Displaying drugs 10876 - 10900 of 12697 in total
CIGB 2020 Vaccine
CIGB 2020 is a vaccine candidate administered nasally and sublingually, working to strengthen immunity in the areas administered. The vaccine was developed and tested by the Center for Genetic Engineering and Biotechnology (CIGB), in Havana Cuba. As of July, 2020, a Randomized control clinical trial (RPCEC00000306) is underway to evaluate...
Investigational
Matched Description: … potential in suspected contacts of Covid-19 patients. ... As of July, 2020, a Randomized control clinical trial (RPCEC00000306) is underway to evaluate prophylaxis …
Interferon alfa
Natural interferon alpha or Multiferon is obtained from the leukocyte fraction of human blood following induction with Sendai virus. Interferon alfa contains several naturally occurring IFN-α subtypes and is purified by affinity chromatography. Interferon alpha proteins are mainly involved in innate immune response against viral infection. They come in 13...
Investigational
Matched Description: … Of these, IFN-α2 and IFN-α14 are glycosylated. ... Natural interferon alpha or Multiferon is obtained from the leukocyte fraction of human blood following ... Multiferon consists of the 6 major subtypes are IFN-α1, IFN-α2, IFN-α8, IFN-α10, IFN-α14 and IFN-α21. …
HE3286
Investigational
Ibudilast
Ibudilast is an anti-inflammatory and neuroprotective oral agent which shows an excellent safety profile at 60 mg/day and provides significantly prolonged time-to-first relapse and attenuated brain volume shrinkage in patients with relapsing-remitting (RR) and/or secondary progressive (SP) multiple sclerosis (MS). Ibudilast is currently in development in the U.S. (codes: AV-411...
Investigational
NS-398
NS-398 is a COX-2 inhibitor. It was developed as part of the mechanistic study of the cyclooxygenases.
Experimental
Matched Description: … It was developed as part of the mechanistic study of the cyclooxygenases. …
CHF 4227
CHF 4227 is a new selective estrogen receptor modulator (SERM). The compound has a high receptor affinity and has shown promising efficacy in the prevention of bone loss in animal models of osteoporosis. Additionally, the compound has shown no uterotrophic activity suggesting a potential therapeutic advantage over drugs normally used...
Investigational
Matched Description: … loss in animal models of osteoporosis. ... The compound has a high receptor affinity and has shown promising efficacy in the prevention of bone …
Deramciclane
Deramciclane (EGIS-3886) is used for the treatment of a number of anxiety disorders. Deramciclane differs from other anti anxiety medications in that it is not a benzodiazepine and so has a different structure and target. It antagonizes 5-HT2A receptors, agonizes 5-HT2C receptors, and functions as a GABA reuptake inhibitor.
Investigational
Matched Description: … Deramciclane (EGIS-3886) is used for the treatment of a number of anxiety disorders. …
BACTEK-R
MV130 contains different components of whole heat-inactivated gram-positive and -negative bacteria that are involved in upper and lower respiratory infections. These include streptococcus pneumoniae and staphylococcus aureus. Though studies have shown that it reduces the rate of infections in recurrent respiratory tract infections (RRTIs), the complete mechanisms are not fully...
Investigational
Matched Description: … MV130 contains different components of whole heat-inactivated gram-positive and -negative bacteria that ... Though studies have shown that it reduces the rate of infections in recurrent respiratory tract infections …
Grn163l
GRN163L is a novel anti-cancer drug. It has been characterized preclinically and shown to inhibit telomerase in human tumor cells of many cancer types (including lung, breast, prostate, liver, and early stage of human breast cancer), in both cell culture systems and animal models. Study of this drug shows the...
Investigational
Matched Description: … Study of this drug shows the its potential utility in the treatment of patients with hematologic and ... It has been characterized preclinically and shown to inhibit telomerase in human tumor cells of many ... cancer types (including lung, breast, prostate, liver, and early stage of human breast cancer), in both …
Esmirtazapine
Esmirtazapine, known by the standardized identifier SCH 900265, was under development by Organon to treat insomnia and vasomotor symptoms associated with menopause. Esmirtazapine is the (S)-(+)-enantiomer of mirtazapine and possesses similar overall pharmacology. This includes inverse agonist activity of H1 and 5-HT2 receptors and antagonism of α2-adrenergic receptors. Merck has...
Investigational
Matched Description: … This includes inverse agonist activity of H1 and 5-HT2 receptors and antagonism of α2-adrenergic receptors ... Esmirtazapine is the (S)-(+)-enantiomer of mirtazapine and possesses similar overall pharmacology. ... Merck has terminated its internal clinical development program for esmirtazapine as of March 2010. …
Zanidatamab
According to Zymeworks, "ZW25 is a bispecific antibody that can simultaneously bind two non-overlapping epitopes, known as biparatopic binding, of HER2 resulting in dual HER2 signal blockade, increased binding and removal of HER2 protein from the cell surface, and potent effector function. These combined mechanisms of action have led to...
Investigational
Matched Description: … of breast and gastric cancers." ... HER2 resulting in dual HER2 signal blockade, increased binding and removal of HER2 protein from the ... These combined mechanisms of action have led to significant anti-tumor activity in preclinical models …
VA-MENGOC-BC®
VA-MENGOC-BC is a meningococcal B and C vaccine and an outer membrane vesicle (OMV)-based vaccine. The OMVs contain over 100 proteins, and are derived from meningococcal group B and capsular polysaccharide of meningococcal group C. As there already exists a polysaccharide-based vaccine against meningococcal disease originating from serogroups A,C,W135, and...
Investigational
Matched Description: … This vaccine causes induction of bactericidal antibodies with broad cross-reactivity. ... OMVs contain over 100 proteins, and are derived from meningococcal group B and capsular polysaccharide of ... As of August 2020, this vaccine is being tested for prophylaxis against COVID-19 in human clinical trials …
Robenidine
Robenidine is identified as a coccidiostat drug, which slows both the growth and reproductive cycles of coccidian parasites. Robenidine is used to control coccidiosis, a lethal infection in poultry which has shown a significant economic burden. Despite the availability of other agents to treat coccidiosis, robenidine has been proven to...
Experimental
Vet approved
Matched Description: … by slowing the development of antimicrobial resistance. ... Robenidine is identified as a coccidiostat drug, which slows both the growth and reproductive cycles of ... in delaying the development of antibiotic resistance through intermittent and rotating use with other …
MIV-701
MIV-701 is a selective, potent inhibitor of the protease Cathepsin K. It is developed for the treatment of osteoporosis.
Investigational
Matched Description: … It is developed for the treatment of osteoporosis. ... MIV-701 is a selective, potent inhibitor of the protease Cathepsin K. …
Filociclovir
Filociclovir is under investigation in clinical trial NCT01433835 (Safety and Pharmacokinetics of Single Oral Doses of Filociclovir in Healthy Volunteers).
Investigational
Matched Description: … Oral Doses of Filociclovir in Healthy Volunteers). ... Filociclovir is under investigation in clinical trial NCT01433835 (Safety and Pharmacokinetics of Single …
Nevanimibe
Nevanimibe is under investigation in clinical trial NCT03053271 (A Study of ATR-101 for the Treatment of Endogenous Cushing's Syndrome).
Investigational
Matched Description: … of Endogenous Cushing's Syndrome). ... Nevanimibe is under investigation in clinical trial NCT03053271 (A Study of ATR-101 for the Treatment …
DSP107
DSP107 is a bi-functional, trimeric, fusion protein composed of sequences from the extracellular domain of SIRPα and 4-1BBL.
Investigational
Matched Description: … of SIRPα and 4-1BBL. ... DSP107 is a bi-functional, trimeric, fusion protein composed of sequences from the extracellular domain …
MDX-1379
MDX-1379 vaccine consists of two gp100 melanoma peptides. This drug is underinvestigation to treat malignant melanoma.
Investigational
Matched Description: … MDX-1379 vaccine consists of two gp100 melanoma peptides. …
13-deoxydoxorubicin
GPX-100 is an anthracycline anticancer drug that belongs to the family of drugs called antitumor antibiotics.
Investigational
Matched Description: … GPX-100 is an anthracycline anticancer drug that belongs to the family of drugs called antitumor antibiotics …
REN-850
REN-850 is an oral drug for multiple sclerosis which is in Phase I of clinical trials.
Investigational
Matched Description: … REN-850 is an oral drug for multiple sclerosis which is in Phase I of clinical trials. …
Levodropropizine
Levodropropizine is under investigation in clinical trial NCT01573663 (A Drug-Drug Interaction Study of Ambroxol and Levodropropizine).
Investigational
Matched Description: … Levodropropizine is under investigation in clinical trial NCT01573663 (A Drug-Drug Interaction Study of …
Cevipabulin
Cevipabulin has been used in trials studying the treatment and educational/counseling/training of Tumors and Neoplasms.
Investigational
Matched Description: … Cevipabulin has been used in trials studying the treatment and educational/counseling/training of Tumors …
Blosozumab
Blosozumab has been used in trials studying the basic science and treatment of Osteoporosis and Osteoporosis, Postmenopausal.
Investigational
Matched Description: … Blosozumab has been used in trials studying the basic science and treatment of Osteoporosis and Osteoporosis …
Apocynin
Acetovanillone has been used in trials studying the treatment of Bronchial Asthma and Chronic Obstructive Pulmonary Disease.
Investigational
Matched Description: … Acetovanillone has been used in trials studying the treatment of Bronchial Asthma and Chronic Obstructive …
Suptavumab
Suptavumab has been used in trials studying the treatment and basic science of Respiratory Syncytial Virus Infections.
Investigational
Matched Description: … Suptavumab has been used in trials studying the treatment and basic science of Respiratory Syncytial …
Displaying drugs 10876 - 10900 of 12697 in total