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Displaying drugs 926 - 950 of 1245 in total

Leflunomide

Leflunomide is a pyrimidine synthesis inhibitor belonging to the DMARD (disease-modifying antirheumatic drug) class of drugs, which are chemically and pharmacologically very heterogeneous. Leflunomide was approved by FDA and in many other countries (e.g., Canada, Europe) in 1999.
Approved
Investigational
Matched Description: … belonging to the DMARD (disease-modifying antirheumatic drug) class of drugs, which are chemically and ... Leflunomide was approved by FDA and in many other countries (e.g., Canada, Europe) in 1999. …
Matched Categories: … Antineoplastic and Immunomodulating Agents ... Leflunomide and metabolite …
Matched Products: … ARAMID 10 MG FILM TABLET ,FILM TABLET, 30 ADET ... ARAMID 20 MG FILM TABLET ,FILM TABLET, 30 ADET ... ARAMID 100 MG FİLM TABLET, 3 ADET …

Favipiravir

Discovered by Toyama Chemical Co., Ltd. in Japan, favipiravir is a modified pyrazine analog that was initially approved for therapeutic use in resistant cases of influenza.[A191688,A191721] The antiviral targets RNA-dependent RNA polymerase (RdRp) enzymes, which are necessary for the transcription and replication of viral genomes.[A191688,A191772,A191775] Not only does favipiravir inhibit...
Approved
Investigational
Matched Description: … antiviral targets RNA-dependent RNA polymerase (RdRp) enzymes, which are necessary for the transcription and ... [A191688,A191772,A191775] Not only does favipiravir inhibit replication of influenza A and B, but ... the drug has shown promise in the treatment of avian influenza, and may be an alternative option for …
Matched Products: … AVIGAN Film-Coated Tablets 200mg (Favipiravir) ... KOVİPİR 200 MG FİLM KAPLI TABLET, 40 ADET ... FAVİRA 200 MG FİLM KAPLI TABLET, 40 ADET …

Edoxaban

Edoxaban is a member of the Novel Oral Anti-Coagulants (NOACs) class of drugs, and is a rapidly acting, oral, selective factor Xa inhibitor. By inhibiting factor Xa, a key protein in the coagulation cascade, edoxaban prevents the stepwise amplification of protein factors needed to form blood clots. It is indicated...
Approved
Matched Description: … INR testing, and numerous drug-drug and drug-food interactions. ... atrial fibrillation (NVAF) and for the treatment of deep vein thrombosis (DVT) and pulmonary embolism ... Edoxaban is a member of the Novel Oral Anti-Coagulants (NOACs) class of drugs, and is a rapidly acting …
Matched Categories: … Blood and Blood Forming Organs …
Matched Products: … LIXIANA FILM-COATED TABLET 30 MG ... LIXIANA FILM-COATED TABLET 60 MG ... LIXIANA FILM-COATED TABLET 15 MG …

Ambrisentan

Ambrisentan is an orally active selective type A endothelin receptor antagonist indicated for the treatment of pulmonary arterial hypertension. It is approved in Europe, Canada and the United States for use as a single agent to improve exercise ability and delay clinical worsening. In addition, it is approved in the...
Approved
Investigational
Matched Description: … ability and delay clinical worsening. ... It is approved in Europe, Canada and the United States for use as a single agent to improve exercise ... States for use in combination with tadalafil to reduce the risks of disease progression, hospitalization and …
Matched Categories: … ambrisentan and tadalafil …
Matched Products: … VOLIBRIS 10 MG FILM COATED TABLET ... VOLIBRIS FILM-COATED TABLET 5MG ... VOLIBRIS FILM-COATED TABLET 10 MG …

Clopidogrel

Clopidogrel is a prodrug of a platelet inhibitor used to reduce the risk of myocardial infarction and stroke.[A180508,L7213] Clopidogrel is indicated to reduce the risk of myocardial infarction for patients with non-ST elevated acute coronary syndrome (ACS), patients with ST-elevated myocardial infarction, and in recent MI, stroke, or established peripheral...
Approved
Matched Description: … Clopidogrel is a prodrug of a platelet inhibitor used to reduce the risk of myocardial infarction and ... with non-ST elevated acute coronary syndrome (ACS), patients with ST-elevated myocardial infarction, and ... be superior to [aspirin] in reducing cardiovascular outcomes in patients with cardiovascular disease and …
Matched Mixtures name: … CoPlavix Film-Coated Tablet 75 mg/100 mg ... CoPlavix 75/100mg Film-Coated Tablet …
Matched Categories: … Blood and Blood Forming Organs …
Matched Products: … Mar-clopidogrel ... Plavix Film-Coated Tablet 300 mg ... MYOCLIP FILM COATED TABLET 75MG …

Pirfenidone

Pirfenidone is a synthetic pyridone drug. It is an antifibrotic agent with anti-inflammatory and antioxidant properties that is used to treat idiopathic pulmonary fibrosis (IPF), which is a chronic, progressive form of interstitial pneumonia. While its mechanism of action is not yet fully understood, pirfenidone is proposed to primarily regulate...
Approved
Investigational
Matched Description: … [A251370] It is an antifibrotic agent with anti-inflammatory and antioxidant properties [A251370] that ... fully understood, pirfenidone is proposed to primarily regulate tumor necrosis factor (TNF) pathways and …
Matched Categories: … Antineoplastic and Immunomodulating Agents …
Matched Products: … ESBRIET FILM COATED TABLET 267MG ... ESBRIET FILM COATED TABLET 801MG ... ESBRIET (FILM-COATED TABLETS 267 MG) …

Cinacalcet

Cinacalcet is a calcimimetic sold by Amgen under the trade name Sensipar® in North America and Australia and as Mimpara® in Europe. It is used to treat hyperparathyroidism due to parathyroid tumours or renal failure.
Approved
Matched Description: … and as Mimpara® in Europe. ... Cinacalcet is a calcimimetic sold by Amgen under the trade name Sensipar® in North America and Australia …
Matched Categories: … Calcium-Regulating Hormones and Agents ... Sex Hormones and Insulins ... Hormones, Hormone Substitutes, and Hormone Antagonists ... Calcium Homeostasis ... Calcium-sensing Receptor Agonist …
Matched Products: … Mar-cinacalcet ... CİNESET 90 MG FİLM TABLET, 28 ADET ... CALCELAR 25mg Film Coated Tablet …

Colesevelam

Colesevelam is a bile acid sequestrant. Colesevelam is used with exercise and diet changes (restriction of cholesterol and fat intake) to reduce the amount of cholesterol and certain fatty substances in the blood. It works by binding bile acids in the intestine. Bile acids are made when cholesterol is broken...
Approved
Matched Description: … Colesevelam is used with exercise and diet changes (restriction of cholesterol and fat intake) to reduce ... the amount of cholesterol and certain fatty substances in the blood. …
Matched Products: … ZENUM 625 MG FILM TABLET, 180 ADET ... SARTOL 625 MG FİLM TABLET, 60 TABLET ... KOVEL 625 MG FİLM KAPLI TABLET, 30 ADET …

Vorapaxar

Vorapaxar is a tricyclic himbacine-derived selective inhibitor of protease activated receptor (PAR-1) indicated for reducing the incidence of thrombotic cardiovascular events in patients with a history of myocardial infarction (MI) or with peripheral arterial disease (PAD). By inhibiting PAR-1, a thrombin receptor expressed on platelets, vorapaxar prevents thrombin-related platelet aggregation.
Approved
Matched Synonyms: … 9aS)-9-{(E)-2-[5-(3-Fluorophényl)-2-pyridinyl]vinyl}-1-méthyl-3-oxododécahydronaphto[2,3-c]furan-6-yl]carbamate ... fluorophenyl)-2-pyridyl]vinyl]-3-methyl-1-oxo-3a,4,4a,5,6,7,8,8a,9,9a-decahydro-3H-benzo[f]isobenzofuran-7-yl]carbamate …
Matched Iupac: … [(1E)-2-[5-(3-fluorophenyl)pyridin-2-yl]ethenyl]-1-methyl-3-oxo-dodecahydronaphtho[2,3-c]furan-6-yl]carbamate …
Matched Categories: … Blood and Blood Forming Organs …

Etodolac

Etodolac is a non-steroidal anti-inflammatory drug (NSAID) with anti-inflammatory, analgesic and antipyretic properties. Its therapeutic effects are due to its ability to inhibit prostaglandin synthesis. It is indicated for relief of signs and symptoms of rheumatoid arthritis and osteoarthritis.
Approved
Investigational
Vet approved
Matched Description: … It is indicated for relief of signs and symptoms of rheumatoid arthritis and osteoarthritis. ... Etodolac is a non-steroidal anti-inflammatory drug (NSAID) with anti-inflammatory, analgesic and antipyretic …
Matched Mixtures name: … ETOTİO 400MG/8MG FİLM KAPLI TABLET, FİLM TABLET, 14 ADET ... ETOTIO 400 MG/8 MG FILM TABLET, 20 ADET ... ETOFAM 400MG/20MG FİLM KAPLI TABLET, 20 ADET …
Matched Categories: … Acetic Acid Derivatives and Related Substances ... Antiinflammatory and Antirheumatic Products ... Antiinflammatory and Antirheumatic Products, Non-Steroids …
Matched Products: … BARCA 500 MG FILM TABLET, 14 ADET ... CIRRINAL 200 MG FILM TABLET, 20 ADET ... EDOLAR 600 MG FILM TABLET, 10 ADET …

Gemifloxacin

Gemifloxacin is a quinolone antibacterial agent with a broad-spectrum activity that is used in the treatment of acute bacterial exacerbation of chronic bronchitis and mild-to-moderate pneumonia. It is available in oral formulations. Gemifloxacin acts by inhibiting DNA synthesis through the inhibition of both DNA gyrase and topoisomerase IV, which are...
Approved
Investigational
Matched Description: … broad-spectrum activity that is used in the treatment of acute bacterial exacerbation of chronic bronchitis and ... Gemifloxacin acts by inhibiting DNA synthesis through the inhibition of both DNA gyrase and topoisomerase …
Matched Products: … Factive film-coated tablet 320 mg ... ONFACT 320 MG FİLM TABLET, 5 ADET ... ONFACT 320 MG FİLM TABLET, 7 ADET …

Cefdinir

Cefdinir, also known as Omnicef, is a semi-synthetic, broad-spectrum antibiotic belonging to the third generation of the cephalosporin class. It has been proven to be effective for the treatment of common bacterial infections in the ear, sinus, throat, lungs, and skin. Cefdinir was approved by the FDA in 1997 to...
Approved
Matched Description: … to be effective for the treatment of common bacterial infections in the ear, sinus, throat, lungs, and ... Cefdinir was approved by the FDA in 1997 to treat a variety of mild to moderate infections and was initially …
Matched Mixtures name: … CEFBIR PLUS 300/125 MG FILM KAPLI TABLET, 20 ADET ... FULLCEF PLUS 300/125 MG FILM KAPLI TABLET, 20 ADET …
Matched Products: … ASEMAX 300 MG FILM TABLET, 14 ADET ... ASEMAX 600 MG FILM KAPLI TABLET, 14 ADET ... ASEMAX 600 MG FILM KAPLI TABLET ,10 TABLET …

Brivaracetam

Brivaracetam is a racetam derivative of levetiracetam used in the treatment of partial-onset seizures. Brivaracetam binds SV2A with 20 times higher affinity than levetiracetam . It is available under the brand name Briviact made by UCB. Briviact received FDA approval on February 19, 2016 .
Approved
Investigational
Matched Products: … BRIVIACT 10 MG FILM KAPLI TABLET ,14 FILM KAPLI TABLET ... BRIVIACT 10 MG FILM KAPLI TABLET ,168 FILM KAPLI TABLET ... BRIVIACT 10 MG FILM KAPLI TABLET ,56 FILM KAPLI TABLET …

Selexipag

Selexipag was approved by the United States FDA on December 22, 2015 for the treatment of pulmonary arterial hypertension (PAH) to delay disease progression and reduce risk of hospitalization. PAH is a relatively rare disease with usually a poor prognosis requiring more treatment options to prolong long-term outcomes. Marketed by...
Approved
Matched Description: … December 22, 2015 for the treatment of pulmonary arterial hypertension (PAH) to delay disease progression and ... Marketed by Actelion Pharmaceuticals under brand name Uptravi, selexipag and its active metabolite, ACT ... act as agonists of the prostacyclin receptor to increase vasodilation in the pulmonary circulation and …
Matched Categories: … Blood and Blood Forming Organs …
Matched Products: … Uptravi 200 microgram Film-coated tablets ... UPTRAVI FILM-COATED TABLET 200MCG ... UPTRAVI FILM-COATED TABLETS 400MCG …

Bosentan

Bosentan is a dual endothelin receptor antagonist marketed under the trade name Tracleer by Actelion Pharmaceuticals. Bosentan is used to treat pulmonary hypertension by blocking the action of endothelin molecules that would otherwise promote narrowing of the blood vessels and lead to high blood pressure.
Approved
Investigational
Matched Description: … blocking the action of endothelin molecules that would otherwise promote narrowing of the blood vessels and …
Matched Categories: … Genito Urinary System and Sex Hormones ... Gynecological Antiinfectives and Antiseptics …
Matched Products: … Mar-bosentan ... PROART FILM COATED TABLETS 125MG ... CLOKSAR 125 MG FILM TABLET, 56 TABLET …

Tofacitinib

Tofacitinib is an inhibitor of Janus kinases, a group of intracellular enzymes involved in signalling pathways that affect hematopoiesis and immune cell function. It is approved by the FDA for treatment of moderate to severe rheumatoid arthritis that responds inadequately to methotrexate or in those who are intolerant to methotrexate....
Approved
Investigational
Matched Description: … Known adverse effects include nausea and headache as well as more serious immunologic and hematological ... kinases, a group of intracellular enzymes involved in signalling pathways that affect hematopoiesis and ... tofacitinib has also been studied in clinical trials for the prevention of organ transplant rejection, and …
Matched Categories: … Antineoplastic and Immunomodulating Agents …
Matched Products: … Xeljanz Film-Coated Tablets 5mg ... JANTY 5 MG FİLM KAPLI TABLET, 56 ADET ... TOFİK 5 MG FİLM KAPLI TABLET, 56 ADET …

Vortioxetine

Vortioxetine is an antidepressant medication indicated for the treatment of major depressive disorder (MDD). It is classified as a serotonin modulator and stimulator (SMS) as it has a multimodal mechanism of action towards the serotonin neurotransmitter system whereby it simultaneously modulates one or more serotonin receptors and inhibits the reuptake...
Approved
Investigational
Matched Description: … an antagonist of the 5-HT3, 5-HT1D, and 5-HT7 receptors. ... It is classified as a serotonin modulator and stimulator (SMS) as it has a multimodal mechanism of action ... serotonin neurotransmitter system whereby it simultaneously modulates one or more serotonin receptors and …
Matched Products: … Brintellix 5mg film-coated tablets ... Brintellix 15mg Film-coated Tablets ... Brintellix 20mg Film-coated Tablets …

Oxcarbazepine

Oxcarbazepine is an anti-epileptic medication used in the treatment of partial onset seizures that was first approved for use in the United States in 2000.[L8627,L8630,L8633] It is a structural derivative of carbamazepine and exerts a majority of its activity via a pharmacologically active metabolite, MHD, which exists as a racemate...
Approved
Matched Description: … [L8627,L8630,L8633] It is a structural derivative of [carbamazepine][A186101] and exerts a majority of …
Matched Categories: … Metabolic Side Effects of Drugs and Substances …
Matched Products: … OXCARIL 150 MG FILM TABLET, 50 ADET ... OXCARIL 300 MG FILM TABLET, 50 ADET ... OXCARIL 600 MG FILM TABLET, 50 ADET …

Olmesartan

Olmesartan belongs to the angiotensin II receptor blocker (ARB) family of drugs, which also includes telmisartan, candesartan, losartan, valsartan, and irbesartan. ARBs selectively bind to angiotensin receptor 1 (AT1) and prevent the protein angiotensin II from binding and exerting its hypertensive effects, which include vasoconstriction, stimulation and synthesis of aldosterone...
Approved
Investigational
Matched Description: … and exerting its hypertensive effects, which include vasoconstriction, stimulation and synthesis of ... aldosterone and ADH, cardiac stimulation, and renal reabsorption of sodium, among others. ... blocker (ARB) family of drugs, which also includes [telmisartan], [candesartan], [losartan], [valsartan], and …
Matched Mixtures name: … Amlodipine and olmesartan Medoxomil ... Amlodipine and olmesartan Medoxomil ... Amlodipine and olmesartan Medoxomil …
Matched Categories: … Angiotensin II Antagonists and Calcium Channel Blockers ... Angiotensin II receptor blockers (ARBs) and calcium channel blockers ... Angiotensin II receptor blockers (ARBs) and diuretics ... olmesartan medoxomil and diuretics ... olmesartan medoxomil and amlodipine …
Matched Products: … OMETAN 5 MG FILM TABLET,FILM TABLET, 28 ADET ... OMETAN 5 MG FILM TABLET,FILM TABLET, 84 ADET ... OMETAN 10 MG FILM TABLET,FILM TABLET, 28 ADET …

Palbociclib

Palbociclib is a piperazine pyridopyrimidine that acts in the cell cycle machinery. It is a second generation cyclin-dependent kinase inhibitor selected from a group of pyridopyrimidine compounds due to its favorable physical and pharmaceutical properties. Palbociclib was developed by Pfizer Inc after the discovery that identified the cyclin-dependent kinases as...
Approved
Investigational
Matched Description: … based on findings from postmarketing reports and electronic health records demonstrating safety and ... inhibitor[A176798] selected from a group of pyridopyrimidine compounds due to its favorable physical and ... advanced or metastatic breast cancer and its indications were updated in April 2019 to include male patients …
Matched Categories: … Antineoplastic and Immunomodulating Agents …
Matched Products: … IBRANCE FILM COATED TABLET 75MG ... IBRANCE FILM COATED TABLET 100MG ... IBRANCE FILM COATED TABLET 125MG …

Tadalafil

Tadalafil is a selective phosphodiesterase-5 inhibitor that is used in the treatment of erectile dysfunction (ED), pulmonary arterial hypertension (PAH), and benign prostatic hypertrophy.[L39100, L39105] It was first approved in 2003 by the FDA for use in ED and later in 2009 for PAH. In contrast to other PDE5 inhibitors...
Approved
Investigational
Matched Description: … that is used in the treatment of erectile dysfunction (ED), pulmonary arterial hypertension (PAH), and ... [L39100, L39105] It was first approved in 2003 by the FDA for use in ED and later in 2009 for PAH. ... In contrast to other PDE5 inhibitors like [sildenafil], tadalafil has greater selectivity for PDE5 and …
Matched Mixtures name: … TADA PLUS 30/20 MG FILM KAPLI TABLET ,4 ADET ... TADA PLUS 30/20 MG FILM KAPLI TABLET ,8 ADET …
Matched Categories: … Genito Urinary System and Sex Hormones ... ambrisentan and tadalafil ... tamsulosin and tadalafil ... finasteride and tadalafil ... macitentan and tadalafil …
Matched Products: … Mar-tadalafil ... MYESED 10MG FILM KAPLI TABLET ,2 FILM TABLET ... MYESED 10MG FILM KAPLI TABLET ,4 FILM TABLET …

Apixaban

Apixaban is an oral, direct, and highly selective factor Xa (FXa) inhibitor of both free and bound FXa, as well as prothrombinase, independent of antithrombin III for the prevention and treatment of thromboembolic diseases[Label,A6897]. It is marketed under the name Eliquis[Label,L6043]. Apixaban was approved by the FDA on December 28,...
Approved
Matched Description: … Apixaban is an oral, direct, and highly selective factor Xa (FXa) inhibitor of both free and bound FXa ... , as well as prothrombinase, independent of antithrombin III for the prevention and treatment of thromboembolic …
Matched Categories: … Blood and Blood Forming Organs …
Matched Products: … Mar-apixaban ... Eliquis 5mg film-coated tablets ... Eliquis 2.5mg film-coated tablets …

Moxifloxacin

Moxifloxacin is a synthetic fluoroquinolone antibiotic agent. Bayer AG developed the drug (initially called BAY 12-8039) and it is marketed worldwide (as the hydrochloride) under the brand name Avelox (in some countries also Avalox) for oral treatment.
Approved
Investigational
Matched Description: … Bayer AG developed the drug (initially called BAY 12-8039) and it is marketed worldwide (as the hydrochloride …
Matched Products: … Mar-moxifloxacin ... MOXICUM 400 MG FILM TABLET ,5 FILM TABLET ... MOXICUM 400 MG FILM TABLET ,FILM TABLET, 10 ADET …

Trametinib

Trametinib is an orally bioavailable mitogen-activated extracellular signal-regulated kinase 1 (MEK1) and MEK2 inhibitor.[A258298,A258293] It was first approved by the FDA in May 2013 for the treatment of melanoma. It was later approved by Health Canada on July 18, 2013 and by the European Commission on June 30, 2014. Trametinib...
Approved
Matched Description: … Trametinib is an orally bioavailable mitogen-activated extracellular signal-regulated kinase 1 (MEK1) and ... [A258298] It was later approved by Health Canada on July 18, 2013 [L45588] and by the European Commission ... currently approved to treat a variety of cancers with BRAF mutations, such as non-small cell lung cancer and …
Matched Categories: … Antineoplastic and Immunomodulating Agents …
Matched Products: … MEKINIST FILM-COATED TABLETS 2MG ... MEKINIST FILM-COATED TABLETS 0.5MG ... MEKINIST 2 MG FILM KAPLI TABLET ,7 TABLET …

2-Methyl-2-propanyl [(1R)-2-methyl-1-(1,3,4-oxadiazol-2-yl)propyl]carbamate

Experimental
Matched Name: … 2-Methyl-2-propanyl [(1R)-2-methyl-1-(1,3,4-oxadiazol-2-yl)propyl]carbamate …
Matched Iupac: … tert-butyl N-[(1R)-2-methyl-1-(1,3,4-oxadiazol-2-yl)propyl]carbamate …
Displaying drugs 926 - 950 of 1245 in total