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Displaying drugs 601 - 625 of 709 in total
Queuine
Queuine is a derivative of 7-Deazaguanine. Bacteria possess the exclusive ability to synthesize queuine, which is then salvaged and passed on to plants and animals. Quantities of queuine have been found in tomatoes, wheat, coconut water, and milk from humans, cows, and goats. Humans salvage and recover queuine from either...
Experimental
Nutraceutical
Matched Synonyms: … 7-(3,4-trans-4,5-cis-dihydroxy-1-cyclopenten-3-ylaminomethyl)-7-deazaguanine …
Matched Iupac: … (1R,2S,5S)-5-[({4-hydroxy-2-imino-1H,2H,7H-pyrrolo[2,3-d]pyrimidin-5-yl}methyl)amino]cyclopent-3-ene- …
Matched Description: … and goats. ... plants and animals. ... Humans salvage and recover queuine from either ingested food or the gut flora. …
Matched Iupac: … (1R,2S,5S)-5-[({4-hydroxy-2-imino-1H,2H,7H-pyrrolo[2,3-d]pyrimidin-5-yl}methyl)amino]cyclopent-3-ene- …
Matched Description: … and goats. ... plants and animals. ... Humans salvage and recover queuine from either ingested food or the gut flora. …
BI-1206
BI-1206 is a fully human immunoglobulin G1 monoclonal antibody that targets CD32b.
Investigational
Matched Description: … BI-1206 is a fully human immunoglobulin G1 monoclonal antibody that targets CD32b. …
(S)-camphor
(S)-camphor, or L(-)-Camphor, is a stereoisomer of DB01744, a bicyclic monoterpene known to potentiate both heat and cold sensations . (S)-camphor is not the naturally-occurring stereoisomer but displays similar TRPV channel affinity and current inhibition . DB01744 is isolated from the wood of the camphor laurel tree, Cinnamomum camphora, and...
Experimental
Matched Description: … by causing sensitization to heat and coolness to relieve minor muscle and joint pain [A33086]. ... It has been used as a nasal decongestant and cough suppressant, and has been topically applied due to ... its antipruritic, analgesic, and counterirritant properties [A33086]. …
Suramin
A polyanionic compound with an unknown mechanism of action. It is used parenterally in the treatment of African trypanosomiasis and it has been used clinically with diethylcarbamazine to kill the adult Onchocerca. (From AMA Drug Evaluations Annual, 1992, p1643) It has also been shown to have potent antineoplastic properties. Suramin...
Investigational
Matched Iupac: … 8-{4-methyl-3-[3-({[3-({2-methyl-5-[(4,6,8-trisulfonaphthalen-1-yl)carbamoyl]phenyl}carbamoyl)phenyl] …
Matched Description: … It is used parenterally in the treatment of African trypanosomiasis and it has been used clinically with …
Matched Salts cas: … 129-46-4 …
Matched Categories: … Agents Against Leishmaniasis and Trypanosomiasis ... Antiparasitic Products, Insecticides and Repellents …
Matched Description: … It is used parenterally in the treatment of African trypanosomiasis and it has been used clinically with …
Matched Salts cas: … 129-46-4 …
Matched Categories: … Agents Against Leishmaniasis and Trypanosomiasis ... Antiparasitic Products, Insecticides and Repellents …
Humanized monoclonal antibody Hu1B7
Investigational
BB-1701
BB-1701 is a humanized IgG1 kappa monoclonal antibody (anti-HER2 antibody) conjugated to eribulin developed by Bliss Biopharmaceutical.
Investigational
BCX10013
BCX10013 is a small molecule inhibitor of human complement factor D.
Investigational
Matched Description: … BCX10013 is a small molecule inhibitor of human complement factor D. …
SB 224289
SB-224289 is a small molecule with a high affinity for human 5-HT1B receptors.
Investigational
Matched Synonyms: … (2'-methyl-4'-(5-methyl-1,2,4-oxadiazol-3-yl)-(1,1'-biphenyl)-4-yl)(1'-methyl-6,7-dihydrospiro(furo(2,3 ... (4-(2-methyl-4-(5-methyl-1,2,4-oxadiazol-3-yl)phenyl)phenyl)-(1'-methylspiro(6,7-dihydro-2h-furo(2,3- ... 6,7-dihydro-1'-methyl-5-((2'-methyl-4'-(5-methyl-1,2,4-oxadiazol-3-yl)-1,1'-biphenyl-4-yl)carbonyl)spiro …
Matched Iupac: … 1'-methyl-5-[2'-methyl-4'-(5-methyl-1,2,4-oxadiazol-3-yl)-[1,1'-biphenyl]-4-carbonyl]-2,5,6,7-tetrahydrospiro …
Matched Description: … SB-224289 is a small molecule with a high affinity for human 5-HT1B receptors.[A253122] …
Matched Categories: … Heterocyclic Compounds, 1-Ring …
Matched Iupac: … 1'-methyl-5-[2'-methyl-4'-(5-methyl-1,2,4-oxadiazol-3-yl)-[1,1'-biphenyl]-4-carbonyl]-2,5,6,7-tetrahydrospiro …
Matched Description: … SB-224289 is a small molecule with a high affinity for human 5-HT1B receptors.[A253122] …
Matched Categories: … Heterocyclic Compounds, 1-Ring …
Oregovomab
Oregovomab is a murine monoclonal antibody that attaches to the tumor-associated antigen CA125.
Investigational
Matched Categories: … Amino Acids, Peptides, and Proteins …
NUC B1000
NUC B1000 is an expressed interfering RNA (eiRNA)- based product consisting of a plasmid DNA construct designed to produce four short interfering RNA (siRNA) molecules, formulated with a proprietary cationic-lipid delivery system. eiRNA is an approach to RNAi therapeutics, whereby a plasmid DNA coding for desired dsRNA is delivered to...
Investigational
Matched Description: … On January 11, 2008, it was announced that NUC B1000 was entering a phase 1 human safety study of its ... experimental treatment for chronic Hepatitis B virus (HBV) infection. …
(R)-warfarin
Warfarin consists of a racemic mixture of two active enantiomers—R- and S- forms—each of which is cleared by different pathways. S-warfarin is 2-5 times more potent than the R-isomer in producing an anticoagulant response.
Experimental
Matched Synonyms: … (R)-4-Hydroxy-3-(3-oxo-1-phenylbutyl)-2H-1-benzopyran-2-one ... (R)-4-Hydroxy-3-(3-oxo-1-phenylbutyl)-2-benzopyrone ... 4-hydroxy-3-[(1R)-3-oxo-1-phenylbutyl]-2H-chromen-2-one …
Matched Iupac: … 4-hydroxy-3-[(1R)-3-oxo-1-phenylbutyl]-2H-chromen-2-one …
Matched Description: … Warfarin consists of a racemic mixture of two active enantiomers—R- and S- forms—each of which is cleared …
Matched Categories: … Warfarin and isomers …
Matched Iupac: … 4-hydroxy-3-[(1R)-3-oxo-1-phenylbutyl]-2H-chromen-2-one …
Matched Description: … Warfarin consists of a racemic mixture of two active enantiomers—R- and S- forms—each of which is cleared …
Matched Categories: … Warfarin and isomers …
ARC-19499
ARC-19499 is under investigation in clinical trial NCT01191372 (First-in-Human and Proof-of-Mechanism Study of ARC19499 Administered to Hemophilia Patients).
Investigational
Matched Description: … ARC-19499 is under investigation in clinical trial NCT01191372 (First-in-Human and Proof-of-Mechanism …
Matched Categories: … Nucleic Acids, Nucleotides, and Nucleosides …
Matched Categories: … Nucleic Acids, Nucleotides, and Nucleosides …
BREN-02
BREN-02 is a recombinant human homeoprotein Engrailed 1 (rhEN1).
Investigational
Matched Description: … BREN-02 is a recombinant human homeoprotein Engrailed 1 (rhEN1). …
BJ-001
BJ-001 is a recombinant human interleukin-15/IL-15 receptor alpha complex with linked integrin-binding motif.
Investigational
Matched Description: … BJ-001 is a recombinant human interleukin-15/IL-15 receptor alpha complex with linked integrin-binding …
BW-A 58C
BW-A 58C, also known as 2-(4-tert-butylcyclohexyl)-3-hydroxy-1,4-naphthoquinone, is an experimental naphthoquinone antimalarial drug which undergoes extensive alkyl hydroxylation to a single t-butylhydroxy metabolite in man in vivo and also in human liver microsomes, where this is catalysed primarily by a 54 kDa CYP2C9 form of cytochrome P450, P450hB20-27.
Experimental
Matched Synonyms: … 2-(4'-t-Butylcyclohexyl)-3-hydroxy-1,4-naphthoquinone ... 2-(4-tert-butylcyclohexyl)-3-hydroxy-1,4-naphthoquinone ... 2-(4-(1,1-Dimethylethyl)cyclohexyl)-3-hydroxy-1,4-naphthalenedione …
Matched Iupac: … 2-(4-tert-butylcyclohexyl)-3-hydroxy-1,4-dihydronaphthalene-1,4-dione …
Matched Description: … which undergoes extensive alkyl hydroxylation to a single t-butylhydroxy metabolite in man in vivo and ... also in human liver microsomes, where this is catalysed primarily by a 54 kDa CYP2C9 form of cytochrome ... BW-A 58C, also known as 2-(4-tert-butylcyclohexyl)-3-hydroxy-1,4-naphthoquinone, is an experimental naphthoquinone …
Matched Iupac: … 2-(4-tert-butylcyclohexyl)-3-hydroxy-1,4-dihydronaphthalene-1,4-dione …
Matched Description: … which undergoes extensive alkyl hydroxylation to a single t-butylhydroxy metabolite in man in vivo and ... also in human liver microsomes, where this is catalysed primarily by a 54 kDa CYP2C9 form of cytochrome ... BW-A 58C, also known as 2-(4-tert-butylcyclohexyl)-3-hydroxy-1,4-naphthoquinone, is an experimental naphthoquinone …
AT9283
AT9283 is an aurora Kinase inhibitor developed by Astex Therapeutics for the treatment of cancer. It was discovered and developed internally using Astex’s fragment-based drug discovery platform, Pyramid.
Investigational
Matched Synonyms: … 1-Cyclopropyl-3-[3-(5-morpholin-4-ylmethyl-1H-benzoimidazol-2-yl)-1H-pyrazol-4-yl]-urea …
Matched Iupac: … N'-cyclopropyl-N-(3-{5-[(morpholin-4-yl)methyl]-1H-1,3-benzodiazol-2-yl}-1H-pyrazol-4-yl)carbamimidic …
Matched Description: … It was discovered and developed internally using Astex’s fragment-based drug discovery platform, Pyramid …
Matched Iupac: … N'-cyclopropyl-N-(3-{5-[(morpholin-4-yl)methyl]-1H-1,3-benzodiazol-2-yl}-1H-pyrazol-4-yl)carbamimidic …
Matched Description: … It was discovered and developed internally using Astex’s fragment-based drug discovery platform, Pyramid …
XTL-001
XTL001 is an investigational monoclonal antibody (MAb) product developed by XTL Biopharmaceuticals to evaluate the safety profile and antiviral activity of the compound in patients chronically infected with hepatitis B virus (HBV).
Investigational
Matched International brands: … HepeX-B …
Matched Description: … antiviral activity of the compound in patients chronically infected with hepatitis B virus (HBV). ... monoclonal antibody (MAb) product developed by XTL Biopharmaceuticals to evaluate the safety profile and …
Matched Categories: … Amino Acids, Peptides, and Proteins …
Matched Description: … antiviral activity of the compound in patients chronically infected with hepatitis B virus (HBV). ... monoclonal antibody (MAb) product developed by XTL Biopharmaceuticals to evaluate the safety profile and …
Matched Categories: … Amino Acids, Peptides, and Proteins …
MK-4721
MK-4721 is a fully human monoclonal antibody directed to Agensys’ proprietary target Prostate Stem Cell Antigen (PSCA), an antigen expressed at significant levels on tumor cells from the majority of patients with all stages of prostate, pancreatic and bladder cancers.
Investigational
Matched Description: … MK-4721 is a fully human monoclonal antibody directed to Agensys’ proprietary target Prostate Stem Cell ... significant levels on tumor cells from the majority of patients with all stages of prostate, pancreatic and …
Matched Categories: … Amino Acids, Peptides, and Proteins …
Matched Categories: … Amino Acids, Peptides, and Proteins …
Tirapazamine
Tirapazamine, also known as SR-4233, is an experimental anticancer drug that is activated in hypoxic conditions. This activation is very useful as this hypoxic state is found in human solid tumors in a common phenomenon known as tumor hypoxia. Hence, tirapazamine is solely activated in those hypoxic areas of solid...
Investigational
Matched Description: … This activation is very useful as this hypoxic state is found in human solid tumors in a common phenomenon ... Tirapazamine entered phase III testing in 2006 for patients with head and neck cancer and gynecological ... into consideration that normally, the cells in these hypoxic regions are resistant to radiotherapy and …
Matched Categories: … Heterocyclic Compounds, 1-Ring …
Matched Categories: … Heterocyclic Compounds, 1-Ring …
Morniflumate
Morniflumate is a non-steroidal anti-inflammatory drug with antipyretic properties. It is the morpholinoethyl ester of niflumic acid . In one study, post morniflumate ingestion, physical examination and clinical symptoms of those with bronchitis showed improvement .
Experimental
Matched Iupac: … 2-(morpholin-4-yl)ethyl 2-{[3-(trifluoromethyl)phenyl]amino}pyridine-3-carboxylate …
Matched Description: … In one study, post morniflumate ingestion, physical examination and clinical symptoms of those with bronchitis …
Matched Categories: … Heterocyclic Compounds, 1-Ring ... Antiinflammatory and Antirheumatic Products ... Antiinflammatory and Antirheumatic Products, Non-Steroids …
Matched Description: … In one study, post morniflumate ingestion, physical examination and clinical symptoms of those with bronchitis …
Matched Categories: … Heterocyclic Compounds, 1-Ring ... Antiinflammatory and Antirheumatic Products ... Antiinflammatory and Antirheumatic Products, Non-Steroids …
SEA-BCMA
Investigational
Matched Synonyms: … Nonfucosylated humanized immunoglobulin G1 (IgG1) monoclonal antibody targeting B-cell maturation antigen …
TPCA-1
TPCA-1 is a selective inhibitor of human IκB kinase 2 (IKK-2).
Investigational
Matched Synonyms: … 2-((aminocarbonyl)amino)-5-(4-fluorophenyl)-3-thiophenecarboxamide ... 3-thiophenecarboxamide, 2-((aminocarbonyl)amino)-5-(4-fluorophenyl)- …
Matched Name: … TPCA-1 …
Matched Iupac: … 2-(carbamoylamino)-5-(4-fluorophenyl)thiophene-3-carboxamide …
Matched Description: … TPCA-1 is a selective inhibitor of human IκB kinase 2 (IKK-2).[A253152] …
Matched Categories: … Heterocyclic Compounds, 1-Ring …
Matched Name: … TPCA-1 …
Matched Iupac: … 2-(carbamoylamino)-5-(4-fluorophenyl)thiophene-3-carboxamide …
Matched Description: … TPCA-1 is a selective inhibitor of human IκB kinase 2 (IKK-2).[A253152] …
Matched Categories: … Heterocyclic Compounds, 1-Ring …
Briakinumab
Briakinumab is a human anti-IL-12 monoclonal antibody being developed for the treatment of a number of T-cell driven autoimmune diseases. It targets and neutralize interleukin-12 and interleukin-23, two proteins associated with inflammation, such as pro-inflammatory interleukins or tumor necrosis factor- alpha. Briakinumab represents a novel approach to treating psoriasis, Multiple...
Investigational
Matched Description: … Briakinumab is a human anti-IL-12 monoclonal antibody being developed for the treatment of a number of ... It targets and neutralize interleukin-12 and interleukin-23, two proteins associated with inflammation ... other autoimmune and inflammatory disorders. …
Matched Categories: … Amino Acids, Peptides, and Proteins ... Antineoplastic and Immunomodulating Agents …
Matched Categories: … Amino Acids, Peptides, and Proteins ... Antineoplastic and Immunomodulating Agents …
BMS-986012
BMS-986012 is a human antifucosyl-GM1 antibody. It is under investigation in clinical trial NCT02815592 (Trial of BMS-986012 in Combination With Platinum and Etoposide).
Investigational
Matched Description: … BMS-986012 is a human antifucosyl-GM1 antibody. ... under investigation in clinical trial NCT02815592 (Trial of BMS-986012 in Combination With Platinum and …
Displaying drugs 601 - 625 of 709 in total