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Displaying drugs 8376 - 8400 of 11097 in total

INO-4800

INO-4800 is a DNA vaccine containing the full sequence for the SARS-CoV-2 Spike (S) protein in development for immunization against COVID-19. Early in vitro studies using HEK-293T cells demonstrated that the transfection of INO-4800 results in the expression of S protein by human cells.[A214475, A214478] Follow up studies in both...
Investigational
Matched Description: … (NCT04336410) was started on April 3, 2020, with an expected completion date of July 2021. ... INO-4800 is a DNA vaccine containing the full sequence for the SARS-CoV-2 Spike (S) protein in development ... Furthermore, the antibodies produced were capable of inhibiting the binding of SARS-CoV-2 to the ACE2 …

Adenosine-5'-Rp-Alpha-Thio-Triphosphate

Experimental
Matched Name: … Adenosine-5'-Rp-Alpha-Thio-Triphosphate …
Matched Iupac: … [({[(R)-{[(2R,3S,4R,5R)-5-(6-amino-9H-purin-9-yl)-3,4-dihydroxyoxolan-2-yl]methoxy}(hydroxy)sulfanylidene-lambda5 …

6-Aminohexyl-uridine-C1,5'-diphosphate

Experimental
Matched Iupac: … -2-yl]methoxy}(hydroxy)phosphoryl)oxy]phosphinic acid ... [(6-aminohexyl)oxy][({[(2R,3S,4R,5R)-5-(2,4-dioxo-1,2,3,4-tetrahydropyrimidin-1-yl)-3,4-dihydroxyoxolan …

4'-Methylene-5,8,10-trideazaaminopterin

CH-1504 is a an antirheumatic agent that has been shown in vitro to be a nonpolyglutamylatable and nonhydroxylatable antifolate that is more efficiently taken up into cells by the reduced folate carrier (RFC) system than is Methotrexate. It has been investigated for the treatment of Rheumatoid Arthritis (phase II).
Investigational
Matched Iupac: … 2-({4-[2-(2,4-diaminoquinazolin-6-yl)ethyl]phenyl}formamido)-4-methylidenepentanedioic acid …
Matched Categories: … Heterocyclic Compounds, 2-Ring …

diethyl [(1R)-1,5-diaminopentyl]boronate

Experimental

Benzquinamide

Benzquinamide is a discontinued antiemetic compound with antihistaminic, mild anticholinergic, and sedative properties. The mechanism of action is not known, but presumably benzquinamide works via antagonism of muscarinic acetycholine receptors and histamine H1 receptors.
Withdrawn
Matched Iupac: … 3-(diethylcarbamoyl)-9,10-dimethoxy-1H,2H,3H,4H,6H,7H,11bH-pyrido[2,1-a]isoquinolin-2-yl acetate …
Matched Categories: … Heterocyclic Compounds, 2-Ring …

4-[(Isopropylamino)Methyl]Phenylalanine

Experimental
Matched Iupac: … (2S)-2-amino-3-(4-{[(propan-2-yl)amino]methyl}phenyl)propanoic acid …

PD-166326

Experimental
Matched Iupac: … 6-(2,6-dichlorophenyl)-2-{[3-(hydroxymethyl)phenyl]amino}-8-methyl-7H,8H-pyrido[2,3-d]pyrimidin-7-one …

Ifetroban

Ifetroban has been used in trials studying the treatment of Skin Diseases, Autoimmune Diseases, Pathologic Processes, Scleroderma, Limited, and Scleroderma, Diffuse, among others.
Investigational
Matched Iupac: … 3-(2-{[(1S,2R,3S,4R)-3-[4-(pentylcarbamoyl)-1,3-oxazol-2-yl]-7-oxabicyclo[2.2.1]heptan-2-yl]methyl}phenyl …

Pyrrolnitrin

Experimental
Matched Iupac: … 3-chloro-4-(3-chloro-2-nitrophenyl)-1H-pyrrole …

Disomotide

Disomotide is a synthetic peptide cancer vaccine.
Investigational

Methacrylyl-Coenzyme A

Experimental
Matched Iupac: … {[(2R,3S,4R,5R)-5-(6-amino-9H-purin-9-yl)-4-hydroxy-2-({[hydroxy({hydroxy[(3R)-3-hydroxy-2,2-dimethyl ... -3-{[2-({2-[(2-methylprop-2-enoyl)sulfanyl]ethyl}carbamoyl)ethyl]carbamoyl}propoxy]phosphoryl}oxy)phosphoryl ... ]oxy}methyl)oxolan-3-yl]oxy}phosphonic acid …
Matched Categories: … Heterocyclic Compounds, 2-Ring …

Propanoyl-CoA

Experimental
Matched Iupac: … {[(2R,3S,4R,5R)-5-(6-amino-9H-purin-9-yl)-4-hydroxy-2-({[hydroxy({hydroxy[(3R)-3-hydroxy-2,2-dimethyl ... -3-[(2-{[2-(propanoylsulfanyl)ethyl]carbamoyl}ethyl)carbamoyl]propoxy]phosphoryl}oxy)phosphoryl]oxy}methyl ... )oxolan-3-yl]oxy}phosphonic acid …
Matched Categories: … Heterocyclic Compounds, 2-Ring …

N-METHYL-N-[(1R)-1-METHYL-2-PHENYLETHYL]PROP-2-EN-1-AMINE

Experimental
Matched Name: … N-METHYL-N-[(1R)-1-METHYL-2-PHENYLETHYL]PROP-2-EN-1-AMINE …
Matched Iupac: … methyl[(2R)-1-phenylpropan-2-yl](prop-2-en-1-yl)amine …

Jaspisamide A

Experimental
Matched Iupac: … }.1^{6,9}]hentriaconta-1(28),2(31),4,6(30),8,24,26(29)-heptaene-12,18-dione ... oxoundec-10-en-1-yl]-10-methoxy-11,21-dimethyl-3,7,19,27-tetraoxa-29,30,31-triazatetracyclo[24.2.1.1^{2,5 …

Exebacase

Exebacase is under investigation in clinical trial NCT03163446 (Safety, Efficacy and Pharmacokinetics of CF-301 vs. Placebo in Addition to Antibacterial Therapy for Treatment of S. Aureus Bacteremia).
Investigational

Zinc cation

Experimental
Matched Synonyms: … Zinc(2+) ... Zinc ion(2+) …
Matched Iupac: … zinc(2+) ion …

Bis(5-Amidino-Benzimidazolyl)Methane

Experimental
Matched Name: … Bis(5-Amidino-Benzimidazolyl)Methane …
Matched Iupac: … {[2-({6-[amino(iminiumyl)methyl]-1H-1,3-benzodiazol-2-yl}methyl)-1H-1,3-benzodiazol-6-yl](azaniumyl)methylidene …

4-Hydroxy-L-Threonine-5-Monophosphate

Experimental
Matched Name: … 4-Hydroxy-L-Threonine-5-Monophosphate …
Matched Iupac: … (2S,3S)-2-amino-3-hydroxy-4-(phosphonooxy)butanoic acid …

2-(Acetylamino)-2-Deoxy-6-O-Methyl-Alpha-D-Allopyranose

Experimental
Matched Name: … 2-(Acetylamino)-2-Deoxy-6-O-Methyl-Alpha-D-Allopyranose …
Matched Iupac: … (3aR,4R,5R,6R,6aS)-6-(hydroxymethyl)-2-(methylideneamino)-3aH,4H,5H,6H,6aH-cyclopenta[d][1,3]oxazole- …

(2,2-DIPHOSPHONOETHYL)(DODECYL)DIMETHYLPHOSPHONIUM

Experimental
Matched Iupac: … [2-(dodecyldimethylphosphaniumyl)-1-phosphonoethyl]phosphonic acid …

beta-D-Galactosamine

Experimental
Matched Synonyms: … 2-deoxy-2-aminogalactose ... 2-amino-2-deoxy-beta-D-galactopyranose ... 2-amino-2-deoxy-β-D-galactopyranose …
Matched Iupac: … (2R,3R,4R,5R,6R)-3-amino-6-(hydroxymethyl)oxane-2,4,5-triol …

BS-001

BS-001 is a recombinant oncolytic herpes simplex virus type II (OH2) therapeutic injection (Vero cell) for human use (rHSV2hGM-CSF).
Investigational

Idroxioleic acid

Investigational
Matched Synonyms: … 2-hydroxyoleic acid ... (z)-2-hydroxyoctadec-9-enoic acid ... Cis-2-hydroxy-9-octadecenoic acid …
Matched Iupac: … (9Z)-2-hydroxyoctadec-9-enoic acid …

Palmitoyl-Linoleoyl Phosphatidylcholine

Experimental
Matched Iupac: … (2-{[(2R)-3-(hexadecanoyloxy)-2-[(9Z,12Z)-octadeca-9,12-dienoyloxy]propyl phosphonato]oxy}ethyl)trimethylazanium …
Displaying drugs 8376 - 8400 of 11097 in total