Displaying drugs 4801 - 4825 of 5395 in total
Rosomidnar
Investigational
Matched Synonyms: … (3'-5')d(c-a-c-g-c-a-c-g-c-g-c-a-t-c-c-c-c-g-c-c-c-g-t-g) …
Matched Categories: … Nucleic Acids, Nucleotides, and Nucleosides …
Matched Categories: … Nucleic Acids, Nucleotides, and Nucleosides …
Dihydrostreptomycin
Dihydrostreptomycin is an aminoglycoside antibiotic. In humans, the use of dihydrostreptomycin has been associated with ototoxicity. The FDA withdrew its approval for the use of all drug products containing dihydrostreptomycin sulfate.
Approved
Investigational
Vet approved
Withdrawn
Matched Synonyms: … N,N'''-[(1R,2R,3S,4R,5R,6S)-4-({5-deoxy-2-O-[2-deoxy-2-(methylamino)-a-L-glucopyranosyl]-3-C-(hydroxymethyl ... N,N'''-[(1R,2R,3S,4R,5R,6S)-4-({5-deoxy-2-O-[2-deoxy-2-(methylamino)-α-L-glucopyranosyl]-3-C-(hydroxymethyl ... N,N'''-[(1R,2R,3S,4R,5R,6S)-4-({5-deoxy-2-O-[2-deoxy-2-(methylamino)-alpha-L-glucopyranosyl]-3-C-(hydroxymethyl …
Matched Iupac: … N-[(1S,2R,3R,4S,5R,6R)-3-carbamimidamido-6-{[(2R,3R,4R,5S)-3-{[(2S,3S,4S,5R,6S)-4,5-dihydroxy-6-(hydroxymethyl ... )-3-(methylamino)oxan-2-yl]oxy}-4-hydroxy-4-(hydroxymethyl)-5-methyloxolan-2-yl]oxy}-2,4,5-trihydroxycyclohexyl …
Matched Description: … The FDA withdrew its approval for the use of all drug products containing dihydrostreptomycin sulfate …
Matched Salts name: … Dihydrostreptomycin sulfate …
Matched Iupac: … N-[(1S,2R,3R,4S,5R,6R)-3-carbamimidamido-6-{[(2R,3R,4R,5S)-3-{[(2S,3S,4S,5R,6S)-4,5-dihydroxy-6-(hydroxymethyl ... )-3-(methylamino)oxan-2-yl]oxy}-4-hydroxy-4-(hydroxymethyl)-5-methyloxolan-2-yl]oxy}-2,4,5-trihydroxycyclohexyl …
Matched Description: … The FDA withdrew its approval for the use of all drug products containing dihydrostreptomycin sulfate …
Matched Salts name: … Dihydrostreptomycin sulfate …
(10R)-10-methyl-3-(6-methylpyridin-3-yl)-9,10,11,12-tetrahydro-8H-[1,4]diazepino[5',6':4,5]thieno[3,2-f]quinolin-8-one
Experimental
Matched Name: … (10R)-10-methyl-3-(6-methylpyridin-3-yl)-9,10,11,12-tetrahydro-8H-[1,4]diazepino[5',6':4,5]thieno[3,2 …
Matched Iupac: … (15R)-15-methyl-5-(6-methylpyridin-3-yl)-11-thia-6,14,17-triazatetracyclo[8.8.0.0^{2,7}.0^{12,18}]octadeca …
Matched Iupac: … (15R)-15-methyl-5-(6-methylpyridin-3-yl)-11-thia-6,14,17-triazatetracyclo[8.8.0.0^{2,7}.0^{12,18}]octadeca …
Ombitasvir
Ombitasvir is a direct acting antiviral medication used as part of combination therapy to treat chronic Hepatitis C, an infectious liver disease caused by infection with Hepatitis C Virus (HCV). HCV is a single-stranded RNA virus that is categorized into nine distinct genotypes, with genotype 1 being the most common...
Approved
Investigational
Matched Synonyms: … -(4-tert-butylphenyl)pyrrolidine-2,5-diyl]bis{(4,1-phenylene)carbamoyl(2S)pyrrolidine-2,1-diyl[(2S)-3- …
Matched Iupac: … N-[(2S)-1-[(2S)-2-({4-[(2S,5S)-1-(4-tert-butylphenyl)-5-{4-[(2S)-1-[(2S)-2-[(methoxycarbonyl)amino]-3- ... methylbutanoyl]pyrrolidine-2-amido]phenyl}pyrrolidin-2-yl]phenyl}carbamoyl)pyrrolidin-1-yl]-3-methyl- …
Matched Description: … option when used in combination with other antivirals for genotypes 1a, 1b, and 4 [L852]. ... Ombitasvir is an inhibitor of NS5A, a protein essential for viral replication and virion assembly [FDA ... without cirrhosis, and when combined with [DB00811] for the treatment of HCV genotype 1a with or without …
Matched Categories: … Amino Acids, Peptides, and Proteins ... Amino Acids ... Imino Acids ... Amino Acids, Cyclic ... Amino Acids, Essential …
Matched Iupac: … N-[(2S)-1-[(2S)-2-({4-[(2S,5S)-1-(4-tert-butylphenyl)-5-{4-[(2S)-1-[(2S)-2-[(methoxycarbonyl)amino]-3- ... methylbutanoyl]pyrrolidine-2-amido]phenyl}pyrrolidin-2-yl]phenyl}carbamoyl)pyrrolidin-1-yl]-3-methyl- …
Matched Description: … option when used in combination with other antivirals for genotypes 1a, 1b, and 4 [L852]. ... Ombitasvir is an inhibitor of NS5A, a protein essential for viral replication and virion assembly [FDA ... without cirrhosis, and when combined with [DB00811] for the treatment of HCV genotype 1a with or without …
Matched Categories: … Amino Acids, Peptides, and Proteins ... Amino Acids ... Imino Acids ... Amino Acids, Cyclic ... Amino Acids, Essential …
Trisaccharide A
Investigational
Matched Synonyms: … 3-o-(2-acetamido-2-deoxy-.alpha.-d-galactopyranosyl)-2-o-(.alpha.-l-fucopyranosyl)-d-galactose …
Matched Iupac: … 3S,4R,5S,6S)-3,4,5-trihydroxy-6-methyloxan-2-yl]oxy}hexan-3-yl]oxy}oxan-3-yl]acetamide ... N-[(2R,3R,4R,5R,6R)-4,5-dihydroxy-6-(hydroxymethyl)-2-{[(2R,3S,4S,5R)-4,5,6-trihydroxy-1-oxo-2-{[(2S, …
Matched Iupac: … 3S,4R,5S,6S)-3,4,5-trihydroxy-6-methyloxan-2-yl]oxy}hexan-3-yl]oxy}oxan-3-yl]acetamide ... N-[(2R,3R,4R,5R,6R)-4,5-dihydroxy-6-(hydroxymethyl)-2-{[(2R,3S,4S,5R)-4,5,6-trihydroxy-1-oxo-2-{[(2S, …
ABBV-CLS-7262
Investigational
Matched Synonyms: … Sodium ({(2S)-1,4-bis[2-(4-chloro-3- fluorophenoxy)acetamido]bicyclo[2.2.2]octan-2- yl}oxy)methyl hydrogen …
Matched Iupac: … sodium 2-amino-2-(hydroxymethyl)propane-1,3-diol {[(2S)-1,4-bis[2-(4-chloro-3-fluorophenoxy)acetamido …
Matched Iupac: … sodium 2-amino-2-(hydroxymethyl)propane-1,3-diol {[(2S)-1,4-bis[2-(4-chloro-3-fluorophenoxy)acetamido …
(2E)-1-[2-hydroxy-4-methoxy-5-(3-methylbut-2-en-1-yl)phenyl]-3-(4-hydroxyphenyl)prop-2-en-1-one
Experimental
Matched Name: … (2E)-1-[2-hydroxy-4-methoxy-5-(3-methylbut-2-en-1-yl)phenyl]-3-(4-hydroxyphenyl)prop-2-en-1-one …
Matched Iupac: … (2E)-1-[2-hydroxy-4-methoxy-5-(3-methylbut-2-en-1-yl)phenyl]-3-(4-hydroxyphenyl)prop-2-en-1-one …
Matched Iupac: … (2E)-1-[2-hydroxy-4-methoxy-5-(3-methylbut-2-en-1-yl)phenyl]-3-(4-hydroxyphenyl)prop-2-en-1-one …
AVR-48
Investigational
Matched Synonyms: … N-((2s,3r,4r,5s,6r)-4,5-dihydroxy-6-(hydroxymethyl)-2-(4-nitrophenoxy)tetrahydro-2h-pyran-3-yl) acetamide ... N-((2S,3R,4S,5S,6R)-4,5-dihydroxy-6-(hydroxymethyl)-2-(4-nitrophenoxy)tetrahydro-2H-pyran-3-yl)acetamide …
Matched Iupac: … N-[(2S,3R,4R,5S,6R)-4,5-dihydroxy-6-(hydroxymethyl)-2-(4-nitrophenoxy)oxan-3-yl]acetamide …
Matched Iupac: … N-[(2S,3R,4R,5S,6R)-4,5-dihydroxy-6-(hydroxymethyl)-2-(4-nitrophenoxy)oxan-3-yl]acetamide …
Acimtamig
Acimtamig is a tetravalent bispecific chimeric anti-human CD30 x anti-human CD16A recombinant antibody construct.
Investigational
Matched Synonyms: … -(human FcγRIIIa receptor) (human heavy chain V-D-J region) fusion protein with peptide linker (GGS)3 ... with immunoglobulin anti-(human CD30 antigen) (human-Mus musculus single-chain Fv fragment VL-(GGS)3- …
Matched Categories: … Amino Acids, Peptides, and Proteins …
Matched Categories: … Amino Acids, Peptides, and Proteins …
1-(5-OXO-2,3,5,9B-TETRAHYDRO-1H-PYRROLO[2,1-A]ISOINDOL-9-YL)-3-(5-PYRROLIDIN-2-YL-1H-PYRAZOL-3-YL)-UREA
Experimental
Matched Name: … 1-(5-OXO-2,3,5,9B-TETRAHYDRO-1H-PYRROLO[2,1-A]ISOINDOL-9-YL)-3-(5-PYRROLIDIN-2-YL-1H-PYRAZOL-3-YL)-UREA …
Matched Iupac: … 3-[(9bS)-5-oxo-1H,2H,3H,5H,9bH-benzo[a]pyrrolizin-9-yl]-1-{5-[(2S)-pyrrolidin-2-yl]-1H-pyrazol-3-yl}urea …
Matched Iupac: … 3-[(9bS)-5-oxo-1H,2H,3H,5H,9bH-benzo[a]pyrrolizin-9-yl]-1-{5-[(2S)-pyrrolidin-2-yl]-1H-pyrazol-3-yl}urea …
Camsirubicin
GPX-150 has been used in trials studying the treatment of Soft Tissue Sarcoma and Advanced Solid Tumors - Phase 1 Population.
Investigational
Matched Synonyms: … 5(8H)-Naphthacenone, 10-((3-amino-2,3,6-trideoxy-alpha-L-lyxo-hexopyranosyl)oxy)-7,9,10,12-tetrahydro …
Matched Description: … GPX-150 has been used in trials studying the treatment of Soft Tissue Sarcoma and Advanced Solid Tumors …
Matched Salts name: … Camsirubicin hydrochloride …
Matched Description: … GPX-150 has been used in trials studying the treatment of Soft Tissue Sarcoma and Advanced Solid Tumors …
Matched Salts name: … Camsirubicin hydrochloride …
Osimertinib
Osimertinib is an oral, third-generation epidermal growth factor receptor (EGFR) tyrosine kinase inhibitor (TKI) drug developed by AstraZeneca Pharmaceuticals.[A7926,L43453] Its use is indicated for the treatment of metastatic non-small cell lung cancer (NSCLC) in cases where tumour EGFR expression is positive for the T790M mutation as detected by FDA-approved testing...
Approved
Matched Synonyms: … N-(2-{[2-(dimethylamino)ethyl](methyl)amino}-4-methoxy-5-{[4-(1-methyl-1H-indol-3-yl)pyrimidin-2-yl]amino …
Matched Iupac: … N-(2-{[2-(dimethylamino)ethyl](methyl)amino}-4-methoxy-5-{[4-(1-methyl-1H-indol-3-yl)pyrimidin-2-yl]amino …
Matched Description: … ATP binding activity to EGFR and result in poor prognosis for late-stage disease. ... testing and which has progressed following therapy with a first-generation EGFR tyrosine kinase inhibitor ... Approximately 10% of patients with NSCLC have a rapid and clinically effective response to EGFR-TKIs …
Matched Categories: … Acids, Acyclic ... Carboxylic Acids ... Antineoplastic and Immunomodulating Agents …
Matched Iupac: … N-(2-{[2-(dimethylamino)ethyl](methyl)amino}-4-methoxy-5-{[4-(1-methyl-1H-indol-3-yl)pyrimidin-2-yl]amino …
Matched Description: … ATP binding activity to EGFR and result in poor prognosis for late-stage disease. ... testing and which has progressed following therapy with a first-generation EGFR tyrosine kinase inhibitor ... Approximately 10% of patients with NSCLC have a rapid and clinically effective response to EGFR-TKIs …
Matched Categories: … Acids, Acyclic ... Carboxylic Acids ... Antineoplastic and Immunomodulating Agents …
Dimethylaminomicheliolide
Investigational
Matched Synonyms: … -, (3R,3AS,9R,9AS,9BS)- ... AZULENO(4,5-B)FURAN-2(3H)-ONE, 3-((DIMETHYLAMINO)METHYL)-3A,4,5,7,8,9,9A,9B-OCTAHYDRO-9-HYDROXY-6,9-DIMETHYL …
Matched Iupac: … (3R,3aS,9R,9aS,9bS)-3-[(dimethylamino)methyl]-9-hydroxy-6,9-dimethyl-2H,3H,3aH,4H,5H,7H,8H,9H,9aH,9bH-azuleno …
Matched Salts name: … Dimethylaminomicheliolide fumarate …
Matched Iupac: … (3R,3aS,9R,9aS,9bS)-3-[(dimethylamino)methyl]-9-hydroxy-6,9-dimethyl-2H,3H,3aH,4H,5H,7H,8H,9H,9aH,9bH-azuleno …
Matched Salts name: … Dimethylaminomicheliolide fumarate …
CBP-501
Investigational
Matched Synonyms: … D-arginine, 4-benzoyl-d-phenylalanyl-d-seryl-d-tryptophyl-d-seryl-2,3,4,5,6-pentafluoro-d-phenylalanyl-3- …
Matched Iupac: … carbamimidamidopentanamido]-4-carbamoylbutanamido]-5-carbamimidamidopentanamido]-5-carbamimidamidopentanoic acid ... (4-benzoylphenyl)propanamido]-3-hydroxypropanamido]-3-(1H-indol-3-yl)propanamido]-3-hydroxypropanamido ... ]-3-(2,3,4,5,6-pentafluorophenyl)propanamido]-3-cyclohexylpropanamido]-5-carbamimidamidopentanamido]- ... 2R)-2-[(2R)-2-[(2R)-2-[(2R)-2-[(2R)-2-[(2R)-2-[(2R)-2-[(2R)-2-[(2R)-2-[(2R)-2-[(2R)-2-[(2R)-2-amino-3- …
Matched Categories: … Amino Acids, Peptides, and Proteins ... Enzymes and Coenzymes ... Intracellular Signaling Peptides and Proteins …
Matched Iupac: … carbamimidamidopentanamido]-4-carbamoylbutanamido]-5-carbamimidamidopentanamido]-5-carbamimidamidopentanoic acid ... (4-benzoylphenyl)propanamido]-3-hydroxypropanamido]-3-(1H-indol-3-yl)propanamido]-3-hydroxypropanamido ... ]-3-(2,3,4,5,6-pentafluorophenyl)propanamido]-3-cyclohexylpropanamido]-5-carbamimidamidopentanamido]- ... 2R)-2-[(2R)-2-[(2R)-2-[(2R)-2-[(2R)-2-[(2R)-2-[(2R)-2-[(2R)-2-[(2R)-2-[(2R)-2-[(2R)-2-[(2R)-2-amino-3- …
Matched Categories: … Amino Acids, Peptides, and Proteins ... Enzymes and Coenzymes ... Intracellular Signaling Peptides and Proteins …
N-(5-CHLORO-BENZO[B]THIOPHEN-3-YLMETHYL)-2-[6-CHLORO-OXO-3-(2-PYRIDIN-2-YL-ETHYLAMINO)-2H-PYRAZIN-1-YL]-ACETAMIDE
Experimental
Matched Name: … N-(5-CHLORO-BENZO[B]THIOPHEN-3-YLMETHYL)-2-[6-CHLORO-OXO-3-(2-PYRIDIN-2-YL-ETHYLAMINO)-2H-PYRAZIN-1-YL …
Matched Iupac: … N-[(5-chloro-1-benzothiophen-3-yl)methyl]-2-[(2R,6S)-2-chloro-6-hydroxy-5-{[2-(pyridin-2-yl)ethyl]amino …
Matched Iupac: … N-[(5-chloro-1-benzothiophen-3-yl)methyl]-2-[(2R,6S)-2-chloro-6-hydroxy-5-{[2-(pyridin-2-yl)ethyl]amino …
2-Amino-3-Methyl-1-Pyrrolidin-1-Yl-Butan-1-One
Experimental
Matched Name: … 2-Amino-3-Methyl-1-Pyrrolidin-1-Yl-Butan-1-One …
Matched Iupac: … (2S)-2-amino-3-methyl-1-(pyrrolidin-1-yl)butan-1-one …
Matched Iupac: … (2S)-2-amino-3-methyl-1-(pyrrolidin-1-yl)butan-1-one …
1-(2-Fluorobenzyl)-3-Butyl-8-(N-Acetyl-4-Aminobenzyl)-Xanthine
Experimental
Matched Name: … 1-(2-Fluorobenzyl)-3-Butyl-8-(N-Acetyl-4-Aminobenzyl)-Xanthine …
Matched Iupac: … N-[4-({3-butyl-1-[(2-fluorophenyl)methyl]-2,6-dioxo-2,3,6,7-tetrahydro-1H-purin-8-yl}methyl)phenyl]acetamide …
Matched Iupac: … N-[4-({3-butyl-1-[(2-fluorophenyl)methyl]-2,6-dioxo-2,3,6,7-tetrahydro-1H-purin-8-yl}methyl)phenyl]acetamide …
3-Hydroxymethyl-5-Aziridinyl-1methyl-2-[1h-Indole-4,7-Dione]-Propanol
Experimental
Matched Name: … 3-Hydroxymethyl-5-Aziridinyl-1methyl-2-[1h-Indole-4,7-Dione]-Propanol …
Matched Iupac: … 5-(aziridin-1-yl)-3-(hydroxymethyl)-2-(3-hydroxypropyl)-1-methyl-4,7-dihydro-1H-indole-4,7-dione …
Matched Iupac: … 5-(aziridin-1-yl)-3-(hydroxymethyl)-2-(3-hydroxypropyl)-1-methyl-4,7-dihydro-1H-indole-4,7-dione …
N-(4-{2-[(3-chlorobenzyl)amino]ethyl}phenyl)thiophene-2-carboximidamide
Experimental
Matched Name: … N-(4-{2-[(3-chlorobenzyl)amino]ethyl}phenyl)thiophene-2-carboximidamide …
Matched Iupac: … (Z)-N'-[4-(2-{[(3-chlorophenyl)methyl]amino}ethyl)phenyl]thiophene-2-carboximidamide …
Matched Iupac: … (Z)-N'-[4-(2-{[(3-chlorophenyl)methyl]amino}ethyl)phenyl]thiophene-2-carboximidamide …
3-Carboxy-N,N,N-Trimethyl-2-(Octanoyloxy)Propan-1-Aminium
Experimental
Matched Name: … 3-Carboxy-N,N,N-Trimethyl-2-(Octanoyloxy)Propan-1-Aminium …
Matched Iupac: … [(2R)-3-carboxy-2-(octanoyloxy)propyl]trimethylazanium …
Matched Iupac: … [(2R)-3-carboxy-2-(octanoyloxy)propyl]trimethylazanium …
[2,4,6-Triisopropyl-Phenylsulfonyl-L-[3-Amidino-Phenylalanine]]-Piperazine-N'-Beta-Alanine
Experimental
Matched Name: … [2,4,6-Triisopropyl-Phenylsulfonyl-L-[3-Amidino-Phenylalanine]]-Piperazine-N'-Beta-Alanine …
Matched Iupac: … 3-[(2S)-3-[4-(3-aminopropanoyl)piperazin-1-yl]-3-oxo-2-[2,4,6-tris(propan-2-yl)benzenesulfonamido]propyl …
Matched Iupac: … 3-[(2S)-3-[4-(3-aminopropanoyl)piperazin-1-yl]-3-oxo-2-[2,4,6-tris(propan-2-yl)benzenesulfonamido]propyl …
4-(2-HYDROXYBENZYLAMINO)-N-(3-(4-FLUOROPHENOXY)PHENYL)PIPERIDINE-1-SULFONAMIDE
Experimental
Matched Name: … 4-(2-HYDROXYBENZYLAMINO)-N-(3-(4-FLUOROPHENOXY)PHENYL)PIPERIDINE-1-SULFONAMIDE …
Matched Iupac: … N-[3-(4-fluorophenoxy)phenyl]-4-{[(2-hydroxyphenyl)methyl]amino}piperidine-1-sulfonamide …
Matched Iupac: … N-[3-(4-fluorophenoxy)phenyl]-4-{[(2-hydroxyphenyl)methyl]amino}piperidine-1-sulfonamide …
4-(6-HYDROXY-BENZO[D]ISOXAZOL-3-YL)BENZENE-1,3-DIOL
Experimental
Matched Name: … 4-(6-HYDROXY-BENZO[D]ISOXAZOL-3-YL)BENZENE-1,3-DIOL …
Matched Iupac: … 4-(6-hydroxy-1,2-benzoxazol-3-yl)benzene-1,3-diol …
Matched Iupac: … 4-(6-hydroxy-1,2-benzoxazol-3-yl)benzene-1,3-diol …
N-(3-cyclopropyl-1H-pyrazol-5-yl)-2-(2-naphthyl)acetamide
N-(3-cyclopropyl-1H-pyrazol-5-yl)-2-(2-naphthyl)acetamide is a solid. This compound belongs to the naphthalenes. These are compounds containing a naphthalene moiety, which consists of two fused benzene rings. The proteins that N-(3-cyclopropyl-1H-pyrazol-5-yl)-2-(2-naphthyl)acetamide targets include cyclin-A2 and cyclin-dependent kinase 2.
Experimental
Matched Name: … N-(3-cyclopropyl-1H-pyrazol-5-yl)-2-(2-naphthyl)acetamide …
Matched Iupac: … N-(3-cyclopropyl-1H-pyrazol-5-yl)-2-(naphthalen-2-yl)acetamide …
Matched Description: … and cyclin-dependent kinase 2. ... N-(3-cyclopropyl-1H-pyrazol-5-yl)-2-(2-naphthyl)acetamide is a solid. ... The proteins that N-(3-cyclopropyl-1H-pyrazol-5-yl)-2-(2-naphthyl)acetamide targets include cyclin-A2 …
Matched Iupac: … N-(3-cyclopropyl-1H-pyrazol-5-yl)-2-(naphthalen-2-yl)acetamide …
Matched Description: … and cyclin-dependent kinase 2. ... N-(3-cyclopropyl-1H-pyrazol-5-yl)-2-(2-naphthyl)acetamide is a solid. ... The proteins that N-(3-cyclopropyl-1H-pyrazol-5-yl)-2-(2-naphthyl)acetamide targets include cyclin-A2 …
6-[(Z)-AMINO(IMINO)METHYL]-N-[3-(CYCLOPENTYLOXY)PHENYL]-2-NAPHTHAMIDE
Experimental
Matched Name: … 6-[(Z)-AMINO(IMINO)METHYL]-N-[3-(CYCLOPENTYLOXY)PHENYL]-2-NAPHTHAMIDE …
Matched Iupac: … 6-carbamimidoyl-N-[3-(cyclopentyloxy)phenyl]naphthalene-2-carboxamide …
Matched Iupac: … 6-carbamimidoyl-N-[3-(cyclopentyloxy)phenyl]naphthalene-2-carboxamide …
Displaying drugs 4801 - 4825 of 5395 in total