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Displaying drugs 11051 - 11075 of 12071 in total
DG051 is a novel small-molecule inhibitor of leukotriene A4 hydrolase (LTA4H), the protein made by one of the genes in the leukotriene pathway that has been shown to link to risk of heart attack. DG051 is designed to decrease risk of heart attack by decreasing the production of leukotriene B4...
Investigational
Matched Description: … DG051 is a novel small-molecule inhibitor of leukotriene A4 hydrolase (LTA4H), the protein made by one ... by decreasing the production of leukotriene B4 (LTB4), an end product of the leukotriene pathway and a
Guvacine is a pyridine alkaloid found in the Areca nut (also known as the Betel nut). It is an experimental drug with no approved indication. Experimental studies are still being investigated to determine all of the physiological effects and mechanisms of action of guvacine. Currently it has been determined that...
Experimental
Matched Description: … Guvacine is a pyridine alkaloid found in the Areca nut (also known as the Betel nut). ... Currently it has been determined that guvacine is a specific GABA reuptake inhibitor with no significant …
BacTRL-Spike is composed of a bacterial medium with colony-forming-units of live Bifidobacterium longum engineered to deliver synthetic DNA encoding spike protein from SARS-CoV-2 contained by plasmids. The vaccine was developed by Symvivo Corporation. As of June, 2020, the company is pursuing a Phase 1, Randomized, Observer-Blind, Placebo-Controlled Trial (NCT04334980) to...
Investigational
Matched Description: … BacTRL-Spike is composed of a bacterial medium with colony-forming-units of live Bifidobacterium longum ... As of June, 2020, the company is pursuing a Phase 1, Randomized, Observer-Blind, Placebo-Controlled …
VGV-1 is a potential salvage therapy for treatment of HIV infected people who have failed anti-retroviral therapy.
Investigational
Matched Description: … VGV-1 is a potential salvage therapy for treatment of HIV infected people who have failed anti-retroviral …
Niguldipine is a calcium channel blocker drug (CCB) with a1-adrenergic antagonist properties.
Experimental
Matched Description: … Niguldipine is a calcium channel blocker drug (CCB) with a1-adrenergic antagonist properties. …
Gestonorone is often mistaken for gestonorone capproate which has a different chemical structure.
Experimental
Matched Description: … Gestonorone is often mistaken for gestonorone capproate which has a different chemical structure. …
TNG908 is a small molecule inhibitor of protein arginine methyl transferase 5 (PRMT5).
Investigational
Matched Description: … TNG908 is a small molecule inhibitor of protein arginine methyl transferase 5 (PRMT5). …
TTAX01 is a cryopreserved human umbilical cord product being developed by TissueTech.
Investigational
Matched Description: … TTAX01 is a cryopreserved human umbilical cord product being developed by TissueTech.[L47246] …
INBRX-101 is a recombinant human alpha-1 antitrypsin (AAT)-Fc fusion protein.
Investigational
Matched Description: … INBRX-101 is a recombinant human alpha-1 antitrypsin (AAT)-Fc fusion protein. …
VTP-201227 has a novel mechanism of action and is being developed as a topical agent for the treatment of psoriasis with potential extensions into other dermatological indications. It is being developed by Vitae Pharmaceuticals.
Investigational
Matched Description: … VTP-201227 has a novel mechanism of action and is being developed as a topical agent for the treatment …
Pexelizumab is a humanized monoclonal antibody used as an immunosuppressive drug. It is being investigated by Alexion Pharmaceuticals.
Investigational
Matched Description: … Pexelizumab is a humanized monoclonal antibody used as an immunosuppressive drug. …
PPI-2458 represents a potentially new and important addition to the growing list of therapeutics aimed at specific molecular oncology targets. PPI-2458 is a novel, proprietary molecule belonging to the fumagillin class of compounds that specifically targets the MetAP-2 enzyme. This class of compounds has been shown to prevent both abnormal...
Investigational
Matched Description: … PPI-2458 represents a potentially new and important addition to the growing list of therapeutics aimed ... PPI-2458 is a novel, proprietary molecule belonging to the fumagillin class of compounds that specifically …
Tertatolol is a beta blocker.
Experimental
Matched Description: … Tertatolol is a beta blocker. …
IDD-3 is a therapeutic specific immunostimulant developed by IDM Pharma in partnership with sanofi-aventis. It consists of mature dendritic cells loaded with lysates from melanoma tumor cell lines. It includes Dendritophages that are dendritic cells, a type of specialized immune cells derived from the patient's own white blood cells.
Investigational
Matched Description: … IDD-3 is a therapeutic specific immunostimulant developed by IDM Pharma in partnership with sanofi-aventis ... It includes Dendritophages that are dendritic cells, a type of specialized immune cells derived from …
Thienylfentanyl is a fentanyl analog analgesic that was sold on the black market in the 1980s until the Federal Analog Act scheduled drugs based on structural similarity rather than scheduling drugs individually. Thienylfentanyl has a similar synthesis pathway to fentanyl except 2-(2-bromoethyl)thiophene is substituted for phenethyl bromide.
Illicit
Matched Description: … Thienylfentanyl is a fentanyl analog analgesic that was sold on the black market in the 1980s until the ... Thienylfentanyl has a similar synthesis pathway to fentanyl except 2-(2-bromoethyl)thiophene is substituted …
OTL-201 is an investigational hematopoietic stem cell (HSC) gene therapy being developed by Orchard Therapeutics for the treatment of mucopolysaccharidosis type IIIA (MPS-IIIA). It consists of a lentiviral vector to insert a functional copy of the human N-Sulfoglucosamine Sulfohydrolase (SGSH) gene into autologous CD34+ hematopoietic stem cells.
Investigational
Matched Description: … It consists of a lentiviral vector to insert a functional copy of the human N-Sulfoglucosamine Sulfohydrolase …
DG041 is a novel, first-in-class, orally-administered small molecule developmented for the prevention of arterial thrombosis and its complications. DG041, an anti-platelet compound, has shown to be a selective and potent antagonist of the EP3 receptor for prostaglandins E2. EP3 is a target that associates with increased risk of various vascular...
Investigational
Matched Description: … EP3 is a target that associates with increased risk of various vascular diseases. ... DG041 is a novel, first-in-class, orally-administered small molecule developmented for the prevention ... DG041, an anti-platelet compound, has shown to be a selective and potent antagonist of the EP3 receptor …
Sirna-027 is a chemically modified short interfering RNA(siRNA) targeting Vascular Endothelial Growth Factor Receptor-1(VEGFR-1). VEGFR-1 is a key component of the clinically validated vascular endothelial growth factor (VEGF) pathway. Sirna-027 is developed by Sirna Therapeutics and is under the phase I of clinical trails. It is used to treat Macular...
Investigational
Matched Description: … Sirna-027 is a chemically modified short interfering RNA(siRNA) targeting Vascular Endothelial Growth ... VEGFR-1 is a key component of the clinically validated vascular endothelial growth factor (VEGF) pathway …
GlycoPEG-GCSF is a long-acting GlycoPEGylated granulocyte colony stimulating factor for the treatment of chemotherapy-induced neutropenia.
Investigational
Matched Description: … GlycoPEG-GCSF is a long-acting GlycoPEGylated granulocyte colony stimulating factor for the treatment …
A pteridine derivative present in body fluids; elevated levels result from immune system activation, malignant disease, allograft rejection, and viral infections. (From Stedman, 26th ed) Neopterin also serves as a precursor in the biosynthesis of biopterin.
Experimental
Matched Description: … A pteridine derivative present in body fluids; elevated levels result from immune system activation, ... (From Stedman, 26th ed) Neopterin also serves as a precursor in the biosynthesis of biopterin. …
SIG-001 is a cultured human retinal pigment epithelial cell line (ARPE-19) genetically modified with a non-viral vector to express B domain deleted human factor VIII protein, encapsulated within two-layer modified alginate spheres.
Investigational
Matched Description: … SIG-001 is a cultured human retinal pigment epithelial cell line (ARPE-19) genetically modified with ... a non-viral vector to express B domain deleted human factor VIII protein, encapsulated within two-layer …
BL-1020 is a first in class novel compound for the treatment of schizophrenia. It is being developed by BioLineRx (BioLine).
Investigational
Matched Description: … BL-1020 is a first in class novel compound for the treatment of schizophrenia. …
HCV-086 is a small molecule antiviral designed to block an enzyme required for the replication of the hepatitis C virus.
Investigational
Matched Description: … HCV-086 is a small molecule antiviral designed to block an enzyme required for the replication of the …
Senicapoc (ICA-17043) is a novel Gardos channel blocker. It is being investigated for the treatment of sickle cell disease.
Investigational
Matched Description: … Senicapoc (ICA-17043) is a novel Gardos channel blocker. …
Displaying drugs 11051 - 11075 of 12071 in total