-[2-({thieno[3,2-d]pyrimidin-4-yl}amino)ethyl]-1,3-thiazol-2-yl}urea …
AL6528
Experimental
Matched Iupac: … 2-(3-methoxyphenyl)-1,1-dioxo-2H-1lambda6-thieno[3,2-e][1,2]thiazine-6-sulfonamide …
LX6171
LX6171 is an oral drug candidate that was generated by Lexicon medicinal chemists and is being developed to treat disorders characterized by cognitive impairment, such as Alzheimer's disease, schizophrenia or vascular dementia.
Investigational
CR6086
CR6086 is under investigation in clinical trial NCT03163966 (A Study of the EP4 Antagonist CR6086 in Combination With Methotrexate, in Dmard-naïve Patients With Early Rheumatoid Arthritis).
Investigational
Matched Iupac: … 4-[1-(6-{[4-(trifluoromethyl)phenyl]methyl}-6-azaspiro[2.5]octane-5-amido)cyclopropyl]benzoic acid …
(2S,3S)-4-cyclopropyl-3-{(3R,5R)-3-[2-fluoro-4-(methylsulfonyl)phenyl]-1,2,4-oxadiazolidin-5-yl}-1-[(3S)-3-fluoropyrrolidin-1-yl]-1-oxobutan-2-amine
Experimental
Matched Name: … (2S,3S)-4-cyclopropyl-3-{(3R,5R)-3-[2-fluoro-4-(methylsulfonyl)phenyl]-1,2,4-oxadiazolidin-5-yl}-1-[( …
Matched Iupac: … (2S,3S)-2-amino-4-cyclopropyl-3-[(3R)-3-(2-fluoro-4-methanesulfonylphenyl)-1,2,4-oxadiazolidin-5-yl]- …
Matched Iupac: … (2S,3S)-2-amino-4-cyclopropyl-3-[(3R)-3-(2-fluoro-4-methanesulfonylphenyl)-1,2,4-oxadiazolidin-5-yl]- …
Galunisertib
Galunisertib has been used in trials studying the basic science and treatment of Glioma, Neoplasms, Solid Tumor, GLIOBLASTOMA, and Prostate Cancer, among others.
Investigational
Matched Iupac: … 4-[2-(6-methylpyridin-2-yl)-4H,5H,6H-pyrrolo[1,2-b]pyrazol-3-yl]quinoline-6-carboxamide …
Ersodetug
Investigational
Candoxatril
Candoxatril is the orally-active prodrug of candoxatrilat (UK-73967), a potent neutral endopeptidase (NEP) inhibitor.
Experimental
Matched Synonyms: … 4-({1-[(S)-2-(indan-5-yloxycarbonyl)-3-(2-methoxy-ethoxy)-propyl]-cyclopentanecarbonyl}-amino)-cyclohexanecarboxylic ... [4(S)-cis]-4-[[[1-[3-[(2,3-dihydro-1H-Indeb5-yl)oxy]-2-[(2-methoxyethoxy)methyl]-3-oxopropyl]cyclopentyl …
Matched Iupac: … (1s,4s)-4-{1-[(2S)-3-(2,3-dihydro-1H-inden-5-yloxy)-2-[(2-methoxyethoxy)methyl]-3-oxopropyl]cyclopentaneamido …
Matched Iupac: … (1s,4s)-4-{1-[(2S)-3-(2,3-dihydro-1H-inden-5-yloxy)-2-[(2-methoxyethoxy)methyl]-3-oxopropyl]cyclopentaneamido …
AVE-2865
Experimental
Matched Iupac: … 1-[2-({[(2-chloro-4,5-difluorophenyl)formamido]carbonyl}amino)-4-fluorophenyl]piperidine-4-carboxylic …
Oxolinic acid
Experimental
Matched Iupac: … 5-ethyl-8-oxo-2H,5H,8H-[1,3]dioxolo[4,5-g]quinoline-7-carboxylic acid …
Matched Categories: … 4-Quinolones …
Matched Categories: … 4-Quinolones …
3,4-Dihydro-2h-Pyrrolium-5-Carboxylate
Experimental
Matched Name: … 3,4-Dihydro-2h-Pyrrolium-5-Carboxylate …
Matched Iupac: … 3,4-dihydro-2H-pyrrol-1-ium-5-carboxylate …
Matched Iupac: … 3,4-dihydro-2H-pyrrol-1-ium-5-carboxylate …
5,8-Di-Amino-1,4-Dihydroxy-Anthraquinone
Experimental
3',5'-DIFLUOROBIPHENYL-4-CARBOXYLIC ACID
Experimental
Matched Name: … 3',5'-DIFLUOROBIPHENYL-4-CARBOXYLIC ACID …
Matched Iupac: … 3',5'-difluoro-[1,1'-biphenyl]-4-carboxylic acid …
Matched Iupac: … 3',5'-difluoro-[1,1'-biphenyl]-4-carboxylic acid …
N-(3,5-dibromo-4-hydroxyphenyl)benzamide
Experimental
Matched Name: … N-(3,5-dibromo-4-hydroxyphenyl)benzamide …
Matched Iupac: … N-(3,5-dibromo-4-hydroxyphenyl)benzamide …
Matched Iupac: … N-(3,5-dibromo-4-hydroxyphenyl)benzamide …
Anbenitamab
Investigational
Matched Synonyms: … extracellular domains II and IV of HER 2 and FC-fusion bispecific IgG1 antibody inhibiting PD-L1 and CTLA-4 …
Cordycepin
Cordycepin has been used in trials studying the treatment of Leukemia.
Investigational
Matched Iupac: … (2R,3R,5S)-2-(6-amino-9H-purin-9-yl)-5-(hydroxymethyl)oxolan-3-ol …
Saredutant
Saredutant (SR 48968) is a neurokinin-2 antagonist drug being developed as an antidepressant and anxiolytic by Sanofi-Aventis.
Investigational
Matched Iupac: … N-[(2S)-2-(3,4-dichlorophenyl)-4-(4-acetamido-4-phenylpiperidin-1-yl)butyl]-N-methylbenzamide …
VPO-227
Investigational
Matched Synonyms: … ]heptadeca-2(7),3,5,10,16-pentaene-4-carboxylic acid ... (+-)-9-(5-bromofuran-2-yl)-12,14-dimethyl-13,15-dioxo-17-phenyl-8-oxa-1,12,14-triazatetracyclo[8.7.0.02,7.011,16 …
Matched Iupac: … }.0^{11,16}]heptadeca-2,4,6,10,16-pentaene-4-carboxylic acid ... 9-(5-bromofuran-2-yl)-12,14-dimethyl-13,15-dioxo-17-phenyl-8-oxa-1,12,14-triazatetracyclo[8.7.0.0^{2,7 …
Matched Iupac: … }.0^{11,16}]heptadeca-2,4,6,10,16-pentaene-4-carboxylic acid ... 9-(5-bromofuran-2-yl)-12,14-dimethyl-13,15-dioxo-17-phenyl-8-oxa-1,12,14-triazatetracyclo[8.7.0.0^{2,7 …
CA4P
CA4P has been shown in the laboratory to shut down the blood supply to tumours. It is one of the first vascular targeting drugs to be tested in patients. This drug was originally isolated from the African Bush Willow. The first studies in patients with this drug were aimed at...
Investigational
Matched Iupac: … 5-[(2S)-2-hydroxy-2-(3,4,5-trimethoxyphenyl)ethyl]-2-methoxyphenol …
Displaying drugs 4276 - 4300 of 8295 in total