Displaying drugs 10551 - 10575 of 12564 in total
Elzasonan
Elzasonan is under investigation in clinical trial NCT00275197 (A Research Study to Compare the Treatments of a Combination of Elzasonan With Zoloft, to Zoloft Alone, or Placebo in People With Major Depressive Disorder (MDD)).
Investigational
Matched Description: … a Combination of Elzasonan With Zoloft, to Zoloft Alone, or Placebo in People With Major Depressive ... Elzasonan is under investigation in clinical trial NCT00275197 (A Research Study to Compare the Treatments of …
NCX 1022
NCX is an NO-releasing derivative of hydrocortisone.
Investigational
Matched Description: … NCX is an NO-releasing derivative of hydrocortisone. …
Ingenol disoxate
Ingenol disoxate is under investigation in clinical trial NCT02120456 (Safety and Efficacy of Escalating Doses of LEO 43204 Applied Once Daily for Two Consecutive Days on Approximately 250 cm2 on Trunk and Extremities in Subjects With Actinic Keratosis).
Investigational
Matched Description: … Ingenol disoxate is under investigation in clinical trial NCT02120456 (Safety and Efficacy of Escalating ... Doses of LEO 43204 Applied Once Daily for Two Consecutive Days on Approximately 250 cm2 on Trunk and …
TM30339
TM30339 is an analogue of the natural hormone Pancreatic Polypeptide (PP), which is released in connection with meals. TM30339 works through the same receptor as the natural satiety hormone, Pancreatic Polypeptide (PP), but TM30339 has improved properties compared with PP. TM30339 thus imitates a natural mechanism, a satiety signal from...
Investigational
Matched Description: … TM30339 is developed for the treatment of obesity. ... TM30339 is an analogue of the natural hormone Pancreatic Polypeptide (PP), which is released in connection ... imitates a natural mechanism, a satiety signal from the gastrointestinal system involved in the regulation of …
Nelotanserin
Nelotanserin has been used in trials studying the treatment of Lewy Body Dementia, Visual Hallucinations, Dementia With Lewy Bodies, and REM Sleep Behavior Disorder. It is a highly selective antagonist at the 5-HT2A serotonin receptor. It increases non-REM sleep, the most restorative phase of the sleep cycle, without sacrificing REM...
Investigational
Matched Description: … Nelotanserin has been used in trials studying the treatment of Lewy Body Dementia, Visual Hallucinations ... Nelotanserin works through a mechanism of action that is different from currently marketed drugs. ... It increases non-REM sleep, the most restorative phase of the sleep cycle, without sacrificing REM or …
SAR445136
SAR445136 is an investigational zinc finger nuclease gene-edited cell therapy. It consists of autologous CD34+ hematopoietic stem precursor cells (HSPC) modified ex vivo by zinc finger nucleases (ZFN) that target the BCL11A gene erythroid-specific enhancer (ESE) to increase endogenous HbF production in erythrocytes (RBC). It was formerly investigated for the...
Investigational
Matched Description: … investigated for the treatment of sickle cell disease. ... It consists of autologous CD34+ hematopoietic stem precursor cells (HSPC) modified ex vivo by zinc finger ... [A259063] It was formerly investigated for the treatment of beta-thalassemia, and it is currently being …
ASP-4058
ASP4058 has been used in trials studying Food Effect of ASP4058 and Pharmacokinetics of ASP4058.
Investigational
Matched Description: … ASP4058 has been used in trials studying Food Effect of ASP4058 and Pharmacokinetics of ASP4058. …
Afimoxifene
Afimoxifene (4-Hydroxytamoxifen, trade name TamoGel) is a new estrogen inhibitor under investigation for a variety of estrogen-dependent conditions, including cyclic breast pain and gynecomastia. TamoGel is formulated using Enhanced Hydroalcoholic Gel (EHG) Technology. This technology enables percutaneous delivery of drugs that cannot be delivered orally. It is being developed by...
Investigational
Matched Description: … This technology enables percutaneous delivery of drugs that cannot be delivered orally. ... Hydroxytamoxifen, trade name TamoGel) is a new estrogen inhibitor under investigation for a variety of …
BBV152
BBV152 is a vaccine candidate created by the Indian Council of Medical Research (ICMR). The candidate, a whole virion inactivated SARS-CoV-2 vaccine, was developed from a well-known SARS-CoV-2 strain and a vero cell platform (CCL-81) with adjuncts of either aluminum hydroxide gel (Algel) or a novel TLR7/8 agonist adsorbed gel....
Investigational
Matched Description: … The components of the vaccine include BBV152A, BBV152B, and BBV152C. ... BBV152 is a vaccine candidate created by the Indian Council of Medical Research (ICMR). ... , was developed from a well-known SARS-CoV-2 strain and a vero cell platform (CCL-81) with adjuncts of …
Equilenin
Equilenin is an estrogenic steroid produced by horses. It has a total of five double bonds in the A- and B-ring. High concentration of equilenin is found in the urine of pregnant mares.
Experimental
Matched Description: … High concentration of equilenin is found in the urine of pregnant mares. ... It has a total of five double bonds in the A- and B-ring. …
NX-1207
NX-1207 is an investigational new drug for BPH, whose chemical entity and mechanism of action remain undisclosed. Nymox Pharmaceutical Corporation recently completed studies of NX-1207 for treatment of benign prostatic hyperplasia (BPH).
Investigational
Matched Description: … Nymox Pharmaceutical Corporation recently completed studies of NX-1207 for treatment of benign prostatic ... NX-1207 is an investigational new drug for BPH, whose chemical entity and mechanism of action remain …
Gevokizumab
Gevokizumab has been used in trials studying the treatment of Acne Vulgaris, Osteoarthritis, Behcet's Uveitis, Pyoderma Gangrenosum, and Behcet's Disease Uveitis, among others. Gevokizumab acts as a modulator of cytokine imbalance in IL-1 mediated disease states. It has a very high binding affinity of 300fM and blocks the activation of...
Investigational
Matched Description: … It has a very high binding affinity of 300fM and blocks the activation of IL-1 receptors. ... Gevokizumab acts as a modulator of cytokine imbalance in IL-1 mediated disease states. ... Gevokizumab has been used in trials studying the treatment of Acne Vulgaris, Osteoarthritis, Behcet's …
Corticorelin
Corticotropin-releasing factor is studied in the treatment of brain cancer. It is made naturally by the hypothalamus (a part of the brain) and can also be made in the laboratory. Human corticotropin-releasing factor may help reduce symptoms caused by edema (swelling) of the brain. It is a type of neurohormone,...
Investigational
Matched Description: … It is a type of neurohormone, also called hCRF. ... Corticotropin-releasing factor is studied in the treatment of brain cancer. ... It is made naturally by the hypothalamus (a part of the brain) and can also be made in the laboratory …
CDP323
CDP323 is an antagonist of the vascular cell adhesion molecule 1 (VCAM-1) binding to alpha4-integrins (other adhesion molecules), a process thought to be implicated in the pathophysiology of Multiple Sclerosis (MS). It is considered a small-molecule prodrug. CDP323 was originally developed by the British biopharmaceutical company Celltech plc. (now UCB...
Investigational
Matched Description: … (now UCB S.A.) and is a putative new drug for oral treatment of multiple sclerosis. ... CDP323 is an antagonist of the _vascular cell adhesion molecule 1_ (VCAM-1) binding to alpha4-integrins ... (other adhesion molecules), a process thought to be implicated in the pathophysiology of Multiple Sclerosis …
Orgotein
Superoxide is a natural byproduct of oxygen metabolism which, if left unchecked, leads to cell damage. Superoxide dismutase (SOD) is an enzyme that alternately catalyzes the dismutation of the superoxide radical into either the less damaging hydrogen peroxide or molecular oxygen. Hydrogen peroxide can be degraded by catalase. The antioxidant...
Investigational
Vet approved
Matched Description: … The antioxidant mechanism of SOD is common to most organisms exposed to oxygen. ... Superoxide is a natural byproduct of oxygen metabolism which, if left unchecked, leads to cell damage ... Superoxide dismutase (SOD) is an enzyme that alternately catalyzes the dismutation of the superoxide …
ChulaCov19 mRNA vaccine
The ChulaCov19 vaccine is mRNA-based and was developed in Thailand’s Chulalongkorn University in collaboration with the University of Pennsylvania in the US[L30673, L30678]. Pre-clinical studies in mice and monkeys showed evidence that the vaccine facilitates an impressive generation of neutralizing antibodies . The next phase of this study is for...
Investigational
Matched Description: … mRNA-based and was developed in Thailand’s Chulalongkorn University in collaboration with the University of ... The next phase of this study is for phase I and II clinical trials (NCT04566276) beginning in January ... Pre-clinical studies in mice and monkeys showed evidence that the vaccine facilitates an impressive generation of …
Navarixin
Navarixin has been investigated for the treatment of Asthma.
Investigational
Matched Description: … Navarixin has been investigated for the treatment of Asthma. …
Vestipitant
Vestipitant has been investigated for the treatment of Tinnitus.
Investigational
Matched Description: … Vestipitant has been investigated for the treatment of Tinnitus. …
Ferric oxyhydroxide
An antiferromagnetic material; constitutes the core of natural ferritin.
Experimental
Matched Description: … An antiferromagnetic material; constitutes the core of natural ferritin. …
Natural Killer Cell
Natural Killer (NK) cells originate and differentiate from hematopoietic stem cells through various signalling pathways involving cytokines and interleukins. These cells arise from CD34+ lymphoid progenitors and comprise 10-15% of all lymphocytes in human peripheral blood. Once completely differentiated, NK cells lack B (CD19-) and T(CD3-) lymphocyte markers and carry...
Investigational
Matched Description: … Expansion involves the use of feeder cell line systems or bioreactors to enhance the number of NK cells ... The most standard and utilized source of NK cells is directly from the peripheral blood of a donor through ... of toxic chemicals and cytokine secretion, respectively. …
HPV-16 trojan peptide vaccine
HPV-16 trojan peptide vaccine is an investigational cancer immunotherapy consisting of a novel Trojan peptide complex, composed of human papilloma virus 16 (HPV 16) epitopes, to stimulate antigen-specific CD4 and CD8 T cell responses.
Investigational
Matched Description: … HPV-16 trojan peptide vaccine is an investigational cancer immunotherapy consisting of a novel Trojan ... peptide complex, composed of human papilloma virus 16 (HPV 16) epitopes, to stimulate antigen-specific …
Custirsen
Custirsen is a benzopyran with potential antineoplastic activity. Custirsen acts as a selective estrogen receptor modulator (SERM), inhibiting the proliferation of estrogen-sensitive breast cancer cells. This agent also inhibits growth and induces apoptosis of glioblastoma cells via a mechanism independent of estrogen receptor-related mechanisms. Custirsen is also being investigated in...
Investigational
Matched Description: … of estrogen receptor-related mechanisms. ... Custirsen is also being investigated in the treatment of primary brain tumors. ... This agent also inhibits growth and induces apoptosis of glioblastoma cells via a mechanism independent …
IDM-1
IDM-1 is IDM’s most advanced antibody-based Cell drug for the treatment of cancer. It is comprised of MAK(Monocytes-derived Activated Killer) cells associated with MDX-210, a bispecific anti-HER-2/neu antibody developed by Medarex Inc.
Investigational
Matched Description: … IDM-1 is IDM’s most advanced antibody-based Cell drug for the treatment of cancer. ... It is comprised of MAK(Monocytes-derived Activated Killer) cells associated with MDX-210, a bispecific …
CERE-110
CERE-110 is a gene-therapy product that involves in vivo delivery of nerve growth factor (NGF) genes through an adeno-associated viral vector (AAV) delivery system. This drug is developed by Ceregene and currently under phase I of clinical trial.
Investigational
Matched Description: … This drug is developed by Ceregene and currently under phase I of clinical trial. ... CERE-110 is a gene-therapy product that involves in vivo delivery of nerve growth factor (NGF) genes …
Nitenpyram
Nitenpyram is an insecticide used in agriculture and veterinary medicine to kill external parasites of pets. It is a neonicotinoid, a neurotoxin that blocks neural messages and binds particularly tightly in the central nervous system of insects, causing rapid death.
Experimental
Vet approved
Matched Description: … Nitenpyram is an insecticide used in agriculture and veterinary medicine to kill external parasites of ... neurotoxin that blocks neural messages and binds particularly tightly in the central nervous system of …
Displaying drugs 10551 - 10575 of 12564 in total