Displaying drugs 1051 - 1075 of 1145 in total
Idursulfase beta
Idursulfase beta is under investigation in clinical trial NCT01645189 (Safety and Efficacy of Hunterase).
Investigational
Matched Synonyms: … Iduronate 2-sulfatase (a-l-iduronate sulfate sulfatase), human proenzyme produced in cho cells (glycoform …
Matched Description: … Idursulfase beta is under investigation in clinical trial NCT01645189 (Safety and Efficacy of Hunterase …
Matched Categories: … Enzymes and Coenzymes ... Alimentary Tract and Metabolism …
Matched Description: … Idursulfase beta is under investigation in clinical trial NCT01645189 (Safety and Efficacy of Hunterase …
Matched Categories: … Enzymes and Coenzymes ... Alimentary Tract and Metabolism …
FB-825
FB-825 is an investigational humanized monoclonal antibody that targets the CεmX domain of the membrane-bound IgE (mIgE), causing a depletion of mIgE positive B-cells. It is currently being investigated for immune disorders, such as atopic dermatitis and hyperimmunoglobulin E syndrome (HIES).[A258448,L45743]
Investigational
Matched Synonyms: … Recombinant humanized immunoglobulin gamma 1 monoclonal antibody (mAb) directed against the CemX segment of human …
Matched Description: … It is currently being investigated for immune disorders, such as atopic dermatitis and hyperimmunoglobulin …
Matched Description: … It is currently being investigated for immune disorders, such as atopic dermatitis and hyperimmunoglobulin …
AAV2/8.TBG.hARSB
Investigational
Matched Synonyms: … serotype 8 with liver-specific thyroxinebinding globulin (TBG) promoter driving the expression of the human …
Teduglutide
Teduglutide is a glucagon-like peptide-2 (GLP-2) analogue. It is made up of 33 amino acids and is manufactured using a strain of Escherichia coli modified by recombinant DNA technology. Teduglutide differs from GLP-2 by one amino acid (alanine is substituted by glycine). The significance of this substitution is that teduglutide...
Approved
Matched Synonyms: … Glucagon-like peptide II (2-glycine) (human) …
Matched Description: … It is made up of 33 amino acids and is manufactured using a strain of Escherichia coli modified by recombinant …
Matched Categories: … Alimentary Tract and Metabolism ... Amino Acids, Peptides, and Proteins ... Various Alimentary Tract and Metabolism Products ... Hormones, Hormone Substitutes, and Hormone Antagonists …
Matched Description: … It is made up of 33 amino acids and is manufactured using a strain of Escherichia coli modified by recombinant …
Matched Categories: … Alimentary Tract and Metabolism ... Amino Acids, Peptides, and Proteins ... Various Alimentary Tract and Metabolism Products ... Hormones, Hormone Substitutes, and Hormone Antagonists …
AVR-RD-04
AVR-RD-04 is an investigational gene therapy for cystinosis. It consists of autologous CD34+ enriched cells transduced with a lentiviral vector containing RNA resulting in codon-optimized cDNA encoding for functional human cystinosin.
Investigational
Matched Synonyms: … transduced with a lentiviral vector containing RNA resulting in codon-optimized cDNA encoding for functional human …
Matched Description: … transduced with a lentiviral vector containing RNA resulting in codon-optimized cDNA encoding for functional human …
Matched Description: … transduced with a lentiviral vector containing RNA resulting in codon-optimized cDNA encoding for functional human …
Arcitumomab
Investigational
Matched Synonyms: … -chain anti-human antigen cea), disulfide with mouse monoclonal immu-4 light chain ... -chain anti-human antigen cea), disulphide with mouse monoclonal immu-4 light chain …
Matched Categories: … Amino Acids, Peptides, and Proteins …
Matched Categories: … Amino Acids, Peptides, and Proteins …
Cosfroviximab
Investigational
Matched Synonyms: … musculus monoclonal c13c6-fr1 heavy chain), disulfide with human-mus musculus monoclonal c13c6-fr1 . ... Immunoglobulin g1, anti-(ebolavirus/reston ebolavirus/sudan ebolavirus/tai forest ebolavirus glycoprotein) (human-mus …
Ongericimab
Ongericimab is under investigation in clinical trial NCT05325203 (A Study to Evaluate the Efficacy and Safety of JS002 in Patients With Heterozygous Familial Hypercholesterolemia (Hefh).).
Investigational
Matched Synonyms: … ), disulfide with human monoclonal js002 .kappa. ... Immunoglobulin g4, anti-(neural apoptosis-regulated convertase 1) (human monoclonal js002 .gamma.4-chain …
Matched Description: … Ongericimab is under investigation in clinical trial NCT05325203 (A Study to Evaluate the Efficacy and …
Matched Description: … Ongericimab is under investigation in clinical trial NCT05325203 (A Study to Evaluate the Efficacy and …
Anselamimab
Investigational
Matched Synonyms: … Immunoglobulin g1, anti-(human amyloid fibril) (human-mus musculus monoclonal cael-101 .gamma.1-chain ... ), disulfide with human-mus musculus monoclonal cael-101 .kappa. …
Sabatolimab
Sabatolimab is under investigation in clinical trial NCT03946670 (A Study of MBG453 in Combination With Hypomethylating Agents in Subjects With IPSS-R Intermediate, High or Very High Risk Myelodysplastic Syndrome (MDS).).
Investigational
Matched Synonyms: … 2) (human-mus musculus monoclonal clone nvs260714 .gamma.4-chain), disulfide with human-mus musculus ... Immunoglobulin g4 (226-proline,de-c-terminal-lysine), anti-(human hepatitis virus a cellular receptor …
Matched Categories: … Amino Acids, Peptides, and Proteins ... Antineoplastic and Immunomodulating Agents ... MONOCLONAL ANTIBODIES AND ANTIBODY DRUG CONJUGATES …
Matched Categories: … Amino Acids, Peptides, and Proteins ... Antineoplastic and Immunomodulating Agents ... MONOCLONAL ANTIBODIES AND ANTIBODY DRUG CONJUGATES …
Belzupacap Sarotalocan
Investigational
Matched Synonyms: … Human papillomavirus virus-like particles conjugated with ir700 dye au-011 …
L-3972-T
L-3972-T is one of the components of the human papilloma virus (HPV) type 16 E6/E7 synthetic long peptide (SLP) vaccine ISA101b.
Investigational
Matched Synonyms: … Human Papilloma Virus (HPV) Type 16 E6/E7 Synthetic Long Peptide (SLP) Vaccine Component L-3972-T …
Matched Description: … L-3972-T is one of the components of the human papilloma virus (HPV) type 16 E6/E7 synthetic long peptide …
Matched Description: … L-3972-T is one of the components of the human papilloma virus (HPV) type 16 E6/E7 synthetic long peptide …
Dibotermin alfa
Dibotermin alfa is a recombinant human bone morphogenetic protein-2 (rhBMP-2) derived from a recombinant Chinese Hamster Ovary (CHO) cell line [FDA Label]. It is implanted in patients undergoing bone surgeries or those with fractures. BMPs are subfamily of the transforming growth factor-β (TGF-β) superfamily that have different actions on the...
Approved
Investigational
Matched Synonyms: … Bone morphogenetic protein 2 (human recombinant rhBMP-2) …
Matched Description: … Dibotermin alfa is a recombinant human bone morphogenetic protein-2 (rhBMP-2) derived from a recombinant ... In 2004, it was approved by the FDA and is marketed as Infuse. ... critical role in the differentiation of osteoprogenitor cells into osteoblasts, thus promoting bone and …
Matched Categories: … Amino Acids, Peptides, and Proteins ... Drugs Affecting Bone Structure and Mineralization ... Intercellular Signaling Peptides and Proteins …
Matched Description: … Dibotermin alfa is a recombinant human bone morphogenetic protein-2 (rhBMP-2) derived from a recombinant ... In 2004, it was approved by the FDA and is marketed as Infuse. ... critical role in the differentiation of osteoprogenitor cells into osteoblasts, thus promoting bone and …
Matched Categories: … Amino Acids, Peptides, and Proteins ... Drugs Affecting Bone Structure and Mineralization ... Intercellular Signaling Peptides and Proteins …
WU-CART-007
WU-CART-007 consists of allogeneic, fratricide-resistant genetically modified T cells transduced with a 2nd generation 4-1BB-CD3z chimeric antigen receptor targeting human CD7.
Investigational
Matched Synonyms: … genetically modified T cell transduced with a 2nd generation 4-1BB-CD3z chimeric antigen receptor targeting human …
Matched Description: … genetically modified T cells transduced with a 2nd generation 4-1BB-CD3z chimeric antigen receptor targeting human …
Matched Description: … genetically modified T cells transduced with a 2nd generation 4-1BB-CD3z chimeric antigen receptor targeting human …
Magrolimab
Magrolimab is under investigation in clinical trial NCT02953782 (Trial of Magrolimab (Hu5f9-g4) in Combination With Cetuximab in Participants With Solid Tumors and Advanced Colorectal Cancer).
Investigational
Matched Synonyms: … Immunoglobulin g4(225-proline), anti-(human cd47 antigen) (human-mus musculus monoclonal hu5f9-g4 .gamma ... .4-chain), disulfide with human-mus musculus monoclonal hu5f9-g4 .kappa. …
Matched Description: … NCT02953782 (Trial of Magrolimab (Hu5f9-g4) in Combination With Cetuximab in Participants With Solid Tumors and …
Matched Categories: … Amino Acids, Peptides, and Proteins …
Matched Description: … NCT02953782 (Trial of Magrolimab (Hu5f9-g4) in Combination With Cetuximab in Participants With Solid Tumors and …
Matched Categories: … Amino Acids, Peptides, and Proteins …
Iluzanebart
Investigational
Matched Synonyms: … on myeloid cells 2) (human monoclonal VGL101 γ1-chain), disulfide with human monoclonal VGL101 κ-chain ... Immunoglobulin G1 [296-cysteine,301-glycine,306-cysteine], anti-(human triggering receptor expressed …
Veligrotug
Veligrotug is under investigation in clinical trial NCT00791544 (Dose Finding Study of AVE1642 in Patients With Advanced or Metastatic Liver Carcinoma).
Investigational
Matched Synonyms: … Immunoglobulin G1, anti-(human insulin-like growth factor I receptor) (human-Mus musculus monoclonal ... VRDN-001 γ1-chain), disulfide with human-Mus musculus monoclonal VRDN-001 κ-chain, dimer …
Matched Categories: … Amino Acids, Peptides, and Proteins …
Matched Categories: … Amino Acids, Peptides, and Proteins …
Mecasermin rinfabate
Mecasermin rinfabate is approved for severe primary insulin-like growth factor (IGF) deficiency or in patients with GH gene deletion who have developed antibodies to growth hormone (GH) . Mecasermin rinfabate is similar to DB01277 in that both drugs contain recombinant DNA origin insulin-like growth factor 1 (IGF-1). Mecasermin rinfabate however,...
Approved
Matched Synonyms: … Recombinant human insulin-like growth factor-I/insulin-like growth factor binding protein-3 …
Matched Description: … The binding of IGF-1 to IGFBP-3 is said to extend the half life and reduce the clearance of IGF-1 in ... patients with growth hormone resistant syndromes and low levels of IGFBP-3 though this may represent …
Matched Categories: … Pituitary and Hypothalamic Hormones and Analogues ... Sex Hormones and Insulins ... Somatropin and Somatropin Agonists ... Anterior Pituitary Lobe Hormones and Analogues …
Matched Description: … The binding of IGF-1 to IGFBP-3 is said to extend the half life and reduce the clearance of IGF-1 in ... patients with growth hormone resistant syndromes and low levels of IGFBP-3 though this may represent …
Matched Categories: … Pituitary and Hypothalamic Hormones and Analogues ... Sex Hormones and Insulins ... Somatropin and Somatropin Agonists ... Anterior Pituitary Lobe Hormones and Analogues …
Olenasufligene relduparvovec
Olenasufligene relduparvovec is under investigation in clinical trial NCT03612869 (Study of aavrh10-h.sgsh Gene Therapy in Patients With Mucopolysaccharidosis Type IIIA (MPS IIIA)). It is an adeno-associated virus (AAV) vector that delivers a functional copy of the human SGSH gene.
Investigational
Matched Synonyms: … Dna (recombinant adeno-associated virus 2 vector lys-saf302 human n-sulfoglucosamine sulfohydrolase cdna-specifying …
Matched Description: … It is an adeno-associated virus (AAV) vector that delivers a functional copy of the human SGSH gene. …
Matched Description: … It is an adeno-associated virus (AAV) vector that delivers a functional copy of the human SGSH gene. …
Elranatamab
Elranatamab is a bispecific B-cell maturation antigen (BCMA)-directed CD3 T-cell engager. It is a humanized immunoglobulin 2-alanine kappa antibody derived from two monoclonal antibodies (mAbs), an anti-BCMA mAb and an anti-CD3 mAb, each of which contributes one heavy chain and one light chain to drug structure. The resulting 4-chain bispecific...
Approved
Investigational
Matched Synonyms: … -CHAIN) (HUMAN-MUS MUSCULUS MONOCLONAL PF-06863059 .GAMMA.2-CHAIN), DISULFIDE WITH HUMAN-MUS MUSCULUS ... IMMUNOGLOBULIN G2 (224-ARGININE,265-ALANINE,330-SERINE,331-SERINE), ANTI-(HUMAN CD3 ANTIGEN .EPSILON. ... T-CELL SURFACE GLYCOPROTEIN CD3 EPSILON CHAIN CD3E (T-CELL SURFACE ANTIGEN T3/LEU-4 EPSILON CHAIN)), HUMAN-MUS …
Matched Description: … immunoglobulin 2-alanine kappa antibody derived from two monoclonal antibodies (mAbs), an anti-BCMA mAb and ... an anti-CD3 mAb,[A261060] each of which contributes one heavy chain and one light chain to drug structure …
Matched Categories: … Amino Acids, Peptides, and Proteins …
Matched Description: … immunoglobulin 2-alanine kappa antibody derived from two monoclonal antibodies (mAbs), an anti-BCMA mAb and ... an anti-CD3 mAb,[A261060] each of which contributes one heavy chain and one light chain to drug structure …
Matched Categories: … Amino Acids, Peptides, and Proteins …
Cerliponase alfa
Cerliponase alfa is an enzyme replacement treatment for a specific form of Batten disease. It was the first FDA-approved treatment to slow loss of walking ability (ambulation) in symptomatic pediatric patients 3 years of age and older with late infantile neuronal ceroid lipofuscinosis type 2 (CLN2), also known as tripeptidyl...
Approved
Investigational
Matched Synonyms: … Immature human tripeptidyl-peptidase 1 …
Matched Description: … treatment to slow loss of walking ability (ambulation) in symptomatic pediatric patients 3 years of age and …
Matched Categories: … Enzymes and Coenzymes ... Alimentary Tract and Metabolism ... Amino Acids, Peptides, and Proteins …
Matched Description: … treatment to slow loss of walking ability (ambulation) in symptomatic pediatric patients 3 years of age and …
Matched Categories: … Enzymes and Coenzymes ... Alimentary Tract and Metabolism ... Amino Acids, Peptides, and Proteins …
Spesolimab
Spesolimab is an interleukin-36 (IL-36) receptor antagonist. It is a humanized monoclonal immunoglobulin G1 antibody that was produced in Chinese hamster ovary (CHO) cells by recombinant DNA technology. The biosimilar of the drug, spesolimab-sbzo, was first approved by the FDA in September 2022 to treat generalized pustular psoriasis flares. Spesolimab...
Approved
Investigational
Matched Synonyms: … Immunoglobulin G1, anti-(human interleukin 36 receptor) (humanized monoclonal BI 655130 gamma1-chain) …
Matched Description: … works by inhibiting the inflammatory signaling pathway of IL-36,[L43090] which is often overexpressed and ... Use (CHMP) to be granted marketing authorization in October 2022 and was finally approved in December ... A252220, A252225] Spesolimab received recommendations from the EMA's Committee for Medicinal Products for Human …
Matched Categories: … Amino Acids, Peptides, and Proteins ... Antineoplastic and Immunomodulating Agents …
Matched Description: … works by inhibiting the inflammatory signaling pathway of IL-36,[L43090] which is often overexpressed and ... Use (CHMP) to be granted marketing authorization in October 2022 and was finally approved in December ... A252220, A252225] Spesolimab received recommendations from the EMA's Committee for Medicinal Products for Human …
Matched Categories: … Amino Acids, Peptides, and Proteins ... Antineoplastic and Immunomodulating Agents …
Human papillomavirus type 16 L1 capsid protein residues 2-471 antigen
Approved
Investigational
Matched Name: … Human papillomavirus type 16 L1 capsid protein residues 2-471 antigen …
Human papillomavirus type 18 L1 capsid protein residues 2-472 antigen
Approved
Investigational
Matched Name: … Human papillomavirus type 18 L1 capsid protein residues 2-472 antigen …
Ex vivo expanded autologous human corneal epithelial cells containing stem cells
Holoclar (ex vivo expanded autologous human corneal epithelial cells containing stem cells) is a stem cell therapy used to treat limbal stem cell deficiencies.
Investigational
Matched Name: … Ex vivo expanded autologous human corneal epithelial cells containing stem cells …
Matched Description: … Holoclar (_ex vivo_ expanded autologous human corneal epithelial cells containing stem cells) is a stem …
Matched Description: … Holoclar (_ex vivo_ expanded autologous human corneal epithelial cells containing stem cells) is a stem …
Displaying drugs 1051 - 1075 of 1145 in total