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Displaying drugs 8076 - 8100 of 11017 in total
Methapyrilene, formerly marketed in many drug products, was shown to be a potent carcinogen. Manufacturers voluntarily withdrew methapyriline drug products from the market in May and June 1979.
Withdrawn
Matched Synonyms: … 2-[[2-(Dimethylamino)ethyl]-2-thenylamino]pyridine ... N,N-dimethyl-N'-pyrid-2-yl-N'-2-thenylethylenediamine ... N,N-dimethyl-N'-pyridin-2-yl-N'-(2-thienylmethyl)ethane-1,2-diamine …
Matched Iupac: … N-[2-(dimethylamino)ethyl]-N-[(thiophen-2-yl)methyl]pyridin-2-amine …
Investigational
Experimental
Matched Name: … 2''-O-[N-(3-(aminopropyl)2-aminoethyl]paromomycin …
Matched Iupac: … (2S,3S,4R,5R,6R)-5-amino-2-(aminomethyl)-6-{[(2R,3R,4R,5S)-4-{2-[(3-aminopropyl)amino]ethoxy}-5-{[(1R ... ,2R,3S,5R,6S)-3,5-diamino-2-{[(2S,3R,4R,5S,6R)-3-amino-4,5-dihydroxy-6-(hydroxymethyl)oxan-2-yl]oxy}- ... 6-hydroxycyclohexyl]oxy}-2-(hydroxymethyl)oxolan-3-yl]oxy}oxane-3,4-diol …
Experimental
Matched Name: … N-methyl-1-(2-thiophen-2-ylphenyl)methanamine …
Matched Iupac: … methyl({[2-(thiophen-2-yl)phenyl]methyl})amine …
Experimental
Matched Name: … 2-(2-METHYLPHENYL)-1H-INDOLE-6-CARBOXIMIDAMIDE …
Matched Iupac: … 2-(2-methylphenyl)-1H-indole-6-carboximidamide …
Lintuzumab actinium Ac-225 is under investigation in clinical trial NCT00672165 (Targeted Atomic Nano-Generators (Actinium-225-Labeled Humanized Anti-CD33 Monoclonal Antibody HuM195) in Patients With Advanced Myeloid Malignancies).
Investigational
Experimental
Matched Synonyms: … (2S,3R)-2-azanyl-3-methyl-pentanedioic acid …
Matched Iupac: … (2S,3R)-2-amino-3-methylpentanedioic acid …
Eldecalcitol (ED-71), a vitamin D analog, is a more potent inhibitor of bone resorption than alfacalcidol in an estrogen-deficient rat model of osteoporosis. Eldecalcitol, effectively and safely increased lumbar and hip bone mineral density (BMD) in osteoporotic patients who also received vitamin D3 supplementation.
Investigational
Matched Iupac: … (1R,2R,3R,5Z)-5-{2-[(1R,3aS,4E,7aR)-1-[(2R)-6-hydroxy-6-methylheptan-2-yl]-7a-methyl-octahydro-1H-inden ... -4-ylidene]ethylidene}-2-(3-hydroxypropoxy)-4-methylidenecyclohexane-1,3-diol …
Barnidipine is a long-acting novel calcium antagonist that belongs to the dihydropyridine (DHP) group of calcium channel blockers. Used in the treatment of hypertension, barnidipine displays high affinity for the calcium channels of the smooth muscle cells in the vascular wall and selectivity against cardiovascular L-type calcium channels . Barnidipine...
Experimental
Matched Iupac: … 3-(3S)-1-benzylpyrrolidin-3-yl 5-methyl (4S)-2,6-dimethyl-4-(3-nitrophenyl)-1,4-dihydropyridine-3,5-dicarboxylate …
Matched Description: … hypertension, the antihypertensive response from barnidipine treatment was maintained after a 1-year and 2- …
NT-501 is an intraocular implant that contains human cells that have been genetically modified to secrete ciliary neurotrophic factor (CNTF). It is under investigation for the treatment of retinitis pigmentosa and age-related macular degeneration.
Investigational
A product of fermentation. It is a component of the butanediol cycle in microorganisms. In mammals it is oxidized to carbon dioxide.
Experimental
Matched Synonyms: … (R)-2-acetoin ... (R)-3-hydroxy-2-butanone ... (R)-3-hydroxybutan-2-one …
Matched Iupac: … (3R)-3-hydroxybutan-2-one …
Experimental
Matched Synonyms: … 2-pinene ... (±)-2-pinene ... pin-2(3)-ene …
Matched Iupac: … 2,6,6-trimethylbicyclo[3.1.1]hept-2-ene …
SRT-1720 is an activator of NAD(+)-dependent histone deacetylase SIRT1.
Investigational
Matched Synonyms: … 2-quinoxalinecarboxamide, n-(2-(3-(1-piperazinylmethyl)imidazo(2,1-b)thiazol-6-yl)phenyl)- ... N-(2-(3-(1-piperazinylmethyl)imidazo(2,1-b)thiazol-6-yl)phenyl)-2-quinoxalinecarboxamide …
Matched Iupac: … N-(2-{3-[(piperazin-1-yl)methyl]imidazo[2,1-b][1,3]thiazol-6-yl}phenyl)quinoxaline-2-carboxamide …
Experimental
Matched Name: … 3'-Phosphate-Adenosine-5'-Diphosphate …
Matched Iupac: … [({[(2R,3S,4R,5R)-5-(6-amino-9H-purin-9-yl)-4-hydroxy-3-(phosphonooxy)oxolan-2-yl]methoxy}(hydroxy)phosphoryl …
Experimental
Matched Name: … Aspartyl-Adenosine-5'-Monophosphate …
Matched Iupac: … (3S)-3-amino-4-[({[(2R,3S,4R,5R)-5-(6-amino-9H-purin-9-yl)-3,4-dihydroxyoxolan-2-yl]methoxy}(hydroxy) ... phosphoryl)oxy]-4-oxobutanoic acid …
Experimental
Matched Iupac: … (5Z)-7-{2-[(1E,3S)-3-hydroxyoct-1-en-1-yl]-5-oxocyclopent-1-en-1-yl}hept-5-enoic acid …
Experimental
Matched Name: … 2-Dehydropantoate …
Matched Iupac: … 4-hydroxy-3,3-dimethyl-2-oxobutanoic acid …
LY2181308 is investigated in clinical trials for treating solid tumors. LY2181308 is a solid. LY2181308 is directed against a molecular target called survivin. LY2181308 is known to target baculoviral IAP repeat-containing protein 5. LY2181308 is an anti-sense oligonucleotide that potently downregulated survivin expression in human cancer cells derived from lung,...
Investigational
Matched Description: … LY2181308 is known to target baculoviral IAP repeat-containing protein 5. …
LY2275796 is a second-generation antisense anti-cancer drug candidate for clinical development. LY2275796 targets eukaryotic initiation factor- 4E (eIF-4E), a protein involved in the translation of key growth and survival factors that drive tumor progression, angiogenesis and metastases.
Investigational
LY2828360 is under investigation in clinical trial NCT01319929 (A Study of LY2828360 in Patients With Osteoarthritic Knee Pain).
Investigational
Matched Iupac: … 8-(2-chlorophenyl)-2-methyl-6-(4-methylpiperazin-1-yl)-9-(oxan-4-yl)-9H-purine …
Matched Categories: … Heterocyclic Compounds, 2-Ring …
Investigational
Experimental
Matched Name: … 5-Hydroxy-N-Propargyl-1(R)-Aminoindan …
Matched Iupac: … (3R)-3-[(prop-2-yn-1-yl)amino]-2,3-dihydro-1H-inden-5-ol …
Pegilodecakin is under investigation in clinical trial NCT03382912 (Study of Pegilodecakin (LY3500518) With Nivolumab Compared to Nivolumab Alone Second-line Tx in Participants With Metastatic Non-Small Cell Lung Cancer).
Investigational
Matched Synonyms: … INTERLEUKIN 10 (SYNTHETIC HUMAN), DIMER, N-TERMINAL 5-KILODALTON PEGYLATED …
Mubodina is an investigational drug developed by Adienne Pharma & Biotech. It is a recombinant human minibody directed against complement component C5. It was investigated in various conditions including primary membranoproliferative glomerulonephritis and typical hemolytic uremic syndrome.
Investigational
Experimental
Matched Synonyms: … 1-ethoxy-2-(2-methoxyethoxy)ethane …
Matched Iupac: … 1-ethoxy-2-(2-methoxyethoxy)ethane …
Displaying drugs 8076 - 8100 of 11017 in total