Displaying drugs 10626 - 10650 of 12589 in total
IGN301
IGN301 is a cancer vaccine based on an anti-idiotypic antibody which provokes an immune response to Lewis Y. Lewis Y is a carbohydrate molecule expressed on the surface of tumor cells of epithelial origin (e.g. lung, intestinal, breast, prostate or ovarian cancers).
Investigational
Matched Description: … Lewis Y is a carbohydrate molecule expressed on the surface of tumor cells of epithelial origin (e.g. …
Thalagen
Thalagen is a branded product developed by San Rocco Therapeutics. It consists of autologous CD34-positive hematopoietic progenitor cells transduced with TNS9.3.55, a lentiviral vector encoding the normal human beta-globin gene. It is being investigated for the treatment of beta-thalassemia.
Investigational
Matched Description: … It is being investigated for the treatment of beta-thalassemia.[L46168] ... It consists of autologous CD34-positive hematopoietic progenitor cells transduced with TNS9.3.55, a lentiviral …
PX-12
PX-12 (1-methylpropyl 2-imidazolyl disulfide) is a small-molecule inhibitor of Trx-1 (thioredoxin-1), stimulates apoptosis, down-regulates HIF-1α and vascular endothelial growth factor (VEGF) and inhibits tumor growth in animal models. Since high levels of Trx-1 have been associated with colorectal, gastric and lung cancers, PX-12 is indicated as a potential cancer treatment...
Investigational
Matched Description: … Initial trials correlated doses of Px-12 with increased patient survival. ... PX-12 (1-methylpropyl 2-imidazolyl disulfide) is a small-molecule inhibitor of Trx-1 (thioredoxin-1), ... Since high levels of Trx-1 have been associated with colorectal, gastric and lung cancers, PX-12 is indicated …
Carphenazine
Carphenazine is an antipsychotic drug, used in hospitalized patients in the management of chronic schizophrenic psychoses.
Withdrawn
Matched Description: … Carphenazine is an antipsychotic drug, used in hospitalized patients in the management of chronic schizophrenic …
Bifeprunox
Bifeprunox is a novel atypical antipsychotic agent which, along with SLV313, aripiprazole and SSR-181507 combines minimal D2 receptor agonism with 5-HT receptor agonism.
Investigational
Lucanthone
One of the schistosomicides, it has been replaced largely by hycanthone and more recently praziquantel. (From Martindale The Extrapharmacopoeia, 30th ed., p46). It is currently being tested as a radiation sensitizer.
Investigational
Matched Description: … One of the schistosomicides, it has been replaced largely by hycanthone and more recently praziquantel …
NX-1207
NX-1207 is an investigational new drug for BPH, whose chemical entity and mechanism of action remain undisclosed. Nymox Pharmaceutical Corporation recently completed studies of NX-1207 for treatment of benign prostatic hyperplasia (BPH).
Investigational
Matched Description: … Nymox Pharmaceutical Corporation recently completed studies of NX-1207 for treatment of benign prostatic ... NX-1207 is an investigational new drug for BPH, whose chemical entity and mechanism of action remain …
AeroLEF
AeroLEF™ (aerosolized liposome-encapsulated fentanyl) is a novel, proprietary inhalation formulation of free and liposome-encapsulated fentanyl intended to provide rapid, extended and personalized analgesia for patients experiencing acute pain episodes. AeroLEF™ is in development for the treatment of moderate to severe pain, including cancer pain.
Investigational
Matched Description: … AeroLEF™ (aerosolized liposome-encapsulated fentanyl) is a novel, proprietary inhalation formulation of ... AeroLEF™ is in development for the treatment of moderate to severe pain, including cancer pain. …
INCB7839
INCB7839 is a novel, orally available ADAM metalloprotease inhibitor that is designed to block activation of the epidermal growth factor (EGFR) pathways. It represents a potentially important new class of targeted breast cancer therapy. It has shown promising clinical activity in heavily pretreated, refractory breast cancer patients.
Investigational
Matched Description: … It represents a potentially important new class of targeted breast cancer therapy. ... INCB7839 is a novel, orally available ADAM metalloprotease inhibitor that is designed to block activation of …
Neovastat
Neovastat is a naturally occurring anti-angiogenic compound, extracted from cartilage, with multiple anti-angiogenic mechanisms of action that provide broad therapeutic potential for a number of diseases. It is currently in international Phase III trials for renal cell carcinoma and non-small-cell lung cancer.
Investigational
Matched Description: … action that provide broad therapeutic potential for a number of diseases. ... occurring anti-angiogenic compound, extracted from cartilage, with multiple anti-angiogenic mechanisms of …
QRX-411
QRX-411 is a first-in-class RNA-based oligonucleotide designed to restore wild-type USH2A mRNA, leading to the production of the functional USH2A protein. It addresses the underlying cause of Usher syndrome due to the c.7595-2144A>G mutation in the USH2A gene.
Investigational
Matched Description: … It addresses the underlying cause of Usher syndrome due to the c.7595-2144A>G mutation in the _USH2A_ ... first-in-class RNA-based oligonucleotide designed to restore wild-type USH2A mRNA, leading to the production of …
EA-2353
EA-2353 is a small molecule inhibitor of kinase mediators of the Wnt pathway.
Investigational
Matched Description: … EA-2353 is a small molecule inhibitor of kinase mediators of the Wnt pathway. …
Otilimab
Investigated for the treatment of osteoarthritis and rheumatoid arthritis (RA).
Investigational
Matched Description: … Investigated for the treatment of osteoarthritis and rheumatoid arthritis (RA). …
Visilizumab
Visilizumab has been investigated for the treatment of Ulcerative Colitis.
Investigational
Matched Description: … Visilizumab has been investigated for the treatment of Ulcerative Colitis. …
Mavrilimumab
Mavrilimumab has been investigated for the treatment of Rheumatoid Arthritis.
Investigational
Matched Description: … Mavrilimumab has been investigated for the treatment of Rheumatoid Arthritis. …
Doxifluridine
Doxifluridine has been investigated for the treatment of Stomach Cancer.
Investigational
Matched Description: … Doxifluridine has been investigated for the treatment of Stomach Cancer. …
Serlopitant
Serlopitant has been investigated for the treatment of Prurigo Nodularis.
Investigational
Matched Description: … Serlopitant has been investigated for the treatment of Prurigo Nodularis. …
Diclofop-methyl
Herbicide for control of wild oat & foxtails in cereal crops.
Experimental
Matched Description: … Herbicide for control of wild oat & foxtails in cereal crops. …
GFH-925
GFH-925 is an irreversibly covalent inhibitor of KRAS G12C.
Investigational
Matched Description: … GFH-925 is an irreversibly covalent inhibitor of KRAS G12C. …
Equilenin
Equilenin is an estrogenic steroid produced by horses. It has a total of five double bonds in the A- and B-ring. High concentration of equilenin is found in the urine of pregnant mares.
Experimental
Matched Description: … High concentration of equilenin is found in the urine of pregnant mares. ... It has a total of five double bonds in the A- and B-ring. …
Aniline
Aniline, phenylamine or aminobenzene is an organic compound with the formula C6H5NH2. Consisting of an amine attached to a benzene ring, aniline is the prototypical aromatic amine. Being a precursor to many industrial chemicals, its main use is in the manufacture of precursors to polyurethane. Like most volatile amines, it...
Experimental
Matched Description: … Like most volatile amines, it possesses the somewhat unpleasant odour of rotten fish. ... Consisting of an amine attached to a benzene ring, aniline is the prototypical aromatic amine. ... Being a precursor to many industrial chemicals, its main use is in the manufacture of precursors to polyurethane …
Gevokizumab
Gevokizumab has been used in trials studying the treatment of Acne Vulgaris, Osteoarthritis, Behcet's Uveitis, Pyoderma Gangrenosum, and Behcet's Disease Uveitis, among others. Gevokizumab acts as a modulator of cytokine imbalance in IL-1 mediated disease states. It has a very high binding affinity of 300fM and blocks the activation of...
Investigational
Matched Description: … It has a very high binding affinity of 300fM and blocks the activation of IL-1 receptors. ... Gevokizumab acts as a modulator of cytokine imbalance in IL-1 mediated disease states. ... Gevokizumab has been used in trials studying the treatment of Acne Vulgaris, Osteoarthritis, Behcet's …
Corticorelin
Corticotropin-releasing factor is studied in the treatment of brain cancer. It is made naturally by the hypothalamus (a part of the brain) and can also be made in the laboratory. Human corticotropin-releasing factor may help reduce symptoms caused by edema (swelling) of the brain. It is a type of neurohormone,...
Investigational
Matched Description: … It is a type of neurohormone, also called hCRF. ... Corticotropin-releasing factor is studied in the treatment of brain cancer. ... It is made naturally by the hypothalamus (a part of the brain) and can also be made in the laboratory …
Methaqualone
Methaqualone is a sedative-hypnotic drug that is similar in effect to barbiturates, a general central nervous system depressant. The sedative-hypnotic activity was first noted by Indian researchers in the 1950s and in 1962 methaqualone itself was patented in the US by Wallace and Tiernan. Its use peaked in the early...
Illicit
Withdrawn
Isopropyl beta-D-thiogalactopyranoside
A non-metabolizable galactose analog that induces expression of the LAC operon.
Experimental
Matched Description: … A non-metabolizable galactose analog that induces expression of the LAC operon. …
Displaying drugs 10626 - 10650 of 12589 in total