Displaying drugs 751 - 775 of 3449 in total
Influenza B virus B/Phuket/3073/2013 antigen (UV, formaldehyde inactivated)
A seasonally-specific component of the influenza vaccine. The influenza vaccine, also known as the "flu shot", is a vaccine that protects against infection from the influenza viruses. Vaccines provide protection from influenza by exposing the immune system to the virus (or parts of the virus) which stimulates an immunological defence...
Approved
Matched Name: … Influenza B virus B/Phuket/3073/2013 antigen (UV, formaldehyde inactivated) …
Matched Description: … Upon re-exposure to infectious influenza virus, the immune system is prepared to identify and destroy ... Inactivated vaccines contain a virus particle that has been grown in media and then subsequently killed ... Inactivated virus cannot replicate, and therefore cannot cause disease from infection, even in immunocompromised …
Matched Description: … Upon re-exposure to infectious influenza virus, the immune system is prepared to identify and destroy ... Inactivated vaccines contain a virus particle that has been grown in media and then subsequently killed ... Inactivated virus cannot replicate, and therefore cannot cause disease from infection, even in immunocompromised …
Influenza B virus B/Phuket/3073/2013 hemagglutinin antigen (propiolactone inactivated)
A seasonally-specific component of the influenza vaccine. The influenza vaccine, also known as the "flu shot", is a vaccine that protects against infection from the influenza viruses. Vaccines provide protection from influenza by exposing the immune system to the virus (or parts of the virus) which stimulates an immunological defence...
Approved
Matched Name: … Influenza B virus B/Phuket/3073/2013 hemagglutinin antigen (propiolactone inactivated) …
Matched Description: … Upon re-exposure to infectious influenza virus, the immune system is prepared to identify and destroy ... Inactivated vaccines contain a virus particle that has been grown in media and then subsequently killed ... Inactivated virus cannot replicate, and therefore cannot cause disease from infection, even in immunocompromised …
Matched Description: … Upon re-exposure to infectious influenza virus, the immune system is prepared to identify and destroy ... Inactivated vaccines contain a virus particle that has been grown in media and then subsequently killed ... Inactivated virus cannot replicate, and therefore cannot cause disease from infection, even in immunocompromised …
Influenza B virus B/Brisbane/9/2014 hemagglutinin antigen (formaldehyde inactivated)
A seasonally-specific component of the influenza vaccine. The influenza vaccine, also known as the "flu shot", is a vaccine that protects against infection from the influenza viruses. Vaccines provide protection from influenza by exposing the immune system to the virus (or parts of the virus) which stimulates an immunological defence...
Approved
Matched Name: … Influenza B virus B/Brisbane/9/2014 hemagglutinin antigen (formaldehyde inactivated) …
Matched Description: … Upon re-exposure to infectious influenza virus, the immune system is prepared to identify and destroy ... Inactivated vaccines contain a virus particle that has been grown in media and then subsequently killed ... Inactivated virus cannot replicate, and therefore cannot cause disease from infection, even in immunocompromised …
Matched Description: … Upon re-exposure to infectious influenza virus, the immune system is prepared to identify and destroy ... Inactivated vaccines contain a virus particle that has been grown in media and then subsequently killed ... Inactivated virus cannot replicate, and therefore cannot cause disease from infection, even in immunocompromised …
Influenza B virus B/Phuket/3073/2013 hemagglutinin antigen (formaldehyde inactivated)
A seasonally-specific component of the influenza vaccine. The influenza vaccine, also known as the "flu shot", is a vaccine that protects against infection from the influenza viruses. Vaccines provide protection from influenza by exposing the immune system to the virus (or parts of the virus) which stimulates an immunological defence...
Approved
Matched Name: … Influenza B virus B/Phuket/3073/2013 hemagglutinin antigen (formaldehyde inactivated) …
Matched Description: … Upon re-exposure to infectious influenza virus, the immune system is prepared to identify and destroy ... Inactivated vaccines contain a virus particle that has been grown in media and then subsequently killed ... Inactivated virus cannot replicate, and therefore cannot cause disease from infection, even in immunocompromised …
Matched Description: … Upon re-exposure to infectious influenza virus, the immune system is prepared to identify and destroy ... Inactivated vaccines contain a virus particle that has been grown in media and then subsequently killed ... Inactivated virus cannot replicate, and therefore cannot cause disease from infection, even in immunocompromised …
Influenza B virus B/Brisbane/46/2015 hemagglutinin antigen (propiolactone inactivated)
A seasonally-specific component of the influenza vaccine. The influenza vaccine, also known as the "flu shot", is a vaccine that protects against infection from the influenza viruses. Vaccines provide protection from influenza by exposing the immune system to the virus (or parts of the virus) which stimulates an immunological defence...
Approved
Matched Name: … Influenza B virus B/Brisbane/46/2015 hemagglutinin antigen (propiolactone inactivated) …
Matched Description: … Upon re-exposure to infectious influenza virus, the immune system is prepared to identify and destroy ... Inactivated vaccines contain a virus particle that has been grown in media and then subsequently killed ... Inactivated virus cannot replicate, and therefore cannot cause disease from infection, even in immunocompromised …
Matched Description: … Upon re-exposure to infectious influenza virus, the immune system is prepared to identify and destroy ... Inactivated vaccines contain a virus particle that has been grown in media and then subsequently killed ... Inactivated virus cannot replicate, and therefore cannot cause disease from infection, even in immunocompromised …
Influenza B virus B/Washington/02/2019 antigen (UV, formaldehyde inactivated)
A seasonally-specific component of the influenza vaccine. The influenza vaccine, also known as the "flu shot", is a vaccine that protects against infection from the influenza viruses. Vaccines provide protection from influenza by exposing the immune system to the virus (or parts of the virus) which stimulates an immunological defence...
Approved
Matched Name: … Influenza B virus B/Washington/02/2019 antigen (UV, formaldehyde inactivated) …
Matched Description: … Upon re-exposure to infectious influenza virus, the immune system is prepared to identify and destroy ... Inactivated vaccines contain a virus particle that has been grown in media and then subsequently killed ... Inactivated virus cannot replicate, and therefore cannot cause disease from infection, even in immunocompromised …
Matched Description: … Upon re-exposure to infectious influenza virus, the immune system is prepared to identify and destroy ... Inactivated vaccines contain a virus particle that has been grown in media and then subsequently killed ... Inactivated virus cannot replicate, and therefore cannot cause disease from infection, even in immunocompromised …
Cytidine 3'-monophosphate
Experimental
Matched Synonyms: … 3'-Cytidylic acid ... Cytidine 3'-phosphate …
Matched Iupac: … )-5-(4-amino-2-oxo-1,2-dihydropyrimidin-1-yl)-4-hydroxy-2-(hydroxymethyl)oxolan-3-yl]oxy}phosphonic acid …
Matched Categories: … Nucleic Acids, Nucleotides, and Nucleosides …
Matched Iupac: … )-5-(4-amino-2-oxo-1,2-dihydropyrimidin-1-yl)-4-hydroxy-2-(hydroxymethyl)oxolan-3-yl]oxy}phosphonic acid …
Matched Categories: … Nucleic Acids, Nucleotides, and Nucleosides …
Adenosine 3',5'-diphosphate
Experimental
Matched Synonyms: … Adenosine 3'-phosphate-5'-phosphate ... Phosphoadenosine phosphate ... 3'-Phosphoadenosine 5'-phosphate …
Matched Iupac: … {[(2R,3S,4R,5R)-5-(6-amino-9H-purin-9-yl)-4-hydroxy-3-(phosphonooxy)oxolan-2-yl]methoxy}phosphonic acid …
Matched Categories: … Nucleic Acids, Nucleotides, and Nucleosides …
Matched Iupac: … {[(2R,3S,4R,5R)-5-(6-amino-9H-purin-9-yl)-4-hydroxy-3-(phosphonooxy)oxolan-2-yl]methoxy}phosphonic acid …
Matched Categories: … Nucleic Acids, Nucleotides, and Nucleosides …
Ioxitalamic acid
Ioxitalamate is an ionic iodinated contrast medium. It is a first-generation contrast media formed by an ionic monomer with a high osmolarity of 1500-1800 mOsm/kg. Ioxitalamic acid in the salt forms of sodium and meglumine was developed by Liebel-Flarshem Canada Inc and approved by Health Canada in 1995. Until the...
Approved
Matched Synonyms: … Ioxitalamic acid ... Acide ioxitalamique ... Acido ioxitalamico …
Matched Name: … Ioxitalamic acid …
Matched Iupac: … 3-acetamido-5-[(2-hydroxyethyl)carbamoyl]-2,4,6-triiodobenzoic acid …
Matched Description: … [A33006] Ioxitalamic acid in the salt forms of sodium and meglumine was developed by Liebel-Flarshem ... Canada Inc and approved by Health Canada in 1995. ... [A27209] It is a first-generation contrast media formed by an ionic monomer with a high osmolarity of …
Matched Categories: … Acids, Carbocyclic ... Carboxylic Acids ... ioxitalamic acid ... Triiodobenzoic Acids …
Matched Name: … Ioxitalamic acid …
Matched Iupac: … 3-acetamido-5-[(2-hydroxyethyl)carbamoyl]-2,4,6-triiodobenzoic acid …
Matched Description: … [A33006] Ioxitalamic acid in the salt forms of sodium and meglumine was developed by Liebel-Flarshem ... Canada Inc and approved by Health Canada in 1995. ... [A27209] It is a first-generation contrast media formed by an ionic monomer with a high osmolarity of …
Matched Categories: … Acids, Carbocyclic ... Carboxylic Acids ... ioxitalamic acid ... Triiodobenzoic Acids …
Sodium phosphate P 32
Approved
Matched Synonyms: … Sodium phosphate 32P ... Sodium phosphate (32P) ... Sodium phosphate P 32 …
Matched Name: … Sodium phosphate P 32 …
Matched Iupac: … disodium hydrogen (32P)phosphate …
Matched Categories: … sodium phosphate (32P) …
Matched Name: … Sodium phosphate P 32 …
Matched Iupac: … disodium hydrogen (32P)phosphate …
Matched Categories: … sodium phosphate (32P) …
Phosphate ion P-32
Experimental
Matched Synonyms: … Phosphate-32 ... Phosphate-32P …
Matched Name: … Phosphate ion P-32 …
Matched Iupac: … (32P)phosphate …
Matched Name: … Phosphate ion P-32 …
Matched Iupac: … (32P)phosphate …
Guanosine-2'-monophosphate
Experimental
Matched Synonyms: … 2'-guanylic acid ... Guanosine 2'-phosphate …
Matched Iupac: … )-2-(2-amino-6-oxo-6,9-dihydro-1H-purin-9-yl)-4-hydroxy-5-(hydroxymethyl)oxolan-3-yl]oxy}phosphonic acid …
Matched Categories: … Nucleic Acids, Nucleotides, and Nucleosides …
Matched Iupac: … )-2-(2-amino-6-oxo-6,9-dihydro-1H-purin-9-yl)-4-hydroxy-5-(hydroxymethyl)oxolan-3-yl]oxy}phosphonic acid …
Matched Categories: … Nucleic Acids, Nucleotides, and Nucleosides …
Finafloxacin
Finafloxacin is a fluoroquinolone antibiotic indicated in the treatment of acute otitis externa (swimmer's ear) caused by the bacteria Pseudomonas aeruginosa and Staphylococcus aureus. Finafloxacin is marketed by Novartis under the brand Xtoro™, and was approved by the FDA in December 2014.
Approved
Investigational
Matched Synonyms: … 8-Cyano-1-cyclopropyl-6-fluoro-7-[(4aS,7aS)-hexahydropyrrolo[3,4-b][1,4]oxazin-6(2H)-yl]-4-oxo-1,4-dihydro ... -3-quinolinecarboxylic acid …
Matched Iupac: … -3-carboxylic acid ... 7-[(4aS,7aS)-octahydropyrrolo[3,4-b]morpholin-6-yl]-8-cyano-1-cyclopropyl-6-fluoro-4-oxo-1,4-dihydroquinoline …
Matched Description: … Finafloxacin is marketed by Novartis under the brand Xtoro™, and was approved by the FDA in December ... the bacteria Pseudomonas aeruginosa and Staphylococcus aureus. ... fluoroquinolone antibiotic indicated in the treatment of acute otitis externa (swimmer's ear) caused by …
Matched Iupac: … -3-carboxylic acid ... 7-[(4aS,7aS)-octahydropyrrolo[3,4-b]morpholin-6-yl]-8-cyano-1-cyclopropyl-6-fluoro-4-oxo-1,4-dihydroquinoline …
Matched Description: … Finafloxacin is marketed by Novartis under the brand Xtoro™, and was approved by the FDA in December ... the bacteria Pseudomonas aeruginosa and Staphylococcus aureus. ... fluoroquinolone antibiotic indicated in the treatment of acute otitis externa (swimmer's ear) caused by …
Influenza B virus B/Brisbane/60/2008 hemagglutinin antigen (propiolactone inactivated)
A seasonally-specific component of the influenza vaccine. The influenza vaccine, also known as the "flu shot", is a vaccine that protects against infection from the influenza viruses. Vaccines provide protection from influenza by exposing the immune system to the virus (or parts of the virus) which stimulates an immunological defence...
Approved
Matched Name: … Influenza B virus B/Brisbane/60/2008 hemagglutinin antigen (propiolactone inactivated) …
Matched Description: … Upon re-exposure to infectious influenza virus, the immune system is prepared to identify and destroy ... Inactivated vaccines contain a virus particle that has been grown in media and then subsequently killed ... Inactivated virus cannot replicate, and therefore cannot cause disease from infection, even in immunocompromised …
Matched Categories: … Inactivated Influenza B Virus Vaccine ... Viral Vaccines …
Matched Description: … Upon re-exposure to infectious influenza virus, the immune system is prepared to identify and destroy ... Inactivated vaccines contain a virus particle that has been grown in media and then subsequently killed ... Inactivated virus cannot replicate, and therefore cannot cause disease from infection, even in immunocompromised …
Matched Categories: … Inactivated Influenza B Virus Vaccine ... Viral Vaccines …
Influenza B virus B/Brisbane/60/2008 hemagglutinin antigen (formaldehyde inactivated)
A seasonally-specific component of the influenza vaccine. The influenza vaccine, also known as the "flu shot", is a vaccine that protects against infection from the influenza viruses. Vaccines provide protection from influenza by exposing the immune system to the virus (or parts of the virus) which stimulates an immunological defence...
Approved
Investigational
Matched Name: … Influenza B virus B/Brisbane/60/2008 hemagglutinin antigen (formaldehyde inactivated) …
Matched Description: … Upon re-exposure to infectious influenza virus, the immune system is prepared to identify and destroy ... Inactivated vaccines contain a virus particle that has been grown in media and then subsequently killed ... Inactivated virus cannot replicate, and therefore cannot cause disease from infection, even in immunocompromised …
Matched Categories: … Inactivated Influenza B Virus Vaccine ... Viral Vaccines …
Matched Description: … Upon re-exposure to infectious influenza virus, the immune system is prepared to identify and destroy ... Inactivated vaccines contain a virus particle that has been grown in media and then subsequently killed ... Inactivated virus cannot replicate, and therefore cannot cause disease from infection, even in immunocompromised …
Matched Categories: … Inactivated Influenza B Virus Vaccine ... Viral Vaccines …
Influenza B virus B/Massachusetts/2/2012 hemagglutinin antigen (formaldehyde inactivated)
A seasonally-specific component of the influenza vaccine. The influenza vaccine, also known as the "flu shot", is a vaccine that protects against infection from the influenza viruses. Vaccines provide protection from influenza by exposing the immune system to the virus (or parts of the virus) which stimulates an immunological defence...
Approved
Matched Name: … Influenza B virus B/Massachusetts/2/2012 hemagglutinin antigen (formaldehyde inactivated) …
Matched Description: … Upon re-exposure to infectious influenza virus, the immune system is prepared to identify and destroy ... Inactivated vaccines contain a virus particle that has been grown in media and then subsequently killed ... Inactivated virus cannot replicate, and therefore cannot cause disease from infection, even in immunocompromised …
Matched Description: … Upon re-exposure to infectious influenza virus, the immune system is prepared to identify and destroy ... Inactivated vaccines contain a virus particle that has been grown in media and then subsequently killed ... Inactivated virus cannot replicate, and therefore cannot cause disease from infection, even in immunocompromised …
Pyridoxal phosphate
This is the active form of vitamin B6 serving as a coenzyme for synthesis of amino acids, neurotransmitters (serotonin, norepinephrine), sphingolipids, aminolevulinic acid. During transamination of amino acids, pyridoxal phosphate is transiently converted into pyridoxamine phosphate (pyridoxamine).
Approved
Investigational
Nutraceutical
Matched Synonyms: … Pyridoxal 5-monophosphoric acid ester ... Pyridoxal 5-phosphate ... Pyridoxal 5'-phosphate …
Matched Name: … Pyridoxal phosphate …
Matched Iupac: … [(4-formyl-5-hydroxy-6-methylpyridin-3-yl)methoxy]phosphonic acid …
Matched Description: … This is the active form of vitamin B6 serving as a coenzyme for synthesis of amino acids, neurotransmitters ... During transamination of amino acids, pyridoxal phosphate is transiently converted into pyridoxamine ... phosphate (pyridoxamine). …
Matched Mixtures name: … Levomefolate Calcium, Pyridoxal 5-phosphate, Methylcobalamin and Schizochytrium DHA Oil ... Levomefolate Calcium-Pyridoxal Phosphate-Mecobalamin ... Levomefolate Calcium Pyridoxal-5 Phosphate Mecobalamin Algal …
Matched Salts name: … Pyridoxal phosphate hydrate …
Matched Categories: … Alimentary Tract and Metabolism ... Enzymes and Coenzymes ... Vitamin B Complex ... pyridoxal phosphate …
Matched Name: … Pyridoxal phosphate …
Matched Iupac: … [(4-formyl-5-hydroxy-6-methylpyridin-3-yl)methoxy]phosphonic acid …
Matched Description: … This is the active form of vitamin B6 serving as a coenzyme for synthesis of amino acids, neurotransmitters ... During transamination of amino acids, pyridoxal phosphate is transiently converted into pyridoxamine ... phosphate (pyridoxamine). …
Matched Mixtures name: … Levomefolate Calcium, Pyridoxal 5-phosphate, Methylcobalamin and Schizochytrium DHA Oil ... Levomefolate Calcium-Pyridoxal Phosphate-Mecobalamin ... Levomefolate Calcium Pyridoxal-5 Phosphate Mecobalamin Algal …
Matched Salts name: … Pyridoxal phosphate hydrate …
Matched Categories: … Alimentary Tract and Metabolism ... Enzymes and Coenzymes ... Vitamin B Complex ... pyridoxal phosphate …
Olenasufligene relduparvovec
Olenasufligene relduparvovec is under investigation in clinical trial NCT03612869 (Study of aavrh10-h.sgsh Gene Therapy in Patients With Mucopolysaccharidosis Type IIIA (MPS IIIA)). It is an adeno-associated virus (AAV) vector that delivers a functional copy of the human SGSH gene.
Investigational
Matched Synonyms: … Dna (recombinant adeno-associated virus 2 vector lys-saf302 human n-sulfoglucosamine sulfohydrolase cdna-specifying …
Matched Description: … It is an adeno-associated virus (AAV) vector that delivers a functional copy of the human SGSH gene. …
Matched Categories: … Adeno-associated Viral Vector Therapies …
Matched Description: … It is an adeno-associated virus (AAV) vector that delivers a functional copy of the human SGSH gene. …
Matched Categories: … Adeno-associated Viral Vector Therapies …
Aloe vera leaf polysaccharides
Experimental
Matched Synonyms: … Aloe barbadensis leaf polysaccharides ... Aloe vera (l.) burm.f. leaf polysaccharides …
Matched Name: … Aloe vera leaf polysaccharides …
Matched Name: … Aloe vera leaf polysaccharides …
Camellia japonica seed oil
Camellia japonica seed oil is a plant/plant extract used in some OTC (over-the-counter) products. It is not an approved drug.
Experimental
Matched Synonyms: … Japanese Camellia Seed Oil …
Iva angustifolia pollen
Iva angustifolia pollen is the pollen of the Iva angustifolia plant. Iva angustifolia pollen is mainly used in allergenic testing.
Approved
Matched Name: … Iva angustifolia pollen …
Matched Description: … Iva angustifolia pollen is the pollen of the Iva angustifolia plant. ... Iva angustifolia pollen is mainly used in allergenic testing. …
Matched Description: … Iva angustifolia pollen is the pollen of the Iva angustifolia plant. ... Iva angustifolia pollen is mainly used in allergenic testing. …
Thymol
A phenol obtained from thyme oil or other volatile oils. It is used as a stabilizer in pharmaceutic preparations. It has been used for its antiseptic, antibacterial, and antifungal actions, and was formerly used as a vermifuge. (Dorland, 28th ed)
Approved
Matched Name: … Thymol …
Matched Description: … It has been used for its antiseptic, antibacterial, and antifungal actions, and was formerly used as ... A phenol obtained from thyme oil or other volatile oils. …
Matched Mixtures name: … Royal Mouthwash Fresh and Clean Original Mint ... Neo Medicated Plaster with Ginger and Lemongrass Oil Aroma ... Be Clean …
Matched Description: … It has been used for its antiseptic, antibacterial, and antifungal actions, and was formerly used as ... A phenol obtained from thyme oil or other volatile oils. …
Matched Mixtures name: … Royal Mouthwash Fresh and Clean Original Mint ... Neo Medicated Plaster with Ginger and Lemongrass Oil Aroma ... Be Clean …
Gadofosveset trisodium
Gadofosveset trisodium is an intravenous contrast agent used with magnetic resonance angiography(MRA), which is a non-invasive way of imaging blood vessels. The agent allows for the vascular system to be imaged more clearly by the MRA. In this way, gadofosveset trisodium is used to help diagnose certain disorders of the...
Approved
Matched Name: … Gadofosveset trisodium …
Matched Description: … In this way, gadofosveset trisodium is used to help diagnose certain disorders of the heart and blood ... The agent allows for the vascular system to be imaged more clearly by the MRA. ... Gadofosveset trisodium is an intravenous contrast agent used with magnetic resonance angiography(MRA) …
Matched Salts name: … Gadofosveset trisodium monohydrate …
Matched Description: … In this way, gadofosveset trisodium is used to help diagnose certain disorders of the heart and blood ... The agent allows for the vascular system to be imaged more clearly by the MRA. ... Gadofosveset trisodium is an intravenous contrast agent used with magnetic resonance angiography(MRA) …
Matched Salts name: … Gadofosveset trisodium monohydrate …
Rosa centifolia flower oil
Rosa centifolia flower oil is a plant/plant extract used in some OTC (over-the-counter) products. It is not an approved drug.
Experimental
Matched Synonyms: … Rosa Centifolia Flower Water ... Rosa Centifolia Flower Volatile Oil …
Matched Name: … Rosa centifolia flower oil …
Matched Description: … Rosa centifolia flower oil is a plant/plant extract used in some OTC (over-the-counter) products. …
Matched Name: … Rosa centifolia flower oil …
Matched Description: … Rosa centifolia flower oil is a plant/plant extract used in some OTC (over-the-counter) products. …
TP-252
TP-252 consists of magnesium L-lysinate bis-eicosapentaenoate, an ionizable salt of eicosapentaenoic acid (EPA), currently being investigated to treat familial adenomatous polyposis.
Investigational
Matched Synonyms: … Magnesium lysinate bis eicosapentaenoate ... Magnesium, bis(l-lysinato-.kappa.n2,.kappa.o1)-, (t-4)-, (5z,8z,11z,14z,17z)-5,8,11,14,17-eicosapentaenoate ... Magnesium bislysinate biseicosapentaenoate …
Matched Iupac: … magnesium(2+) bis((5Z,8Z,11Z,14Z,17Z)-icosa-5,8,11,14,17-pentaenoic acid) bis((2S)-2,6-diaminohexanoate …
Matched Description: … TP-252 consists of magnesium L-lysinate bis-eicosapentaenoate, an ionizable salt of eicosapentaenoic ... acid (EPA), currently being investigated to treat familial adenomatous polyposis. …
Matched Categories: … Fatty Acids ... Fatty Acids, Omega-3 ... Fatty Acids, Unsaturated …
Matched Iupac: … magnesium(2+) bis((5Z,8Z,11Z,14Z,17Z)-icosa-5,8,11,14,17-pentaenoic acid) bis((2S)-2,6-diaminohexanoate …
Matched Description: … TP-252 consists of magnesium L-lysinate bis-eicosapentaenoate, an ionizable salt of eicosapentaenoic ... acid (EPA), currently being investigated to treat familial adenomatous polyposis. …
Matched Categories: … Fatty Acids ... Fatty Acids, Omega-3 ... Fatty Acids, Unsaturated …
Displaying drugs 751 - 775 of 3449 in total