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Displaying drugs 11251 - 11275 of 12702 in total
Peptide YY (3-36)
Peptide YY (3-36), a synthetic human PYY 3-36, is a compound being evaluated for the treatment of obesity. It reduces appetite and increases satiety in obese patients.
Investigational
Matched Description: … It reduces appetite and increases satiety in obese patients. …
ATL1101
ATL1101 is a second-generation antisense drug designed to block the synthesis of the IGF-1 receptor, a protein involved in the regulation of cell overgrowth in psoriasis. ATL1101 is being developed as a cream for the topical treatment of mild to moderate cases of psoriasis.
Investigational
Matched Description: … the regulation of cell overgrowth in psoriasis. ... second-generation antisense drug designed to block the synthesis of the IGF-1 receptor, a protein involved in …
V1003
V1003 is an intranasal formulation of buprenorphine, an opiate analgesic, for the management of post-operative pain in hospital and home settings. Buprenorphine is a well-known analgesic and the intranasal formulation has the potential to provide a convenient alternative to other treatments, allowing patients to manage their post-operative pain both prior...
Investigational
Matched Description: … intranasal formulation of buprenorphine, an opiate analgesic, for the management of post-operative pain in …
ARX201
ARX201 (PEG-ahGH) is a recombinant form of human growth hormone that has been modified using Ambrx’s patented ReCODE™ technology to achieve precise spatial positioning of the site of polyethylene glycol (PEG) attachment to human growth hormone, by biosynthetic incorporation of a chemically unique amino acid (ahGH). ARX201 has improved pharmacological...
Investigational
TM30339
TM30339 is an analogue of the natural hormone Pancreatic Polypeptide (PP), which is released in connection with meals. TM30339 works through the same receptor as the natural satiety hormone, Pancreatic Polypeptide (PP), but TM30339 has improved properties compared with PP. TM30339 thus imitates a natural mechanism, a satiety signal from...
Investigational
Matched Description: … the regulation of food intake in humans. ... TM30339 is an analogue of the natural hormone Pancreatic Polypeptide (PP), which is released in connection ... TM30339 thus imitates a natural mechanism, a satiety signal from the gastrointestinal system involved in …
AX200
AX200, which has been developed for the treatment of stroke, is the most advanced drug candidate and is halfway through the process of gaining clinical approval. The expression of the endogenous AX200 protein in the brain is increased after brain damage. Thus, if this drug administered in the acute phase...
Investigational
Matched Description: … The expression of the endogenous AX200 protein in the brain is increased after brain damage. ... this is where the double neurotherapeutic approach is most beneficial: AX200 stops neuronal cell death in ... Thus, if this drug administered in the acute phase of stroke, the brain’s own protective action is supported …
ND7001
ND7001, a selective PDE2 inhibitor is in clinical trials for the treatment of depression. ND7001 is a solid. Known drug targets of ND7001 including phosphodiesterase 2A, cGMP-stimulated and cGMP-dependent 3',5'-cyclic phosphodiesterase. It is a new type of antidepressant drug with anxiolytic activity. It is the first representative of a new...
Investigational
Matched Description: … ND7001, a selective PDE2 inhibitor is in clinical trials for the treatment of depression. …
SSR-126517E
SSR-126517E is a second generation synthetic pentasaccharide that binds antithrombin with such high affinity that it assumes a plasma half-life of 80 hours.
Investigational
RI 624
RI 624 is a novel humanized monoclonal antibody that blocks nerve growth factor (NGF), a key mediator of acute and chronic pain. RI 624 is being developed by Rinat and is currently in Phase I clinical trials.
Investigational
Matched Description: … RI 624 is being developed by Rinat and is currently in Phase I clinical trials. …
Mitumomab
Mitumomab, an anti-BEC-2 monoclonal antibody derived from mice, was previously studied to treat small cell lung carcinoma in combination with BCG vaccination.
Investigational
Matched Description: … -2 monoclonal antibody derived from mice, was previously studied to treat small cell lung carcinoma in …
Sufugolix
Investigational
Omiganan
Omiganan has been investigated for the treatment of Mupirocin-resistant MRSA skin infections.
Investigational
Priralfinamide
Investigational
Tetrahydropalmatine
Tetrahydropalmatine is under investigation in clinical trial NCT02118610 (Treatment of Schizophrenia With L-tetrahydropalmatine (l-THP): a Novel Dopamine Antagonist With Anti-inflammatory and Antiprotozoal Activity).
Investigational
Matched Description: … Tetrahydropalmatine is under investigation in clinical trial NCT02118610 (Treatment of Schizophrenia …
Matched Categories: … Heterocyclic Compounds, Fused-Ring …
Matched Categories: … Heterocyclic Compounds, Fused-Ring …
Tosedostat
Tosedostat has been used in trials studying the treatment and supportive care of AML, Leukemia, Pancreas Cancer, Multiple Myeloma, and Pancreatic Cancer, among others.
Tosedostat is an inhibitor of the M1 family of aminopeptidases, in particular PuSA, and LTA4 hydrolase. It has demonstrated anti-tumour activity in a number of models...
Investigational
Matched Description: … in synergy with cytotoxic agents such as carboplatin and paclitaxel. ... It entered the clinical trial in patients with haematological malignancies. ... Tosedostat has been used in trials studying the treatment and supportive care of AML, Leukemia, Pancreas …
Refanezumab
Refanezumab is under investigation in clinical trial NCT00833989 (Safety Escalating Repeat IV, in Stroke Patients).
Investigational
Matched Description: … Refanezumab is under investigation in clinical trial NCT00833989 (Safety Escalating Repeat IV, in Stroke …
Troriluzole
Troriluzole is under investigation in clinical trial NCT03701399 (Troriluzole in Adult Subjects With Spinocerebellar Ataxia).
Investigational
Matched Description: … Troriluzole is under investigation in clinical trial NCT03701399 (Troriluzole in Adult Subjects With …
IMG-7289
IMG-7289 is under investigation in clinical trial NCT03136185 (IMG-7289 in Patients With Myelofibrosis).
Investigational
Matched Description: … IMG-7289 is under investigation in clinical trial NCT03136185 (IMG-7289 in Patients With Myelofibrosis …
Budigalimab
Budigalimab is under investigation in clinical trial NCT04807972 (Study to Evaluate Adverse Events and Change in Disease Activity When Intravenous (IV) Infusion of ABBV-927 Is Administered in Combination With IV Modified FOLFIRINOX (Mffx) With or Without IV Budigalimab Compared to Mffx in Adult Participants With Untreated Pancreatic Cancer Metastasis).
Investigational
Matched Description: … Change in Disease Activity When Intravenous (IV) Infusion of ABBV-927 Is Administered in Combination ... Budigalimab is under investigation in clinical trial NCT04807972 (Study to Evaluate Adverse Events and ... With IV Modified FOLFIRINOX (Mffx) With or Without IV Budigalimab Compared to Mffx in Adult Participants …
Eritoran
Eritoran is a structural analogue of the lipid A portion of lipopolysaccharide (LPS). It is being developed by Eisai Research Institute of Boston for the treatment of severe sepsis.
Investigational
Bectumomab
Bectumomab (marketed under the trade name LymphoScan®) is a mouse monoclonal antibody and which it's used to treat non-Hodgkin's lymphoma. It has a radioisotope, technetium (99m TC) which it's added.
Investigational
EHT899
EHT899 is a proprietary formulation of an HBV viral protein designed to eliminate the undesirable immune response elicited by the HBV infection. It also apparently enhances a secondary immune response to clear the viral infection, resulting in reduction in liver damage and decrease in viral load.
Investigational
Matched Description: … in liver damage and decrease in viral load. ... It also apparently enhances a secondary immune response to clear the viral infection, resulting in reduction …
Elsamitrucin
The cytostatic agent Elsamitrucin is a new fermentation product active in a variety of in vivo tumor models of murine and human origin. (PMID: 8150873)
Investigational
Matched Description: … The cytostatic agent Elsamitrucin is a new fermentation product active in a variety of in vivo tumor …
MP4
MP4 is a hemoglobin-based oxygen carrier designed to serve as an alternative for blood transfusions. It is free of harmful vasoactivity and provides targeted oxygen delivery to tissues at risk of oxygen deprivation.
Investigational
Displaying drugs 11251 - 11275 of 12702 in total