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Displaying drugs 11476 - 11500 of 11850 in total
4-Phenylfentanyl
4-Phenylfentanyl is a sythetic opioid derived from fentanyl. 4-Phenylfentanyl is around 8x the potency of fentanyl in analgesic tests on animals, but more complex 4-heteroaryl derivatives such as substituted thiophenes and thiazoles are more potent still, as they are closer bioisosteres to the 4-carbomethoxy group of carfentanil.
Illicit
Matched Description: … Phenylfentanyl is a sythetic opioid derived from fentanyl. 4-Phenylfentanyl is around 8x the potency of fentanyl in …
Thienylfentanyl
Thienylfentanyl is a fentanyl analog analgesic that was sold on the black market in the 1980s until the Federal Analog Act scheduled drugs based on structural similarity rather than scheduling drugs individually. Thienylfentanyl has a similar synthesis pathway to fentanyl except 2-(2-bromoethyl)thiophene is substituted for phenethyl bromide.
Illicit
Matched Description: … Thienylfentanyl is a fentanyl analog analgesic that was sold on the black market in the 1980s until the …
Zolazepam
Zolazepam is a pyrazolodiazepinone derivative used as an anaesthetic in veterinary medicine. Zolazepam is typically used in combination with the NMDA antagonist tiletamine or the α2 adrenoceptor agonist xylazine. It is around four times the potency of diazepam but it is both water-soluble and un-ionized at physiological pH meaning that...
Vet approved
Matched Description: … Zolazepam is a pyrazolodiazepinone derivative used as an anaesthetic in veterinary medicine. ... Zolazepam is typically used in combination with the NMDA antagonist tiletamine or the α2 adrenoceptor …
Alaproclate
Alaproclate was developed as one of the first selective serotonin reuptake inhibitor (SSRI) antidepressants by Astra AB (now AstraZeneca) in the 1970s. Development was discontinued due to concerns over hepatotoxicity observed in animal studies. Alaproclate has also been found to act as a non-competitive NMDA receptor antagonist although without discriminative...
Experimental
Matched Description: … Development was discontinued due to concerns over hepatotoxicity observed in animal studies. ... the first selective serotonin reuptake inhibitor (SSRI) antidepressants by Astra AB (now AstraZeneca) in …
J147
J147 is an experimental drug with reported effects against both Alzheimer's disease and ageing in mouse models of accelerated aging. [A31606,A31607,A31608] It is a curcumin derivative and a potent neurogenic and neuroprotective drug candidate initially developed for the treatment of neurodegenerative conditions associated with aging that impacts many pathways implicated...
Experimental
Matched Description: … J147 is an experimental drug with reported effects against both Alzheimer's disease and ageing in mouse ... treatment of neurodegenerative conditions associated with aging that impacts many pathways implicated in …
Bimagrumab
Bimagrumab has been used in trials studying the treatment and supportive care of Sarcopenia, Skeletal Muscle, Mechanical Ventilation, Sporadic Inclusion Body Myositis, and Sporadic Inclusion Body Myositis (sIBM), among others.
Investigational
Matched Description: … Bimagrumab has been used in trials studying the treatment and supportive care of Sarcopenia, Skeletal …
Nerve Growth Factor
Nerve Growth Factor has been used in trials studying the prevention and treatment of Mental Handicap, Alzheimer's Disease, Traumatic Brain Injury, Cerebral Palsy Children, and Delayed Speech Development, among others.
Investigational
Matched Description: … Nerve Growth Factor has been used in trials studying the prevention and treatment of Mental Handicap, …
Emrusolmin
Emrusolmin restores hippocampal synaptic and transcriptional plasticity as well as spatial memory in a mouse model for Alzheimer's disease, when given orally before or after the onset of pathology.
Experimental
Matched Description: … Emrusolmin restores hippocampal synaptic and transcriptional plasticity as well as spatial memory in …
Brimapitide
Brimapitide is under investigation in clinical trial NCT01570205 (Safety, Tolerability and PK of a Single iv Infusion of 10, 40, and 80 µg/kg XG-102 Administered to Healthy Volunteers).
Investigational
Matched Description: … Brimapitide is under investigation in clinical trial NCT01570205 (Safety, Tolerability and PK of a Single …
RAPA-501-Allo
RAPA-501-ALLO is composed of T-cells extracted from healthy volunteers; these cells are then reprogrammed ex vivo in a process that involves de-differentiation and re-differentiation.
Investigational
Matched Description: … composed of T-cells extracted from healthy volunteers; these cells are then reprogrammed _ex vivo_ in …
KITE-585
KITE-585 is an autologous, fully-human anti-B cell maturation antigen (BCMA) chimeric antigen receptor (CAR) T cell therapy. It is being investigated in the treatment of multiple myeloma.
Investigational
Matched Description: … It is being investigated in the treatment of multiple myeloma. …
Iproniazid
Withdrawn from the Canadian market in July 1964 due to interactions with food products containing tyrosine.
Withdrawn
Matched Description: … Withdrawn from the Canadian market in July 1964 due to interactions with food products containing tyrosine …
Tofimilast
Tofimilast has been used in trials studying the treatment of Asthma and Pulmonary Disease, Chronic Obstructive.
Investigational
Matched Description: … Tofimilast has been used in trials studying the treatment of Asthma and Pulmonary Disease, Chronic Obstructive …
Tofogliflozin
Tofogliflozin has been used in trials studying the treatment and prevention of Diabetes Mellitus Type 2.
Investigational
Matched Description: … Tofogliflozin has been used in trials studying the treatment and prevention of Diabetes Mellitus Type …
Icariin
Icariin has been investigated for the basic science of the Pharmacokinetic Profile of Icariin in Humans.
Investigational
Matched Description: … Icariin has been investigated for the basic science of the Pharmacokinetic Profile of Icariin in Humans …
ORM-12741
ORM-12741 has been used in trials studying the basic science and treatment of Alzheimer's Disease.
Investigational
Matched Description: … ORM-12741 has been used in trials studying the basic science and treatment of Alzheimer's Disease. …
Evodenoson
Evodenoson has been used in trials studying the treatment of Open-angle Glaucoma and Ocular Hypertension.
Investigational
Matched Description: … Evodenoson has been used in trials studying the treatment of Open-angle Glaucoma and Ocular Hypertension …
Perzinfotel
Perzinfotel has been used in trials studying the treatment of Diabetes Mellitus and Diabetic Neuropathy, Painful.
Investigational
Matched Description: … Perzinfotel has been used in trials studying the treatment of Diabetes Mellitus and Diabetic Neuropathy …
Sonedenoson
Sonedenoson has been used in trials studying the treatment of Foot Ulcer, Diabetic and Diabetes Complications.
Investigational
Matched Description: … Sonedenoson has been used in trials studying the treatment of Foot Ulcer, Diabetic and Diabetes Complications …
BI-671800
Bi 671800 has been used in trials studying the treatment of Asthma and Rhinitis, Allergic, Perennial.
Investigational
Matched Description: … Bi 671800 has been used in trials studying the treatment of Asthma and Rhinitis, Allergic, Perennial. …
Anhydrovinblastine
Anhydrovinblastine has been used in trials studying the treatment of Unspecified Adult Solid Tumor, Protocol Specific.
Investigational
Matched Description: … Anhydrovinblastine has been used in trials studying the treatment of Unspecified Adult Solid Tumor, Protocol …
Mosedipimod
Mosedipimod has been used in trials studying the supportive care and treatment of Chemotherapy-induced Neutropenia.
Investigational
Matched Description: … Mosedipimod has been used in trials studying the supportive care and treatment of Chemotherapy-induced …
Taprenepag
Taprenepag has been used in trials studying the treatment of Ocular Hypertension and Glaucoma, Open-Angle.
Investigational
Matched Description: … Taprenepag has been used in trials studying the treatment of Ocular Hypertension and Glaucoma, Open-Angle …
GSK-376501
GSK376501 has been used in trials studying the treatment and diagnostic of Type 2 Diabetes Mellitus.
Investigational
Matched Description: … GSK376501 has been used in trials studying the treatment and diagnostic of Type 2 Diabetes Mellitus. …
Nerispirdine
Nerispirdine has been used in trials studying the treatment of Neuritis, Optic Nerve, and Multiple Sclerosis.
Investigational
Matched Description: … Nerispirdine has been used in trials studying the treatment of Neuritis, Optic Nerve, and Multiple Sclerosis …
Displaying drugs 11476 - 11500 of 11850 in total