Advanced Filter

Filter by Group

Filter by Market Availability

Clear
Displaying drugs 451 - 475 of 10872 in total

Tolbutamide

Tolbutamide is an oral antihyperglycemic agent used for the treatment of non-insulin-dependent diabetes mellitus (NIDDM). It is structurally similar to acetohexamide, chlorpropamide and tolazamide and belongs to the sulfonylurea class of insulin secretagogues, which act by stimulating β cells of the pancreas to release insulin. Sulfonylureas increase both basal insulin...
Approved
Investigational
Matched Description: … Medications in this class differ in their dose, rate of absorption, duration of action, route of elimination ... The risk of hypoglycemia is increased in elderly, debilitated and malnourished individuals. ... Tolbutamide appears to be metabolized in the liver. …
Matched Categories: … Drugs Used in Diabetes ... combinations of sulfonamides …

Influenza B virus B/Singapore/INFTT-16-0610/2016 hemagglutinin antigen (MDCK cell derived, propiolactone inactivated)

A seasonally-specific component of the influenza vaccine. The influenza vaccine, also known as the "flu shot", is a vaccine that protects against infection from the influenza viruses. Vaccines provide protection from influenza by exposing the immune system to the virus (or parts of the virus) which stimulates an immunological defence...
Approved
Matched Description: … Inactivated vaccines contain a virus particle that has been grown in media and then subsequently killed ... In contrast, live vaccines are produced from "wild-type" or disease-causing viruses that have been attenuated ... Inactivated virus cannot replicate, and therefore cannot cause disease from infection, even in immunocompromised …

Wormwood

Wormwood is a plant/plant extract used in some OTC (over-the-counter) products. It is not an approved drug.
Approved
Experimental
Matched Description: … Wormwood is a plant/plant extract used in some OTC (over-the-counter) products. …

Human immunoglobulin G

Intravenous immunoglobulin (IVIg) is a mixture of IgG1 and other antibodies derived from healthy human plasma via Cohn fractionation. The purification process includes cold alcohol fractionation, polyethylene glycol precipitation, and ion exchange chromatography. IVIg contains the same distribution of IgG antibody subclasses as is found in the general human population....
Approved
Investigational
Matched Description: … IVIg is used in the treatment of immunodeficiencies, as well as autoimmune and inflammatory disorders ... IVIg contains the same distribution of IgG antibody subclasses as is found in the general human population ... Intravenous immunoglobulin (IVIg) is a mixture of IgG1 and other antibodies derived from healthy human …

Inonotus obliquus fruiting body

Inonotus obliquus fruiting body is a plant/plant extract used in some OTC (over-the-counter) products. It is not an approved drug.
Approved
Experimental
Matched Description: … Inonotus obliquus fruiting body is a plant/plant extract used in some OTC (over-the-counter) products …

Palovarotene

Fibrodysplasia Ossificans Progressiva (FOP), with an estimated worldwide prevalence of one in 2 million individuals, is an exceptionally rare genetic disorder. FOP is caused by a gain-of-function mutation in the ACVR1/ALK2 gene which results in progressive heterotopic ossification, a process wherein connective tissues (e.g. skeletal muscle, ligaments, tendons) are replaced...
Approved
Investigational
Matched Description: … [A244920] FOP is caused by a gain-of-function mutation in the ACVR1/ALK2 gene which results in progressive ... [A244920] Palovarotene was approved for use in Canada in January 2022 for the management of heterotopic ... Fibrodysplasia Ossificans Progressiva (FOP), with an estimated worldwide prevalence of one in 2 million …

Starch, corn

Corn starch refers to the starch extracted from the corn grain that is commonly used as a food ingredient and chemical additive. Starch is any of a group of polysaccharides of the general formula (C6-H10-O5)n, composed of a long-chain polymer of glucose in the form of amylose and amylopectin. Starch...
Approved
Nutraceutical
Matched Description: … polymer of glucose in the form of amylose and amylopectin. ... Starch is the chief storage form of energy reserve (carbohydrates) in plants. ... found in topical drugs as a skin protectant. …
Matched Categories: … Compounds used in a research, industrial, or household setting …

Cilgavimab

SARS-CoV-2, the causative agent of COVID-19, enters cells via the interaction between the trimeric spike (S) glycoprotein and host cell angiotensin-converting enzyme 2 (ACE2). Blocking the interaction between the receptor-binding domain (RBD) of the S1 subunit and ACE2 inhibits viral host cell entry; animal studies indicate that antibodies capable of...
Approved
Investigational
Matched Description: … December 9, 2021, for the pre-exposure prophylaxis of COVID-19 in individuals at increased risk for ... [L41549] In October 2022, the FDA and Health Canada released safety alerts regarding the risk of developing ... [A243351, A243356, L39411] As the RBD binding site of cilgavimab does not overlap with that of [tixagevimab …

Tixagevimab

SARS-CoV-2, the causative agent of COVID-19, enters cells via the interaction between the trimeric spike (S) glycoprotein and host cell angiotensin-converting enzyme 2 (ACE2). Blocking the interaction between the receptor-binding domain (RBD) of the S1 subunit and ACE2 inhibits viral host cell entry; animal studies indicate that antibodies capable of...
Approved
Investigational
Matched Description: … December 9, 2021, for the pre-exposure prophylaxis of COVID-19 in individuals at increased risk for ... [L41549] In October 2022, the FDA and Health Canada released safety alerts regarding the risk of ... [A243351, A243356, L39411] As the RBD binding site of tixagevimab does not overlap with that of [cilgavimab …

Febuxostat

Febuxostat is a non-purine xanthine oxidase (XO) inhibitor. In early 2008, febuxostat was granted marketing authorization by the European Commission for the treatment of chronic hyperuricemia and gout. In the following year, the FDA for approved febuxostat for use in the chronic management of hyperuricemia in adult patients with gout...
Approved
Matched Description: … of febuxostat in patients with cardiovascular diseases. ... [A230548] In the following year, the FDA for approved febuxostat for use in the chronic management of ... [L32238] Gout is a form of arthritis that is caused by the accumulation of uric acid crystal in or around …
Matched Salts cas: … 442664-09-7 …

Influenza B virus B/Phuket/3073/2013 BVR-1B antigen (propiolactone inactivated)

A seasonally-specific component of the influenza vaccine. The influenza vaccine, also known as the "flu shot", is a vaccine that protects against infection from the influenza viruses. Vaccines provide protection from influenza by exposing the immune system to the virus (or parts of the virus) which stimulates an immunological defence...
Approved
Matched Description: … Inactivated vaccines contain a virus particle that has been grown in media and then subsequently killed ... In contrast, live vaccines are produced from "wild-type" or disease-causing viruses that have been attenuated ... Inactivated virus cannot replicate, and therefore cannot cause disease from infection, even in immunocompromised …

Influenza B virus B/Washington/02/2019 antigen (UV, formaldehyde inactivated)

A seasonally-specific component of the influenza vaccine. The influenza vaccine, also known as the "flu shot", is a vaccine that protects against infection from the influenza viruses. Vaccines provide protection from influenza by exposing the immune system to the virus (or parts of the virus) which stimulates an immunological defence...
Approved
Matched Description: … Inactivated vaccines contain a virus particle that has been grown in media and then subsequently killed ... In contrast, live vaccines are produced from "wild-type" or disease-causing viruses that have been attenuated ... Inactivated virus cannot replicate, and therefore cannot cause disease from infection, even in immunocompromised …

Betamethasone phosphate

Betamethasone phosphate is a prodrug that is rapidly hydrolyzed, providing rapidly accessible betamethasone to agonize glucocorticoid receptors. Betamethasone provides greater anti-inflammatory activity than prednisolone with less sodium and water retention. Betamethasone sodium phosphate was granted FDA approval on 3 March 1965.
Approved
Vet approved
Matched Iupac: … {2-[(1R,2S,3aS,3bS,9aS,9bR,10S,11aS)-9b-fluoro-1,10-dihydroxy-2,9a,11a-trimethyl-7-oxo-1H,2H,3H,3aH,3bH …

Nintedanib

Nintedanib is a small molecule kinase inhibitor used in the treatment of pulmonary fibrosis, systemic sclerosis-associated interstitial lung disease, and non-small cell lung cancer (NSCLC).[L8453,L8459] It was first approved for use in the United States in 2014. Within the spectrum of idiopathic pulmonary fibrosis treatment options, nintedanib is currently one...
Approved
Matched Description: … Nintedanib is a small molecule kinase inhibitor used in the treatment of pulmonary fibrosis, systemic ... [L8453,L8459] It was first approved for use in the United States in 2014. ... [L8453] Within the spectrum of idiopathic pulmonary fibrosis treatment options, nintedanib is currently …

Tecovirimat

The World Health Organization declared smallpox, a contagious and sometimes fatal infectious disease, eradicated in 1980. However, there have been longstanding concerns that smallpox may be used as a bioweapon.[A35133,L3614] Tecovirimat is an antiviral drug that was identified via a high-throughput screen in 2002. It is effective against all orthopoxviruses,...
Approved
Investigational
Matched Description: … L40159] Other than smallpox, tecovirimat is also indicated to treat complications due to replication of ... the approval from the European Commission in January 2022. ... Health Organization declared smallpox, a contagious and sometimes fatal infectious disease, eradicated in …

Pegunigalsidase alfa

Pegunigalsidase alfa (PRX-102) is a recombinant form of human α-galactosidase-A indicated for long-term enzyme replacement therapy in patients with Fabry disease, a rare genetic disorder characterized by the deficiency of alpha-galactosidase A.[A259352,L46342] Unlike other forms of recombinant alpha-galactosidase A, such as agalsidase alfa and agalsidase beta, pegunigalsidase alfa uses a...
Approved
Investigational
Matched Description: … [A259347,A259352] In May 2023, the EMA granted marketing authorization to pegunigalsidase alfa in ... enzyme replacement therapy in patients with Fabry disease, a rare genetic disorder characterized by ... the deficiency of alpha-galactosidase A. …

Tapinarof

Tapinarof is a novel, first-in-class, small-molecule AhR agonist that is indicated for the treatment of adult psoriasis. It is available as a topical cream to be applied to the affected area once daily.[L41845, A248790] Tapiranof was first discovered as a metabolite (3,5-dihydroxy-4-isopropylstilbene) produced in Photorhabdus luminescens, a gram-negative bacillus that...
Approved
Investigational
Matched Description: … [A248790] In 1959, it was noticed that _Heterorhabditis_ with a high amount of 3,5-dihydroxy-4-isopropylstilbene ... of adult psoriasis. ... [A248790] Tapinarof received initial approval from the FDA in 2022.[L41845] …

Fenpropidin

Fenpropidin has been investigated for the treatment of Hernia.
Approved
Experimental
Matched Description: … Fenpropidin has been investigated for the treatment of Hernia. …
Matched Categories: … Compounds used in a research, industrial, or household setting …

Calcium alginate

Approved
Experimental
Matched Categories: … Compounds used in a research, industrial, or household setting …

Nevirapine

A potent, non-nucleoside reverse transcriptase inhibitor (NNRTI) used in combination with nucleoside analogues for treatment of Human Immunodeficiency Virus Type 1 (HIV-1) infection and AIDS. Structurally, nevirapine belongs to the dipyridodiazepinone chemical class.
Approved
Matched Iupac: … 2-cyclopropyl-7-methyl-2,4,9,15-tetraazatricyclo[9.4.0.0^{3,8}]pentadeca-1(11),3,5,7,12,14-hexaen-10- …
Matched Description: … analogues for treatment of Human Immunodeficiency Virus Type 1 (HIV-1) infection and AIDS. ... A potent, non-nucleoside reverse transcriptase inhibitor (NNRTI) used in combination with nucleoside …
Matched Categories: … Antivirals used in combination for the treatment of HIV infections ... Inducers of Drug Clearance ... Metabolic Side Effects of Drugs and Substances …

Luspatercept

Luspatercept is a recombinant fusion protein comprised of a modified extracellular domain of activin receptor type IIB fused to the FC domain of human IgG1.[A187829,L42455] It was first approved for use in the United States in November 2019 under the brand name Reblozyl® for the treatment of anemia in patients...
Approved
Investigational
Matched Description: … name Reblozyl® for the treatment of anemia in patients with beta thalassemia who require regular blood ... Luspatercept is a recombinant fusion protein comprised of a modified extracellular domain of activin ... [A187829,L42455] It was first approved for use in the United States in November 2019 under the brand …

Clozapine

Clozapine is a tricyclic dibenzodiazepine, classified as an atypical antipsychotic agent. Clozapine displays affinity to various neuroreceptors with a particularly low affinity to the dopamine receptors, thus breaking the mold of first-generation antipsychotics and deeming it "atypical". . This low affinity to dopamine receptors results in fewer extrapyramidal side effects,...
Approved
Matched Description: … Despite its effectiveness in treating both positive and negative symptoms of schizophrenia, clozapine ... was briefly removed from the market in various jurisdictions in 1970 due to severe agranulocytosis. ... various neuroreceptors with a particularly low affinity to the dopamine receptors, thus breaking the mold of …

Crizotinib

Crizotinib is a tyrosine kinase receptor inhibitor used for the treatment of anaplastic lymphoma kinase (ALK) or ROS1-positive non-small cell lung cancer (NSCLC) tumors, as well as ALK-positive anaplastic large cell lymphoma (ALCL) and inflammatory myofibroblastic tumor (IMT). By targeting the echinoderm microtubule-associated protein-like 4 (EML4)-ALK fusion protein, crizotinib offers...
Approved
Investigational
Matched Description: … treating NSCLC in patients with this type of rearrangement. ... Crizotinib is a tyrosine kinase receptor inhibitor used for the treatment of anaplastic lymphoma kinase ... Second- and third-generation ALK-tyrosine kinase-inhibitors have overcome many of the pharmacodynamic …

Tannic acid

Tannic acid is a polyphenolic compound. It is a type of the commercially available tannins. It acts as a weak acid. Tannic acid is found in the nutgalls formed by insects on twigs of certain oak trees (Quercus infectoria and other Quercus species). It is removed and used as medicine....
Approved
Matched Description: … Tannic acid is found in the nutgalls formed by insects on twigs of certain oak trees (Quercus infectoria ... In the old days it was used as antidote against different poisons. ... It is a type of the commercially available tannins. It acts as a weak acid. …
Matched Categories: … Compounds used in a research, industrial, or household setting …
Matched Products: … Zilactin Medicated Gel 7% …

Hydroxyethyl cellulose

Hydroxyethyl cellulose is a polysaccharide derivative with gel thickening, emulsifying, bubble-forming, water-retaining and stabilizing properties. It is used as a key ingredient in many household cleaning products, lubricants and cosmetics due to its non-ionic and water-soluble nature. It is often used as an ingredient in ophthalmic pharmaceutical preparations such as...
Approved
Matched Description: … and adjunct agent in topical drug formulations to facilitate the delivery of drugs with hydrophobic ... It is used as a key ingredient in many household cleaning products, lubricants and cosmetics due to its ... It is often used as an ingredient in ophthalmic pharmaceutical preparations such as artificial tear solutions …
Matched Categories: … Compounds used in a research, industrial, or household setting …
Displaying drugs 451 - 475 of 10872 in total